Recent content by Thuan

For the record, I have bilateral neurotinnitus, the infamous high pitch EEEE that is in the head but that is not the type of tinnitus I am having issues with at the moment. For about the last year, I started to develop hyperacusis and reactive tinnitus in my left ear. This type of tinnitus is...

Just recently found out about the results from FX-322's Phase 2a clinical trial. I'm quite disheartened but I can't say I'm surprised as I previously had serious doubt and critical view of the FX-322 model. If we all just disconnect from our bias and look at it from an engineering and...

That is good evidence. I like this support to the arguments. I'm glad this is true.

See, the point that I was trying to make is not to say "this doesn't work" but to give a plausible explanation that's different from just a dosage issue for the phase 1 results. It's quite reasonable not to discount actual possibilities that can seriously affect the success of Frequency...

I am not throwing skepticism out there but discussing possibilities that there can be issues. I think my thought processing is logical and plausible. Identify possible issues and see if there can be solutions.

If there's no molecular guide, then I assume it's random. If it's not random, what mechanism will cause them to correctly grow toward the nerve? I refuse to just hope it works. What is the explanation that they just magically grow correctly? Also, there can be a guide but we don't know. They...

I did post the alternative explanation in post #10981. I'll paste it here since there seems to be people not reading completely. Whether you agree or disagree is another matter. But it is an explanation. From post #10981: -- So the basis for my concern is that the new hair cells and the spiral...

I think you are missing an important aspect I'm trying to make. It's not just a matter of a drug plopping down a new neural cell. It's the fact that the new cell need to know where to connect to and connect correctly. There needs to be molecular signals for the cells to guide them to grow...

Again, like @FGG stated, the in vitro study can not confirm if these hair cells are functional. They tell us the new hair cells are proliferating from new progenitor cells, but (as @FGG says in the in vitro tests) can not confirm. They need to confirm it in a histology exam (and I think they...

Yeah, the fact that they did not have significant improvements may show a possibility that not all hair cells are functional. You and I disagree on the term significant. You interpret 10 dB improvement as significant (it certainly is an improvement) but they still nonetheless rely heavily on...

Also, if you think about this logically, if you wasted all your space on faulty new hair cells, then you're permanently screwed. Carl LeBel says there is no overpopulation issue, which means at some point when you reach a population saturation, hair cells will no longer regenerate, either...

I disagree with you on that basis. If there's no evidence shown (in a properly documented scientific paper), I'm not fully convinced. NO assumptions should be made. If I were an investor, then I'm not willing to put thousands of dollars into a company when I have these doubts, which they can...

I don't have evidence. Hence it's my hypothesis for a possible explanation for their phase 1 results. In my opinion, it's a valid and logical hypothesis. You can disregard this if you don't want to discuss all possibilities. And the reason I brought this up is because I have not seen anywhere in...

I'm not saying that they're lying. Have you even read my logic? I'm saying that their conclusion is based on the assumption that new hair cells directly relate to restored hearing. Conclusions are subjective. Why? Because they haven't tested if the new hair cells are all functionally correct...

That is one of my fears. The second is that we should identify all possibilities. I think the data from clinical phase 1 fits more in line with this possibility than not. The fact that there is a majority of people not improving, or statistically improving, or even if there is improvements, it...