Recent content by spacehunter

You condition the animal to do a certain behaviour when hearing sounds. For example the animal gets electric shocks shortly after a sound is played, or the animals get food at a certain spot while playing a sound. After one induced noise to the animals, they will behave different to the control...

To explain it very quickly: Some papers showed, that NHPN-1010 increases the BDNF concentration (not sure whether studies where animal studies or on vitro). By this, synaptic growth is enhanced and hidden hearing loss hopefully treated (basically in the same way as OTO-413 intends to). As long...

I can totally relate. My tinnitus changed from mild to 24/7 in the last 6 months of my studies. The final worsening happened only days after graduating. I know the feeling when suddenly all the hard work one has done to get to this point becomes suddenly meaningless.

I would still be very cautious as to put too much hope into SPI-1005. What made me wonder in the last weeks is the death of Kent Taylor. SPI-1005 and HPN-07 would have been easily available for a millionaire and surely one tries everything before going into drastic measurements. Obviously if...

This would have made sense if I had used an e-commerce platform or for example PayPal. But this was old school just via email (I found the supplier using chemicalbook.com) and bank wire, so there would have been 0 chance for me getting the money back in any case. Also I have to say that they...

I did not even have to test the sample (I still will for sure, simply because I have access to NMR spectroscopy). Basically the package I got sent contained a cheap foundation ingredient of cosmetics and all the declarations for customs as well as the shipping invoice stating the same. Since...

As a warning to everyone trying to order Ebselen or other chemicals from China: Request first a sample to test for a low price before ordering a larger quantity. I ordered from a Chinese supplier a probe to check and it turned out to be scam. So even if you are provided with legit NMR, HPLC...

As far as I know it has not even started yet. According to this website it will probably be completed in April 2023...

FX-322 was great as it had the promise to cure the problem at (one of) its roots and also because it was being developed rapidly. After the disaster with FX-322, we should lower our expectations. SPI-1005 will at most alleviate our problems, but not cure them. The beauty of SPI-1005, on the...

Jumping on the habituation bandwagon maybe?

The whole situation stills feels so unreal. I also still cannot get over the fact how FREQ acted so positively over the last weeks and the results have been so bad. Do we have a guess since when have they had the data on their desk? It' s just crazy that they released the paper for Phase 1 with...

I still have the feeling we have not consolidated on a clear statement what to make out of the results of the Phase 2. Agreed: it was a disaster compared to our lowest expectations. But what does that mean? Is the whole concept of the drug failed? Is the delivery of the drug failed (even more...

I guess most of us had a hard time believing you since your statements have been very enigmatic and without (solid) proof. May I ask since now all the dust has settled what your sources for your guess have been? Did you kind of had solid proof or was it all just a very sophisticated guess...

I agree with you - besides the two days when I woke up with sudden deafness in my ear, this is the worst day of my life. 2021 did start so well with potential readout for OTO-413, hopefully good news for their drug against Meniere's and the readout for Phase 2a of FX-322. Now Otonomys Meniere's...

Did we already see the extended audiogram changes? I mean it is plausible that more injections do not help with the lower frequencies, but maybe at least more injections benefit the higher frequencies... I think the most important question will be whether they will commence Phase 3 regardless...