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Thanks for your concern. As much as I like hope, I dislike false hope even more. However, I suspect many members of Tinnitus-Talk prefer false hope. Or so it seems to me............... P.S. I believe you will win the lottery tomorrow.

I doubt it went. Someone having a "doubtful" mood and writing 16 messages upon registration with a tinnitus-forum probably still has tinnitus (pretty bad).

Dude... there is an endless number of people (politicians and otherwise) suffering from tinnitus. Now and 20 years ago. Just like there is an endless number of people suffering from cancer and degenerative diseases of the CNS (and many other "things").

Jack Straw (former interior minister in the UK) developed severe tinnitus after sudden hearing loss on a flight. Bill Clinton (former US president) has tinnitus. Mrs. Carter (former US first lady) has tinnitus. Martin McGuinness (deputy prime minister of Ireland) has tinnitus. ...and the list...

Agree on all points. but in addition, I would say that one extra worthwhile point to ask would be: what was the result in terms of tinnitus improvement? And why not state it in the first place...

Hey - you are free to choose what you want to believe. if you ask me however, I would be more concerned about an infrequent poster suddenly making an entry about a stem cell treatment after no activity since december 2014 seems weird that someone would join the board after no activity for a...

I have one post in this thread - and from that - you deduce that I am also posting as attheedgeofscience? Interesting...

Wading through all the half-brain posts on an Internet forum, two specific quotes come to my mind (I wonder why):

No, you didn't say anything about LASIK. I did. But, you stated that... ...and I am letting you know that there is no such thing as floaters on the surface of the eye (from the point of view of laser surgery). You clearly have no knowledge of the subject at hand, and so why not just stay out...

Floaters "float" inside the vitreous (the jelly-like substance of the eyeball), not on "the surface of the eye" - whatever it is you are referring to (the cornea, presumably). Laser surgery in relation to eye floaters has nothing to do with eyesight correction of the cornea (so-called LASIK...

Dude... if you check just one page back, you will find the following information:

Reading through a random 25 introduction posts on this forum will leave the average reader with the impression that tinnitus will get better with time (never a shortage of members to point that out) - here is a prime example...

Well, "Dr. Google" does a better (and also more prepared) job of explaining that. Hyperacusis is sensitivity to everyday sounds (that would not cause irritation in healthy people). Tinnitus is commonly correlated with hyperacusis (but not always). Here is an extreme example of what it is like...

Sounds like you have developed hyperacusis.

Well, you can calculate it backwards from this slide in the recently released material pertaining to the Needham Healthcare Conference held earlier this year: Market potential = 750M dollars (for an associated 250,000 ears). That's $3000 / ear (and hence where the $6000,- figure comes from I...

Fully noted. And thanks. But then that is not the question. I know exactly where the value of $6000 comes from. My main question is how does @monacco know?

Neither do I, I must admit. And I just did a search for "6000" in this entire thread with the search functionality that XenForo is equipped with. So I doubt you read it here on the forum.

I'm curious here: how do you know the price for a drug that is not yet on market would be $6000...?

Given that the AM-101 study ever only accepted patients with onset of tinnitus up to 12 months, I do wonder how he managed to get on to the trial... https://clinicaltrials.gov/ct2/show/study/NCT02040194 a (concerned) passerby

Hmmm... your logic is equivalent to saying that only terminally ill cancer patients visit www.cancerforums.net or that you would never find severely impacted diabetes patients not visiting http://diabeticnetwork.com/community. Perhaps quite a few tinnitus patients simply have no interest in...

If you want facts, then you need look no further... www.tinnitustalk.com/threads/survey-results-rate-your-tinnitus.9803 www.tinnitustalk.com/threads/survey-results-tinnitus-talk-mini-survey.7904 In particular, pay attention to chart #4 in the 2nd link above. a (concerned) passerby

"It doesn't actually get louder..." Excellent. In that case there would be no need to ever wear earplugs at a concert once a person has first contracted tinnitus. Wanna be the first to test the hypothesis...? I am sure I can locate the next AC/DC concert for the purpose. Do let us know how you...

...and don't forget to count in all the idiots who didn't understand what tinnitus is on their first "iteration" of the condition: "Tinnitus...? Nahh, who cares. Why don't I attend another concert just to prove to myself that it can get worse..." :rolleyes: Undoubtedly, the last fool has not...

I think you need to look into some basic differences in clinical diagnostics between tinnitus patients and non-tinnitus patients. Key words: fMRI, highres EEG scans, prof. Jeanmonod, brai2n clinic. If you do, then you will see that it is real. a (concerned) passerby

Okay... so this is pretty straightforward: when a tree crashes, it does not produce a sound, it produces a sound wave. Sound is something which is perceived. If there is no one around to perceive the sound wave, then there is no sound. a (concerned) passerby

It's basically not about drugs (at least not specifically SF0034), but about identifying ion channels responsible for the induction of tinnitus. As a specific note is the involvement of a new channel, HCN. "Our results highlight KCNQ2/3 and HCN channels as potential targets for designing novel...

Epic comment... like reading some folks messages on Facebook: "Going to do some gardening today" then 15 min. later: "Oh no, it started to rain. Guess gardening will have to wait!" This thread is 90% trash-talk. A kindergarden. No wonder folks like @attheedgeofscience left. a (concerned) passerby

...And even if he did, there is no way I would know where to look with his +3000 posts consisting of one-liners! a (concerned) passerby

Perhaps some folks on TT should consider getting themselves a job with the CIA or buying a copy of the story of "Woodward and Bernstein". Clinical trials are conducted in a fully transparent and open manner: there is no hidden or secret agenda, nor are participants required to sign...

Potassium channel modulator drugs require the patient getting used to them. Cognitive side-effects will wear off to some degree (with time).

CBT is a fundamental part of TRT? Not according to this: www.tinnitustalk.com/threads/trt-or-cbt.8517/#post-117678 a (concerned) passerby

No.

given the following observation, good luck with that:

He is... G O N E . . . Yes... according to his own interpretation, that is. Listen... tinnitus depends on many factors - incl. the frequency, centralization in the head (as opposed to the ears), etiology (head injury vs. noise), pulsatile/non-pulsatile, as well as the psychological component...

As some may have noticed, Autifony Therapeutics Ltd and Otonomy Inc are present on the social media channels. It is super simple to show your support by rating their facebook pages: www.facebook.com/Otonomy www.facebook.com/pages/Autifony-Therapeutics-Limited/1613600998914391 It is also...

Noted. And agreed. However, according to the expert of all experts, Dr. Nagler, when it comes to "Tinnitus and TINNITUS" there is only tinnitus: a (concerned) passerby

That must be the Tinnitus Research Initiative... www.tinnitusresearch.org/en/contact/contact_en.php

KCNQ = Kv7... (which you yourself pointed out earlier on). So KCNQ2/3 = Kv7.2/3. Hence SF0034 is a drug with higher selectivity than Retigabine (and hardly surprising given that it - SF0034 - is a derivative of Retigabine...). I don't think you actually have any idea what you are writing in...

You have answered your own question - if by "KV3-2" you mean Kv7.2/3 (which I assume you do as KV3-2 is not a proper reference to a Kv-channel...): Again... I don't really know whether you are referencing a Kv3.x- or a Kv7.x-channel. And who is "they"...? I don't know... where does it say it...

there is actually a section III in the netiquette of the forum which concerns the accuracy of information posted: www.tinnitustalk.com/threads/netiquette-of-tinnitus-talk.1070

SF0034 works on Kv7.2/3 - and hence - is also a Kv7-channel modulator, like Retigabine (but does not carry the same side-effects as Retigabine). a (concerned) passerby

True. But that - liver toxicity - would have been known in advance of the study (and hence is besides the point). If a drug is going to be studied for specific purpose (i.e. symptom treatment) dosage needs to be considered. Otherwise, there is not much point in doing the study in the first place...

Only 200mg / day were used in the study. Which is 1/3 of the maximum dose. The study proves nothing (except that Flupirtine is not effective at those doses....). a (concerned) passerby

Not sure why 9 members rated the quoted post "informative" when there are several passages that are wrong (and which would have been easy to verify - for anyone...). See this literature if in doubt: http://bps.conference-services.net/resources/344/3046/pdf/EPHAR2012_0621.pdf Retigabine is a...

as a frontal view of the head (face), the MRI scan is perfectly normal. Not sure what "extra set of eyes" you see, or, are referring to. Certainly LLLT cannot grow eyes in the brain. a (concerned) passerby

speaking of cures, is there any reason you didn't bring your own tinnitus cure to the surface? would seem rather relevant (and newsworthy) for a tinnitus forum, wouldn't you say...? Description on youtube reads: "[UPDATE] I no longer have tinnitus. I had an experimental procedure performed...

The phase-II trial is looking for a total enrollment of about 150... https://clinicaltrials.gov/ct2/show/NCT02315508?term=quiet-1&rank=1

I am glad you reached the conclusion to your own question by yourself... :)

Just how would a donation help...?

see my comments to you from my profile page (which is "awaiting moderation" for some reason...). see also this response from the expert of all experts on TRT, Dr. Nagler: seriously... how futile can a response get? try replacing "tinnitus" with "cancer" and tell me what you think. Did you ever...

thanks for the info... just for my own understanding, do you happen to know what the following photo shows then? www.tinnitustalk.com/threads/hifu-high-intensity-focused-ultrasound-surgery.276/page-17#post-111028 When I first saw the photo, I assumed that the gauze bandage was from the...

thanks for your informative posts. speaking of money, what did the "project" cost? Can you disclose that at this point? How long was the wait between screening and surgery. thanks.

These articles question the basis on which tinnitus is measured in animal models. And hence the articles question whether the pre-clinical studies demonstrating efficacy of compound x,y, or z live up to their promise in the "human test lab" so to speak...

None of them. You are referencing the CLARITY-1 trial...

I know which of the two choices that taste better...

No team trobalt icon below his avatar. I read the information tab on his profile page: highly informative. the depth of his knowledge (and personal experience) is impressive. It says at the end of the page that he has left the forum... A (concerned) passerby

i must have read the same thing. A (concerned) passerby

I don't think it is due to my privacy settings. never changed them. Instead it is due to restrictions on my profile for some reason. I was told by another user of tinnitustalk how to PM someone, but I don't have the features the person mentions - see this screen print (if in doubt): I know...