Recent content by cdog

Hi, could you please tell me where you got the intratympanic steroid injection done? I'm in NYC and I can't seem to find any doctors that would do it...

As to the $$$ side of things, have you looked at the online Canadian pharmacies?

Hmmm, this seems to go against Prof. Tzounopoulus's paper Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus where he says: KCNQ channels, often KCNQ2 and KCNQ3, mediate the native neuronal M-type current. M currents are strongly inhibited by activation...

Can this neural signature be (strongly statistically) correllated with the subjective perception of tinnitus intensity? If so, has there been any study conducted (with a decent sample size) that demonstrated such a correlation? And by correlation I mean both a binary "signature existence...

Well, if he has no symptoms, and will continue to have no symptoms, for some time x in the future, then I think we can all agree that fits the definition of the word "cure". The question is what x should be - is it "the rest of his life", is it "five years (as in five year survival rate)" or is...

My theory is that the key may be to replace the 'normal level target' that homeostatic mechanisms 'go back to'. It could be that the changes which cause tinnitus, such as noise exposure, cause things like calcium (Ca+) concentration levels in the DCN to become really low (because of lack of...

Thank you for finding the paper, @locoyeti ! Just a question on the data bolded above - if the effective therapeutic concentration is 7.4um and at 1200mg/day you only get to 2.0um, it seems that it would require 7.4/2.0 * 1200 = 4320 mg/day of retigabine to get the the therapeutic concentration...

Very interesting...Does anyone have the full text of this article?

I agree too... Time for a flupirtine thread! And willing volunteers..

There are many hypotheses as to the mechanisms that cause and maintain tinnitus. These few pages...

I'm surprised this even needed FDA clearance. I mean, it's just an ipod with an app. Isn't that at odds with both the study it's supposed to be based on and the supposed mechanism of action? The study abstract says "All patients decreased their tinnitus intensity in the first month of...

Right, but if input from the cochlea to, say, the DCN, was truly lost for some specific frequency, then how would you be able to 'fill in' for it using any external sound generating device at that frequency? The cochlea simply would not be capable of transmitting any signal for that frequency...

Nice paper, but I have two comments/questions : 1. Perhaps the decrease in tinnitus intensity was due to better sleep quality, induced by the generated sound (acting as a masker). In other words, perhaps a better study should have had a control group receiving a regular masking sound (e.g...

Purposeful malpractice would cost him much more than just his career...

This portion of the video says the stem cells are attracted to chemokines released near the area of injury : But what are the chemokines released near damaged/defunct inner hair cells? Are they still released years after inner hair cell destruction?