Recent content by Tau

Thanks. It is not publicly available, this is my own making, in a laboratory. And yes, it is an intratympanic injection, injected cold, it gels when it reaches body temperature, hence the slow release. Modified FX-322 was not a miracle, maybe slight benefit to one ultra high frequency, also...

Nothing new. I'll be doing some other stuff, I have already done progenitor cell activation (adapted Frequency Therapeutics intratympanic formulation, slow release BDNF coming soon).

I had an ENT suction out lidocaine before an IT shot. It was not that loud, personally.

Yep, tastes even worse than HPN-07.

They saw audiogram improvements in their animal models.

The exosomes that I receive are derived from umbilical cord mesenchymal stem cells. I can get the cells themselves, too, but cell therapy is riskier (and the cells will likely not cross the round window if injected intratympanically). I'll reiterate the same thing I have posted before...

Could you please provide any publications on intratympanic exosomes then? I'm talking human trials, I do know they seem to be effective in animals. However, hearing-wise, they did nothing to me (systemically at very high doses). I will try growth factors (BDNF and/or NT-3) intratympanically...

Progenitor Cell Activation, what Frequency Therapeutics were doing.

I personally know two people who have had stem cell exosomes administered intratympanically (1 week of IT shots, a shot every other day, so either 3 or 4 shots, I forget). No improvement. One shot was around 0.5 ml, containing 50-100 billion exosomes. All that aside, the PCA approach worked...

Literally their patents.

For those interested, Spiral Therapeutics has patents on their slow release gel. It's a chemically crosslinked polymer - you mix PEG esters with trilysine amines and can control the crosslinking reaction by adjusting the pH. This gel is more durable than a P407 gel (Otonomy and Frequency...

Yes, and from this and their modelling they 100% knew that it would not really be effective below 9-10 kHz.

To be honest, FX-322 did reach 10 kHz at required concentrations of CHIR99021 and sodium valproate to work. Now testing speech was an interesting choice, but it makes sense because understanding speech is one the main goals of hearing restoration. Getting deeper required *some* changes to the...

Headphones, I could not hear the sound for some reason. Increased the volume, still could not hear it. But it did damage.

It was not. The regular FX-322 is 88 mg/ml sodium valproate (HDACi), 3.1 mg/ml CHIR99021 (GSK3i), 5% w/v DMSO (solvent for CHIR) and 16.1% w/v Pluronic P407 (gelling agent). FX-345 is likely (based on very limited info they released) the same 88 mg/ml sodium valproate, 5% w/v DMSO and 16.1% w/v...