Recent content by EkkoMusic

Sound Pharma announces positive Phase 3 results for the treatment of Meniere's disease with SPI-1005

→ Sound Pharma Announces Phase 3 Study Completion of SPI-1005 for the Treatment of Meniere’s Disease

New study here: Tinnitus following treatment with ultrasonic scaler

Agreed, but from my understanding, that is a direct result of the trauma itself, and it doesn't create chronic/fluctuating hydrops, correct? Very interesting to see -- from my perusal, it looks almost like a 50/50 split of Meniere's patients seeing improvement versus people seeing no...

My response to this is that both tinnitus and hyperacusis are generally a symptom of something else, which explains why they both onset together. Hyperacusis does not cause tinnitus, just as tinnitus does not cause hyperacusis; they are often caused by the same thing, most often hearing loss...

Sounds like the distortion was diplacusis! You’re lucky it eventually resolved, though I’m sorry the hearing loss remained.

Whoa whoa, when was this proven? The Phase 2b trial tested for EHF improvement, yet the announcement this week reported no improvement in secondary outcomes (in which EHF audiogram testing was included). If the drug showed efficacy in any capacity (even in improved EHF hearing thresholds), I...

I mean, sure, but unless there’s something particular about the cochlea we’ve discovered from this, to me it would still make plenty of sense to investigate higher doses. Stronger medicine typically yields a stronger response. Both of Otonomy’s and Frequency Therapeutics’ drugs have been...

Because hearing involves more than communication. Even if EHFs don’t “affect communication”, they are still involved in everyday sounds. Please put an EQ on your favorite song and brickwall out all the information above 8 kHz. While you will still be able to discern the lyrics, how does the rest...

*Easier to treat a symptom.

What if these subjects have hidden hearing loss? For example, I have a dip as narrow as about 940-980 Hz, with a tinnitus tone at 990 Hz.

Can you explain? From what I understand: 1. Certain hair cells are not intrinsically stronger than other hair cells. 2. In cases of SSNHL recovery with steroids, antivirals, etc., high frequency hearing function is less likely to be restored than lower frequency hearing function. Please...

Not to get too off topic but wouldn't an anti-inflammatory also work to reduce excess fluid? If not, why does Prednisone work so well with Meniere's patients?

Hard to say because it’s not like Ménière’s patients don’t also have SSNHL, and tinnitus from that. I’m endlessly unclear if those with Ménière’s experience tinnitus in isolation of other symptom onset (such as SSNHL). If that’s the case, then yes, maybe fluid build-up alone would cause...

Maybe a silly question, but Otonomy hasn't published their peer reviewed journal on the detailed results yet, right? (Similar to this for phase I?) We just know it failed but don't have the data yet to sift through ourselves?