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Because cochlear implants are expensive, remove all your hearing; even the healthy part. Then, it is still "artificial hearing" and it is a lottery at the moment for tinnitus. There are even some people who had their auditory nerve sectioned in one ear and still have tinnitus in that same now...

I have little faith in Neuralink but I would like them test it on volunteers with tinnitus to see if it helps. Depressing how things progress so slowly.

Any news about this trial? Completion date was July 2022 according to ClinicalTrials.gov.

What is the status of Neuralink? Are they waiting for FDA approval after the tests they did on chimps? Or do they need to do more trials on chimps before trying on humans?

The story repeats itself.

Well, Phase 1 OTO-313 results were positive but didn't look so fantastic, so I didn't have a lot of hope in this. But, at least, the trial was aiming for tinnitus cure as the goal. And indeed, there are few studies that aim for that. Most the stuff about Kv7, OTO-413 and even regenerative...

How can you have such a difference between their numbers (~90% people that recommend Lenire) and the overall feeling on this forum (very bad reviews from most who have tried it)? I know that people who had bad experiences are more likely to share it but the difference is really too big here...

If they don't exclude people with tinnitus, just apply to it, yeah...

Thanks for sharing. I'm not sure I understand the "late 2023" deadline here. Is this deadline for when they will start to apply FDA for Phase 1/2/3 with their procedure? What kind of surgery is needed here? Does this require two severe surgeries like DBS? Because I guess they have to drill a...

Anyone with epilepsy + tinnitus tried this yet?

Okay, I just listened to it so it is actually 4 years before they start to try it with humans in a clinical trial. Probably you'll need to double this time to get the human trials done and make it accessible to public if it's working. Well, that's a very long time waiting but at least they are...

I haven't heard the podcast yet but I have read the comments. And this "4 years" timeframe is unclear to me. 4 years before their device is available to public or 4 years before they start human trials?

What is PGIC on the graph?

"Bringing a device to market takes an average of 3 to 7 years, compared with an average of 12 years for drugs." Well there is a huge difference between a device used outside the body like Auricle aim for and a device that requires an invasive surgery that need to open the skull and implement...

"making them suited for high-resolution recording and stimulation of the brain for up to thirty days." It only stimulates the brain for thirty days? I don't get it.

Red flags everywhere.

If only...

I wish it was a tumor for me.

Tbh, if Dr. Shore's device works in either eliminating or strongly reducing tinnitus (not a shitty improvement you can account for placebo), I don't care waiting another year or maybe two as long as we have something to get out this hell...

The fact Dr. Shore and her team have spent so much time on this device trial (20 years+) worries me a lot. It's non invasive procedure so if the results were good, I guess it would already have been on the market years ago.

They don't know the results for Phase 2 yet. It's double blinded.

Any news about the Phase 1/2 results? I checked ClinicalTrials.gov and they don't talk about results. In the meanwhile, it's listed as "completed" since few months now.

Think it's Kv7.

Dr. Ridder still has the afternoon to release something.

OTO-313: early onset tinnitus OTO-413: having tinnitus is exclusion criteria

So i have read some pages from this topic and if I am right, OTO-413 seems to only target acute hidden hearing loss, not chronic?

Maybe Neuralink will be useful in the future for tinnitus. But after watching some conferences and talks where Elon Musk has debated, the timeframes he has given are absolutely not realistic.

I'm afraid Dr. Shore's device will be a repeat of Lenire. In my opinion, I think neuromodulation can't cure tinnitus but maybe reduce symptoms at best. If it does reduce symptoms, I hope it will have way better results than placebo and that it will be peer reviewed etc. For a complete cure, I...

They seemed to have great results in this study. Do you know why they didn't push forward?

I got my tinnitus just like you 2/3 days after a dentist appointment. My jaw was opened a lot of time and i tried to open it as widely as I could to facilitate the dentist's job during the medical exam. Maybe the fact that we opened our mouth like that prevented our ears from protecting...

Stress induced tinnitus is bullshit imho. Everytime something wrong happens in the body and that docs have no clue about what is going on they say it's stress induced. Did you go to a concert or did you have a dental appointment before having tinnitus (dental cleaning too)? Also do you often...

Are you sure there was a mosquito? Because my tinnitus started like this: I was sure there was a mosquito roaming badly one night but I realized it was tinnitus after.

Any day this year or the next one?

OTO-313 won't be a cure for sure. But if it can help some people reducing their tinnitus level, I'll try it.

Yes, this seems interresting, especially when we know some people after getting cochlear implants had complete suppression of their tinnitus and the majority had great improvements. Such a pity all those clinical trials take place in the US though.

Why do they develop so many electrical devices like this? So far we have Lenire, which is already out. We have Dr. Shore's DeNovo coming, which has been in development for years, and this one mentioned in this thread that I'm aware of. I'm pretty sure there are even more electrical devices in...

Why does Lenire cost so much money? The device looks pretty cheap imo. I would have liked to try it to see if it can reduce my tinnitus but why do they ask such a high price? My assumption is they are scamming people...?

I think that they just have no idea what's going on in most cases of tinnitus.

The hearing test is kinda useless imo because it only shows up to 8 kHz and doesn't actually show the real state of your ears (nothing can yet).

I should have asked this earlier, but what's OTO-413's first goal? Hearing loss or tinnitus? If it's for tinnitus, is it for acute or chronic one tinnitus?

All drugs are in phase 4 once released.

Why do they call it phase 2"a"? What does the a mean?

I think FX-322 has good chances to restore at least a part of hearing loss (higher frequencies) but I'm so afraid when it comes to tinnitus. There are so many "what ifs" involved to solve this curse. I truly hope I'm too skeptical but anyways we'll know in Q2 of 2021.

Ye its always scary when you realize the thread was created ages ago

For how long are they dosing/following patients in phase 2a?