Tinnitus Talk Support Forum

Agree. I had bouts of "reactive T" early on. When the H started to improve, so did the reactivity.

@Diesel My reactive T is more akin to a reactive overlay. It is present for any and all consistent sounds (fans, fridge hum, microwave, really everything). It seems like a form of frequency-specific hyperacusis. It stops reacting immediately after the sound ends.

It's odd because the reactivity is very loud, yet my baseline is tolerable most days. I'm not sure what kind of regen medicine I need to fix this.

This is interesting and I think people will have different experiences but my own experience is similar to Diesel's ^. The reactive T flared up when H was worse - particularly in sounds that triggered my facial/trigeminal pain H symptoms the T would become reactive and piercing.

Was always confused how people are able to mask their T with fans and noise, it just makes mine louder

Yeah mine was very similar to your description. Sometimes I still hear it every once in a while, but it did quiet down. I'm still thinking a fresh set of new cells from FX-322 is going to give our auditory system better signals to work with.

I think between hair cell and synapse repair, we should see a significant improvement. Regardless of whether or not reactive T is actually H, it should improve once the structural damage/inflammation is alleviated. I believe loudness hyperacusis will be treated much the same. It all boils down to increasing auditory input.

Got the same mate!

Hoping fx-322 will help my tinnitus/loudness H (which isn't as much of an issue as it's only really triggered by louder environments). Worried it will not work for pain H.

@Sironketchup Sorry to hear that. It's no fun!

@serendipity1996 I think regenerative medicine should positively impact loudness hyperacusis. Noxacusis just seems to be a different beast. Have you been keeping tabs on research related to it?

@Orions Pain It sucks. I can't even go near my fridge without hearing an electrical mess.

It's thankfully loads better now but there's also the worry it could come back! I swear this shit leaves you mentally scarred smh.

@serendipity1996, we really don't know what FX-322 will do for H. Which is still good news. However, from what we've seen in the Phase 1/2, more new sensory inputs into the system seem to improve function closer to normal; better than what we have today.

@Emgee Yeah, I try to. Interestingly, I came across this research summary from a conference hosted by Hyperacusis Research at the 2017 ARO - part of it speculates whether hearing regeneration could improve H (pgs. 6-7) so I don't think we can rule it out. https://hyperacusisresearch.org/wp-content/uploads/2017/03/ARO-2017-Technical-Summary.pdf

@Emgee Paul Fuchs' lab are doing work on animal models to silence the T2 fibers (with retigabine/other drugs) and we have Xenon/Thanos/future Nav 1.7 blockers to look out for in case we need something other than regen.

I don't have reactive T necessarily, just T that fluctuates regardless of sound present which is even more confusing. I think mine is intrusive mostly because I've always been hyper focused on noise (thanks sensory issues)

I really do hope it works for pain hyperacusis. I hope the theory of restoring OHC's will stop pain hyperacusis from happening which FX-322 should work for it.

I completely agree about reactive tinnitus. I have more severe H than T, and I get god awful reactive tinnitus.