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Sometimes even big organizations can overlook smaller discoveries. I've been trying to contact Frequency Therapeutics etc via email and other social media for ages and haven't heard back if they are aware of Otomagnetics. The chain of communication needs to be infiltrated somehow, and podcast...

Frequency Therapeutics drug FX-322 works! Their trials had difficulties because of their injection method not being effective enough in getting more of the drug inside the cochlea. I really believe this will solve that problem!

Hey everyone! Here's some recent updates to Otomagnetics progress!

I've been saying this countless of times and have sent several emails to Frequency Therapeutics asking if they are aware of this development. I haven't heard a single thing back. Someone has to print off a bunch of Otomagnetics business cards and physically dump them all over the desks of folks...

Watch this video about the system's concept:

See my other post. The problem is the delivery, not the drug itself. Otomagnetics delivery system is the answer to getting it working! But no, I guess I'm not loud enough to catch people's attention with it.

I said it before, this type of delivery system looks like it could solve the problems of the injection method: https://otomagnetics.net/about

What are the odds that insiders from the hearing aid industry negatively influenced parts of the trial to turn it out negative? Like Slugworth from Willy Wonka but instead, convincing participants to lie for reward?

Agreed x100.

Today's event link: The Potential for Restorative Treatments for Acquired Sensorineural Hearing Loss

Your extended audiogram only goes up to 12.5 kHz, but the full range of testing in more specialized clinical practice is up to 16 kHz (before standing waves can interfere with reliability of measurement).

I can see your point, in my hypothesis, the psychedelic therapy would speed up the re-conditioning and recovery of depression and anxiety, which are highly correlated to tinnitus. As commonly known, some people without hearing loss (even when tested in the high frequencies) still have tinnitus...

Many of the psychedelic drugs being decriminalized such as psilocybin, ayahuasca, and MDMA have been showing potential to relieve tinnitus by rapidly re-wiring parts of the brain that respond to anxiety and threat detection that causes the tinnitus feedback loop. Not only that, but effective for...

Any updates on FX-322 trials in Canada?

What do y'all think about the tone of this article on Frequency Therapeutics? Don't Shout Yet: Drug To Regenerate Hearing Shows Early But Muted Promise In New Trial

Frequency Therapeutics Announces $42 Million Private Placement

Anybody planning on saving these recordings? https://www.businesswire.com/news/home/20200527005123/en/Frequency-Therapeutics-Present-Upcoming-Investor-Conferences

That's still progress though! I'm glad they are aware of FX-322 and hope there is some degree of good communication between Otomagnetics and Frequency Therapeutics!

It's a case of "complacent doctor arrogance." Not to make a blanket statement for all ENTs, but it seems a lot of the older ones or middle aged have dug themselves in a clinical rut where they just don't care about research as much as going through the day to day motions and collecting a...

Sorry I didn't see that you already posted this, I impulsively posted the same link without reading this page of the thread haha

https://journals.lww.com/thehearingjournal/Fulltext/2020/05000/Defining_Different_Types_of__Hidden_Hearing_Loss_.8.aspx An interesting article on the different "types" of hidden hearing loss

This looks like a promising future technology for better drug delivery: https://otomagnetics.net/about

I think the main cause of stress induced tinnitus or hearing loss is that stress suppresses the immune system which leaves you more vulnerable to infection and viruses. Both some known and many different unknown viruses can cause damage to the auditory system via nerve inflammation and damage...

Hello everyone, I am going for testing to see if I may have asthma as it runs on my father's side of the family and I have been experiencing periods of shortness of breath in the evenings for over 7 weeks now, even with negative covid-19 test results. Part of the test involves comparing airflow...

The problem with these YouTube hearing tests is that YouTube compresses audio data and adds a low-pass filter at 16kHz. Anything above is rolled off and cannot be heard accurately even in people with healthy hearing at high frequencies. This one is full-fidelity...

Is there any correlation between hidden hearing loss (due to synapses damage) and loss that appears on an extended high frequency audiogram up to at least 16kHz? My thoughts initially were that they call it "hidden" because rarely any clinicians measure beyond 8kHz. It always irritated me when...

Go to a different emergency ENT as steroidal treatment for sudden hearing loss isn't something that should be delayed: https://www.dana.org/article/reversing-sudden-deafness/ https://www.health.harvard.edu/diseases-and-conditions/now-hear-this-dont-ignore-sudden-hearing-loss I also get these...

Since I am not able to access clinical extended high frequency audiograms up to 16kHz, I can only guess that my tinnitus plus ear fullness (verified no physical blockage, wax, nor fluid) is due to damage of the synapses that are attached to high frequency detecting hair cells near the base of...

Thank you for your response I really appreciate it! Although I am in a desperate position to jump with the first treatment that comes out, my core beliefs and views align with the models of non-profit organizations. Since I'm from Canada, I'm also curious about what the process would be like...

Watch this video: https://otomagnetics.net/about Still in R&D

No mention of Canadian trials? Or would that be included in further trials with the U.S.?

Just a question for any Canadians that are familiar with drug approval process. Would the fact that FX-322 is fast tracked by the FDA hold any weight in getting it to Canada within a few years? I would hope the safety data and efficacy evidence would be enough but I heard each country has to run...

There is a lot of reasons to fix that. 1. Energy in ultra-high frequencies is important for clarity especially in social environments and rooms that contain echo and reverb: https://journals.lww.com/thehearingjournal/Pages/articleviewer.aspx?year=2017&issue=03000&article=00008&type=Fulltext...

I have experience with LSD, magic mushrooms, MDMA, and edible cannabis (THC oil) at different doses and they all have different effects on my tinnitus: Micro/low doses: Both LSD and magic mushrooms are variable for me, so when the day of the microdose goes well, I can focus on things other than...

Hi Justin! Have you been in contact with anyone from Frequency Therapeutics? As much as I understand there is competition in biotech markets, hearing loss and tinnitus are a devastating global phenomenon that may be better tackled with a collaborative effort. Sharing research between...

I really hope, my anxiety has been through the roof lately and affecting concentration more than my current difficulties with tinnitus.

How many years could this SARS-CoV-2 pandemic set back research and progress on getting this to market? I hope none of the important researchers and staff get sick and die. That could be massive delays and lost knowledge :(

Development of additional lab space for Frequency Therapeutics! https://www.post-gazette.com/business/healthcare-business/2020/02/25/commercial-lab-space-Pittsburgh-research-Lucchino-Boston-drugs-startup-upmc-university-of-pittsburgh/stories/202002240120

If the improved version of FX-322 (both low and high frequencies) and Hough's treatment could be taken together, that would be killing many birds with one stone!

I have this feeling since the day I woke up with tinnitus after taking Azithromycin. It's been a few years since then and no improvement, and I initially thought it was eustachian tube dysfunction, but I also read high frequency hearing loss can also contribute to fullness. I really don't know...

"Boston area startups making slow progress in fight against hearing loss" https://www.bostonglobe.com/2020/02/02/metro/boston-area-startups-making-slow-progress-fight-against-hearing-loss/ Excerpt:

Not so fast, there are studies that show to be helpful: https://journals.lww.com/thehearingjournal/Pages/articleviewer.aspx?year=2017&issue=03000&article=00008&type=Fulltext https://www.frontiersin.org/articles/10.3389/fpsyg.2014.00587/full...

Why do many doctors say that macrolides including azithromycin are not ototoxic, yet some articles claim they are only temporarily ototoxic? What gives?

In order for the drug to restore lower frequencies, it has to be able to reach further towards the cochlea apex. See my earlier post regarding Otomagnetics delivery system. Theoretically, that system will allow the molecules to go further into the cochlea via continuous magnetic force rather...

That might change in the future once technologies are developed to deliver more efficient payloads directly to the inner ear with less waste and relinquishing the need for puncturing the ear drum. See: https://otomagnetics.net/technology

I also like to eat, drink, be merry, and use earplugs if the pub is too loud ;)

Hi Liam, what is your take on the development of Frequency Therapeutics treatment for hearing loss and the possibility of improvement for certain types of tinnitus in the future? The drug triggers the regeneration of hair cells...

I wonder how long it will take for FX-322 to be available in Canada?

I think it's mostly for preventing data bias: https://en.wikipedia.org/wiki/Bias_(statistics) I would also guess that they want to set boundaries between themselves and patients when it comes to the relationship/psychological aspect of treatment and trials.

It didn't catch my excitement until now for some reason aha, but yeah that's really soon!

https://www.nasdaq.com/articles/degenerative-disease-biotech-frequency-therapeutics-sets-terms-for-$101-million-ipo-2019 More info on the IPO. Anyone else know when it will actually show up as an available stock in regular brokers?

Although there is some debate between clinicians’ experience, both older and newer research suggests that testing frequencies beyond 10kHz may obtain useful information for tinnitus patients who report higher frequency pitches, difficulties with speech in noise, and may be able to reduce the...

Investing ain't a get rich quick scheme: https://www.investopedia.com/investing/dollar-cost-averaging-pays/ I'd like to put smaller amounts of money into companies that I believe in consistently over time, much like any other intelligent investor.

To anyone knowledgeable with investing, when do you predict we will able to buy stock of Frequency Therapeutics?

I do know that the size and structure of the cochlea is such that it probably wouldn't support detecting frequencies above 22 kHz at the very max in the most healthy young person. Unless someone went in there and physically made space for more hairs, or tried implanting additional cells (more...

Technical question: anyone have any insight if cochlear hair cells can only be regenerated a certain amount of times before the therapy loses effectiveness altogether? For example if I suffer NIHL and have it treated with FX-322, then I am exposed to additional NIHL that's out of my control...

Sounds like toxic negativity on your part. I have bad tinnitus as well, but that has no effect on the good scientific work Otomagnetics is doing. They've already received research grants and present at conferences, so it will be a reality in the future.

I hope they team up with Otomagnetics so that they can get the molecules into the inner ear more effectively, rather than just a crude injection with a needle:

Check out the video on how Otomagnetics proposes to get the particles into the inner ear more effectively than with injection: http://otomagnetics.net/