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Most of the things I thought helped me probably didn’t make a real difference, except for limiting excessive sound exposure for just under a year. In the end, it was mostly just time that made the difference.

Going strong 👍

Almost 2025, and my hyperacusis is virtually gone. Back in 2021, during my worst period, I could barely go outside for eight months. Now, my tinnitus has improved so much that it’s minimal—just one tone—and I don’t even notice it when I’m in bed. I promise, there’s hope.

Weed no longer causes spiking

I can't directly attribute my 'recovery' to anything except the passage of time. Unfortunately, this is usually the case with hyperacusis, it's about getting the right balance between exposure and silent recovery. I had quite a few setbacks along the way and my ears will forever be more...

I should clarify that I'm not cured of hyperacusis by any means. I still experience occasional pain in my ears and some sound distortions (as well as a quieter baseline tinnitus), but they're not nearly as bad as they were before. I try to stay away from headphones because those can still cause...

Yea I'm back to playing bass and want to start learning electric keyboard (the overtones of acoustic are still a bit too harsh). Electronic drums and beatmaking are other aspirations. I want to study computer science and sound engineering at Berklee College of Music, and eventually open up a...

Free masons were knocked out of power and now we can proceed with curing every ailment in the body, cyborgs, and spatial/oceanic colonization. Once we're done curing ourselves, we can cure the universe.

Mindfulness activities; anything that induces a flow state in the brain. Drawing, reading, journaling/writing, quiet music (if you can handle it), pink noise therapy, exercise (not running), and medications like Zyprexa can help. Dissociatives and psychedelics are potentially worth looking into...

I thought I'd never be able to use headphones again, and I went through a period of about a year where I didn't once dare put a pair around my ears--given that was the original reason I got hyperacusis. However, I'm cured now and use Bluetooth iJoy headphones because they project 4D...

Recreational tripping on DXM (Robitussin cough syrup) about 10 times, and I now take Zyprexa (mood stabilizer; olanzapine) and Vistriol (anti-anxiety). My theory is hyperacusis is caused by cortisol-induced oxidization, which is why mindfulness activities and psychedelics work so well--because...

Y'all probably know my story around here. Suffered alone in a room not being able to go outside because of crippling hyperacusis. I'm all good now and I think psychedelics positively rewired my brain and formed new neural connections. I'm a professional musician now, with extra caution...

Try having both lol.

Well boyos, it's been 10 months with hyperacusis and things aren't looking too good. I've accepted that this is my new life now; no more concerts, parties, restaurants, movies, etc etc. Constant sacrifices and compromises and I'm still left with a shitty, disabled life. I'm only a teenager, so...

I hope not.

Some pretty mega cope in this thread.

Sometime in Q3, probably June-August.

People settle for a level of despair they can tolerate and call it happiness.

Bro, FX-322 or any regenerative medicine for that matter is not coming out before Ebselen. Accept it.

I seriously doubt FX-322 will be out by 2023, assuming it comes out at all.

8 months in and the distortions are still going strong.

CPU: Ryzen 3600X GPU: GeForce GTX 1660 RAM: Corsair Vengeance RGB Pro 16 GB MOBO: MSI B450 TOMAHAWK Case: Corsair Crystal 460X RGB ATX Mid Tower Case Monitor: AOC E2470SWH 23.6" 1920x1080

Typical pop science journalism.

B-but the three super responders from Phase 1! (copes harder)

Lawyer up.

This is making me nervous, I'm getting the Pfizer vaccine soon and have tinnitus/hyperacusis.

Damn bro this post kind of freaked me out, not gonna lie. How are you feeling two days later? I'm not sure there's a way to do this without drilling, since the teeth are under my gums. I'm probably fucked if the drilling is as loud as you say and there's no way to avoid it. Was it the same kind...

I could be wrong but I think CRISPR would only be useful for preventing tinnitus, since our genes have already expressed themselves.

That's a pretty huge assumption. Probably better to hold off on saying those kind of things until the full results Q3. Because people were pulling heavy for this drug to pass Phase 2a with flying colors, which obviously wasn't the case since now the efficacy of the drug itself is being brought...

Definitely a call out to Frequency Therapeutics.

What's a realistic timeframe for the first version of SPI-1005 to come out? 2022?

Did this person also have hyperacusis? Surprisingly I haven't found many people online in my scenario. Right now the situation seems kind of lose-lose, so I appreciate you and FGG's advice. I will discuss further with my dentist about how necessary the operation really is and the risks vs...

Because I'm 17. They haven't pushed all the way through yet. The teeth haven't posed any problem as of yet. I don't know the dentist's reasons for wanting to get them removed, but I presume if they continue growing into my teeth it will cause headaches and crowding. I'll have to weigh the risks...

I'm no dentist, but it seems like the problem is that they're growing at a 45 degree angle in the direction of my teeth. I agree that I'd much rather keep my teeth as they are to avoid any loud drill or suction, but I'm also afraid that the surgery may be necessary given the direction they're...

Tbh I wouldn't set your expectations too high for either drug. The odds are against them and you could wind up falling on your face pretty hard.

I have two lower wisdom teeth that are growing in sideways. In about a year I'll need to get them removed from my mouth. The problem is that I have pain hyperacusis, reactive tinnitus, and very weak ears in general, and I'm certain that the drill will considerably set me back. I've considered...

Based on what? FX-322 was not the smashing hit anyone here or at Frequency Therapeutics thought it was going to be. OTO-414 was delayed by a year or two. Other trials are still years behind. I'm not optimistic for Neuralink by the way, but I feel like the people making these kinds of statements...

God damn, going to have to wait another two years for this stuff to come out, and that's assuming it gets FDA approval. Not sure if I can do that. I don't have $5k to throw at a shady Chinese lab.

I don't disagree, but I'm not going to invest my emotional health in a drug that won't be available for another one to two decades.

Ebselen is probably the only clinical stage drug I'm still keeping my eyes on.

Tinnitus Talk before day 90 results: "Multiple injections will surely push the gel deeper into the cochlea." Tinnitus Talk after day 90 results: "Multiple injections actually clogged the ear, this time fewer injections will work!"

So you literally want an echo chamber around FX-322 because you're too afraid to hear the opposing viewpoint?

What is the mechanism of action for channel blockers possibly ameliorating hyperacusis?

It's called corpspeak.

Are there really zero labs out there selling Ebselen to consumers? I scoured the internet and found some websites but they either looked shady or were only selling to researchers. There are people here willing to shell out $10k just to see if it works and we still haven't managed to find a...

I was just explaining why Frequency Therapeutics could not have included that on the interim. 10 dB doesn't seem that great to me and could very well be a natural fluctuation in hearing or within the standard deviation for the test. Last time we got overly excited about anecdotes I'm pretty sure...

Wait until the day 210 readout. If it turns out to be effective, then great. If there are no clinically significant improvements, it's safe to say the drug is a bust. Otherwise, go for the CI; what's important is that you improve your quality of life with the tools you have available to you...

Give me all of that if it improves noxacusis.

It was outside the timeframe to be considered clinically significant. They aren't able to count anything outside of the data parameters they set.

Hopefully they take notes on the disastrous FX-322 trial and change their methodology accordingly.

Sad but not surprised

Nothing has to happen, the universe doesn't owe us anything. Our suffering and emotional investment means nothing for any of these drugs.

Looks like Ebselen is the last man standing.

Does anyone else figure this thread will sizzle out and die like the Lenire and Audion Therapeutics ones if day 210 results are just as bad? The only drugs I remain hopeful for are Ebselen and the reformulated Trobalt. Now I understand why veterans are so jaded towards miracle cures. It just...

First stages of grief: shock, denial, bargaining.

On the other hand, I spoke with a guy who had the Silverstein surgery done on one of his ears and is doing great now. He had loudness hyperacusis and some pain before, but now he can drive, listen to music, and eat at restaurants, no problem. It's worked so well he's considering getting his...

Any morning now we wake up, the results will be out guys.

Imagine someone saying that subtyping is harmful for any other condition.

Probably not.

I'm enjoying the discussions going on here, definitely one of the higher quality Tinnitus Talk threads I've read in a while. I share @Zugzug's distaste of gatekeeping hyperacusis, or in other words competing in the suffering Olympics. I myself have been guilty of doing this in the past but now...