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This is the official clinicaltrails.gov page for the phase 1 trail of XEN1101 (with TMS): https://clinicaltrials.gov/ct2/show/NCT03468725 The fact that they included TMS to check for empirical evidence of drug delivery in the brain is a real game changer and gives confidence in the...

Good news, but dont forget: One case is no case. Placebo is often a good but temporary remedy. The internet is full of trolls.

Well... in the 'dark scientific age' we live in, pre-clinical trails on animals who can't tell us if they have tinnitus, nor if any intervention is effective in supressing it, are considered common practice in drug discovery. Take in account that a substantial part of medicines now in use are...

At least.... an article that explains the Shore method thoroughly and understandable for Joe and Jane: https://jamanetwork.com/journals/jama/fullarticle/2675187 My opinion for the viability of this method (don't want to crash your party but): The population count of 10 control and 10 actual...

Well ladies and gentleman... AMother-101 bites the dust: http://hearinghealthmatters.org/hearingnewswatch/2018/auris-medical-disappointing-tinnitus-drug-trial-results/ Stay calm, be patient and walk away.

Just a quick update regarding XEN1101. Recruitment for the phase 1 trail has apparently started a month ago @RichardsonLab in London: http://epilepsy-london.org/clinical-trial-new-anti-epileptic-drug/

Well... this is confusing. Apparently in treating T Aut63 turns out to be a very effective drug at lowering the symptoms as much as 60%... for hamsters...: https://www.ncbi.nlm.nih.gov/pubmed/29453003 If they only could make this work for humans I could finally stop wasting my time on PubMed...

Let's make that specific then. Where does funding for tinnitus research come from? The department of defence...national health services?? The first funds research because the payout for debiliated soldiers with noise-induced T costs on the long term much more money then finding a cure (they are...

This was only an anology. An example to explain that damage in the inner ear could trigger an overamplification in the brain to compensate for loss of signals from the cochlea. The result is no measurable hearing loss, but a lot of hisss... like turning the volume of your anologue amplifier way...

Nobody knows besides Autifony. Time will learn us.

Finally.... somebody that can reproduce my experience ;) But to avoid false positives you first need to try the 'sweep experiment' with different headphones. Many headphone producer's tweak their products by playing around with the sound profile (for example they bring the bass to the...

Yes No, at least not the sound I perceive. Because it is not probable that damage in the cochlea/nerve/brain is pinpointed to one frequency. A whole range of tissue will be damaged more or less generating phantom sounds on multiple frequencies with different volumes and causing a peeeeep...

Yes, that's exactly what they have written.... and it is a fine example of scope narrowing due to risk avoidance. Modern research is influenced by profit driven stakeholders who don't care about progress but are purely intrested in money. Because of this researchers tend to narrow their...

Bumping this thread because there is a new paper on PubMed about KV3 and tinnitus (Charles Large is again one of the authors). The generation of tinnitus in the brain is once again linked to the fusiform cells of the DCN (Dorsal Cochlear Nucleus). This is also the underlying theory in the...

Keeping myself busy with work, listening to music or walking outside (rich ambient noises work like a charm). When at home I use smartphone apps: Relaxio (especially the white noise app) https://play.google.com/store/apps/developer?id=Relaxio&hl=en Signal generator (1300hz square sound for 5...

Found this paper on Pubmed published yesterday (unfortunately no abstract): Sensory systems: Bimodal cochlear nucleus stimulation alleviates tinnitus. https://www.ncbi.nlm.nih.gov/pubmed/29348542 Somebody know if it is related with signal timing or not? The author is Heather Wood.

This confirms my earlier post. They have no clue if kv7.2 channels are the holy grail for T, but the fact that Retigabine did something for some people is a lead they are pursuing with animal models.

Don't get disappointed if phase 1 doesn't show a noticeable effect for tinnitus. Phase 1 trails are purely intended as a safety check for drug candidates. The dosing could therefore be lower than the therapeutic value needed for effective treatment. Phase 2 will be important because it's goal...

Well... a recent (december 2017) researchpaper still reported positive effects of kv3.1 modulation with aut63 (failed in trails) on fast spiking neurons in the auditory pathway (read: tinnitus). The abstract of the paper is accessible on pubmed: https://www.ncbi.nlm.nih.gov/pubmed/29235497/...

No... the compound is called ketamine and they are injecting it intravenous (directly in your veins). AM101 is called esketamine and is injected into the middle ear. This is also explained on the clinicaltrails.gov page I provided with the link... please read first...

New trial with Ketamine IV injection for the treatment of T started by New York State Psychiatric Institute. More info @ https://clinicaltrials.gov/ct2/show/NCT03336398?recrs=abdfm&cond=tinnitus&draw=3&rank=28 P.S.: Anybody any experience with this stuff??

They listened to you Karrie... New trial in New York started by New York State Psychiatric Institute. More info @ https://clinicaltrials.gov/ct2/show/NCT03336398?recrs=abdfm&cond=tinnitus&draw=3&rank=28 P.S.: Anybody any experience with this stuff??

Please stop spreading BS from depressed feelings without any factional arguments (referencing to WW2... yeah right). This is the chart on PubMed showing the number of research papers since 1979: And this is the same chart projected on an exponential curve: Do I need to say more... a cure...

Yes, the man is still alive and working on Kv7.2/3 channels ;) http://phrc.pitt.edu/people/thanos-tzounopoulos By the way... the brand new website of Pittsburgh Hearing Research Center is also worth your visit: http://phrc.pitt.edu/ P.S.: New drug target is also sighted. Blocking those nasty...

No... not yet... but with our help some day they will... and with them we will...

Dr. Christopher R. Cederroth from the Karolinska Institutet in Sweden published an article about the fact that the tinnitus topic on Frontiers gained more than 1 million views in a relative short period: https://blog.frontiersin.org/2017/10/24/frontiers-research-topic-tinnitus/ Interesting...

It's official ladies and gentlemen... phase 1 trial of XEN1101 (formerly known as 1OP-2198) will start in Q4 2017 with phase 2 following in second half of 2018. Initial for epilepsy targeting Kv7.2 channels, but who knows... maybe a miracle for tinnitus could also happen. More information on...

Good news... but it is still wise not to launch kv7 regulating drugs as the new holy promise of tinnitus treatment. Back in 2011 there was an experiment in which Maxipost and it's R-enantiomer (opposite) were both effective in reducing salicylate induced tinnitus in animals. The theory was that...

Hi @TTP, first of all... don't panic. Your T is just 3 weeks on and there is a possibility it will go away (T less than 3 months isn't considered chronic). I won't recommend you to do research on this stage because it could make you more anxious and flare your T up. My advise for you is to try...

Who knows... from a logical point of view one could expect that the pre-clinical study probably only focused on the neurochemical regulation of kv7.2-7.3 channels on cellular level. Next step is to proof safety for use as a medicine (hence the analogs) and test it's efficacy on different...

Status update for RL648_81:

No. The drug that Tzounopoulos developed is RL648_81 (no news about it since Q2 2016). This one is aquired by Xenon pharma last April and is since rebranded as XEN1101. If everything goes as scheduled fase 1 trail will start in Q4 this year...

Thanks for sharing your experience @Cal18 (y) Regarding the use of Olanzapine I can share that a close friend of mine who also suffers from T unfortunately has not benefited from it. It is probable however that a combination of dopamine and sertraline medication could be beneficial for some...

Movie is a hit!!! Everybody to the cinema for more awareness (and don't forget the earplugs).

Mirapex = Pramipexole = https://www.tinnitustalk.com/threads/tinnitus-control-by-dopamine-agonist-pramipexole-in-presbycusis-patients.84/

Thank you very much that you made me laugh for the past 5 minutes @NatureHiker . Your capability to invert things up is wonderfull. Now... if you don't mind a little critical remark... would you please place your posts about BHV-4157 in the threads that are available for this compound. To help...

Wow... @NatureHiker ... you do have some good qualities for dramatizing things up, don't you? Pittyfishing in a pool of likeminded won't help in this. What helps is avoiding sophistry and doing solid research before posting things. Thinking before you come up with something is not about...

Might have this...might have that... big pharma behaviour as usual... Maybe they can also add to the list that this new drug might be improve our chances of winning the Powerball lottery... And @NatureHiker ... nobody is barking at you... it is just a small request for more focus on evidence...

The phase 3 trial is about BHV-4157 (Ataxia) and not about BHV-0223 (ALS). Also don't know why this thread exists since the candidate compound is not purposed for tinnitus (with this logic we need to add every one of the 100 trailed drugs that enacts on the brain...). So... please read and...

They received an additional 20M$ :rockingbanana: for more research on hearing loss (and I hope tinnitus also). More information: http://www.masseyeandear.org/news/press-releases/2017/06/gift-to-mass-eye-and-ear-among-largest-for-hearing

There are all ready evidence based locations in the brain that are been identified by neuroscientists. One of the most interesting of them (stimulation of area-LC on the caudate nucleus) is discovered way back in 2010: https://www.ncbi.nlm.nih.gov/pubmed/23082889 ... and in California they are...

Thanks for your very informative explanation. (y) Big data computing is exactly the way to go. The complexity you are describing is however due to the absence of interdisciplinary cooperation. As you also describe drug discovery nowadays is stooled on the same stone age principle of random...

An impressive and scientifically correct analysis you made above @Biomed. You seem exactly the right person with the right academic competencies and attitude to give discussions a new impulse on this forum. Unfortunately I don't have a degree on biomedical sciences but after many hours of...

Bumping up this thread because of a trial that has been going on in Regensburg Germany since 2015 with expected results in December 2017: https://clinicaltrials.gov/ct2/show/NCT02615600 Any members on tt that have attended this trial in Germany??? ...and if yes... what are your experiences???

Could you also inform us with a little bit more information about your experience: Which 2 meds were injected? For how long did you have tinnitus? What is the character of your tinnitus (pitch, both sides/one side, constant/changing etc.)? Note For everyone else: please describe your...

This thread is not about Alprazolam (Xanax) but about Aripiprazole (Abilify). There is a huge difference in the mechanism of action between those 2 drugs!

Ok ladies and gents... time to share some interesting insights about a drug called Aripiprazole (aka Abilify) and its effects on our old friend Mr. T. About a month ago I stumbled upon the tweet below on Twitter that sounded like silence in my ears. Asked right away for more information and got...

A little remark about the effectivity of HA's in reducing your T sound. Probably it is due to auditory masking which is a build in feature of our beautiful brain. It is the main reason why compressed audio (like mp3's) sounds the same (well... If you are not an audiophile off course ;)) as...

Quick update: The phase 1 trail of this compound is set to take place in Q4 2017. The compound is licenced to another company called Xenon pharma and is now called XEN1101. More info...

Yes, that is exactly the problem... there are enough scam artist's with a PhD on... let's say chiropracty... that call themselves 'Dr'. The average man doesn't know this and thinks advice is coming from somebody with a genuine medical degree. My advice: it is possible that you believe in any...

My dear Samir... the title of the article says 'is there a place for brain stimulation' with respect to tinnitus and the article has been published on a website about neurosurgery.... so... of course the article discusses the possibility of treatment thru surgery. If this didn't make you happy...

So... I see that you are interested in the last insights about the neuroscience of tinnitus... Here is the link to a research paper written by real M.D.'s and based on hard evidence... ;) http://surgicalneurologyint.com/surgicalint-articles/tinnitus-is-there-a-place-for-brain-stimulation/

I know a person who took Pramipexole and it diminished/lowered their tinnitus effectively. The summary of the case is: The dosage the man used was 0.25 mg pill 3x / day He also used Amitriptyline as a med next to Pramipexole (this combination of meds could also be important for his experience)...

Just saw this on Twitter. Could be interesting to get more insights about research that has been conducted by NIHR. Somebody nearby Nottingham who could attend Prof Baguley's lecture and report back?? (@Steve maybe :) ). Full link to more information...

Exactly my point of view Steve. As popular as Elon Musk is, he probably receives hundreds or thousands of messages every day. The chance of getting his attention for our condition with 3 or 4 tweets isn't probable... but with hundreds of tweets in a short period and with the right #hashtag we...

As I like to be a liaison for connecting similar trials, below a fMRI research in Groningen (The Netherlands) for gaze evoked tinnitus: Right now they are also doing research to test the possibility for implants to silence unilateral tinnitus. Thanks and keep up the good work Steve!!!

The man has built a reusable rocket with limited budget in a decade while NASA hasn't done anything innovative since the 70's with a budget that's comparable with the budget of a small country. Therefore we could expect Neuralink's progress to be faster then conventional science...

Couple of weeks ago Neuralink, the new brain to machine start-up Elon Musk has created, was on the news. In the meantime a new website has been launched for the company: https://www.neuralink.com/. Eventually they are searching for talented people to start their activities (If you are a...

To be honest I don't think pharmaceuticals care about young people getting their T from iPhones or veterans getting them from machine guns and bomb blasts. They care about a large enough customer base that can turn their investment in profit. Nobody can blame them for this because in the system...

To be realistic... I think it would take another 5 to 10 years for approval of an effective drug... especially because of the unfortunate fact that nobody besides the tinnitus suffering community are considering a cure urgent. But... there are other initiatives right now that are focussing on a...