Recent content by attheedgeofscience

Back in 2013 when my tinnitus journey began, you could not visit any tinnitus community without hearing about AM-101. At some point I started digging into the science behind the drug and its mechanism-of-action on the NMDA receptors i.e. the ones that respond to glutamate (the primary...

The rule of thumb I apply is to wear earplugs whenever I leave the house. It's only a matter of time before someone honks their car horn while you are in their vicinity or someone slams a door in your face. Going around unplugged is an accident waiting to happen... A worthwhile read (with a...

Seems like you have done a lot. The only things I can add to the list is to be consistent with ear protection and to have a read of the pubmed-literature regarding NAC, Pycnogenol, Taurine, Magnesium, Zinc, and Creatine. As for earplugs, there has never been a downside to using these, but there...

Seems like someone has thrown a curse at the inner ear pharma field. First Auris Medical, then Otonomy, and now Frequency Therapeutics. That's +10 years of developments wiped away just like that. Hard to believe...

Well, the efficacy of OTO-313 was evaluated using the TFI score (which is fully subjective). OTO-413 is evaluated using speech-in-noise testing (which is objective). But the result can of course be influenced in one direction (but not the other ) i.e. pretending not to hear something which...

Perhaps give Taurine, NAC, Creatine, Magnesium and Pycnogenol a go. Protect your ears whenever outside in an environment you can't control. You never know when a driver is going to honk the horn or when someone is going to slam a door in your face... Over time, your tinnitus may improve (by...

Pretty incredible that a full decade of clinical trials still hasn't yielded any tangible progress. That's pretty much all I have to say. Best wishes to everyone.

No, no impact on tinnitus in my case. Got the Pfizer shot (x 2) five weeks apart. However, this article looks into a three-patient case study where a COVID-19 vaccine is deemed responsible for the subsequent resulting tinnitus.

This thread was created more than five years ago (by yours truly) with no developments since then (as far as I know). However, earlier this year, an in vivo-study was released on RL-81 suggesting that the channel activator is effective at the preclinical stage. It would seem, therefore, that the...

Hmmmm... wrong... both the FDA and the EMA say that a 10 dB improvement is clinically significant: "With regard to Sonsuvi , the FDA and EMA have indicated that a 10 dB improvement in hearing thresholds is clinically significant, in line with clinical practice. However, no product has been...

It doesn't matter that those deficits are present – they will be omnipresent and will show up in both the before and after scenario thereby allowing you to "subtract" two population averages from each other. The way you phrase it seems to suggest that a certain deficit will only show up in one...

The reason that the interim analysis showed the study failed (even though WR scores improved) is that when WR scores (also) improved in the placebo group (which serves as a reference point), it makes it that much harder for the drug arm of the trial (i.e. those getting FX-322) to demonstrate an...

The example you provide compares two different pieces of equipment (it is quite obvious from the readout that the testing was done in different places). This is a separate case. Even if there is a margin of error of ±10 dB, testing done using the same equipment will still have the capability...

I agree: any person in their right mind wouldn't go through all the trouble it takes to set up a biotech just to be a fraud. Fraud in business falls into two main categories: Those intending to be a fraud from the outset (example: Ponzi Scheme, Bernard Madoff). Those who run an honest company...

I wouldn't worry about it, but also not likely to help. For supplements, try Creatine, Pycnogenol, Turmeric, and Magnesium. Perhaps also NAC, Zinc, and Taurine. Avoid foods loaded with MSG (Monosodium Glutamate) – but not super important (i.e. will probably only spike tinnitus). Protect your...