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I have a pair of the Peltor earmuffs as well, they are my preferred "everyday" protection, though they don't offer as much noise reduction as the foam earplugs.

I have wondered about the experience of having the IT injected gel and if that might qualify as an "adverse effect" for some people. I have had multiple IT injections over the past year and they are never fun, but they also aren't that bad. However, I have always gotten prednisone or...

My understanding is that Otonomy believes that their delivery method is superior to something like FX-322. Is there any information released anywhere on how deep into the cochlea they believe that their drugs can be effective? Basically, do we know if there is a lower frequency threshold at...

Seems very unlikely. The part of your cochlea that FX-322 will help is is different and distinct from the part that regulates balance.

I can't really answer your other questions, but I have researched this one so I'll take a stab at answering it. This would obviously rely on what the individual's extended audiograms looked like before being treated with FX-322. If the hearing loss was the result of age - then I believe that...

Thanks for the explanation. That was a very clear and concise way to put it. That isn't the part that I found hard to follow though. (I actually work designing audio equipment so dB's and logarithmic scales aren't the part I was having trouble with). Rereading the post, I think it's just more an...

Sorry to necrobump an old thread but wondering if there is anyone here who is still in the same boat? Been suffering with cochlear migraines (similar to vestibular migraines but mainly affecting hearing rather than balance) for about a year now, and would like to hear of any other people's...

Can you clarify this part? I'd like to understand what you are saying here but I'm confused by how this is worded.

When my ears worked I didn't have tinnitus. Now that they don't - I do. There's lots of examples of improvements to hearing helping to reduce tinnitus, no reason to think this would be different.

I really think any one who is overly worried about the IT injection part of this is blowing it way out of proportion. It does look and seems kind of scary, (I've had it done 6 times now by 3 different doctors) but it is very much just like Jack V describes - a bit of numbing gel on the eardrum...

I'm all for trying anything that might help (assuming it doesn't have more than minor adverse effects) but the underlying causes of high frequency (age related) hearing loss and low frequency hearing loss are so different and distinct, do you really think this has much hope of helping? Either...

The results of the trials showed good results in reducing tinnitus and increased low frequency hearing response in patients with Meniere's Disease. It's not aiming to have the same type of effect that something like FX-322 is, but there are more conditions than just Meniere's that it can...

Thank you both for posting that / informing me of that study.

I certainly think that for the majority of people, restoring hearing will hopefully cure or at least greatly reduce their tinnitus issues/suffering. However, I think it is a bit short sighted to think of these other avenues of treatment as a "dead end", there are a large number of people whose...

Thanks for that info, I'm very interested in SPI-1005. I haven't been diagnosed with Meniere's - but I share a lot of the same symptoms (episodic intense tinnitus, fluctuating hearing loss). The potential connection to viral inflammation is really interesting. Do you have a link where I could...

Unfortunately it's not that massive. Most us have probably never even been able to hear close to 20 kHz (20,000). Certainly not too much past age 16 or so. There really isn't too much information up there anyway. You can probably cut out most sound above about 16 kHz without really noticing...

I have now looked up 2 additional studies that also found that acamprosate seemed to lower tinnitus levels while being relatively safe. Is there something I am missing here? Is there some reason that this isn't being prescribed (even off label)? This is the first I have ever heard of it.

I think I'm (personally) more excited about this than I am FX-322. I'd love to see if I can get in to that 3rd phase trial. (Totally unrelated question, is there a way to direct message other members on here? If so could someone DM me and tell me how to do it. Thanks!)

I hadn't seen anyone post this before, but there is also this journal article that is quite interesting. https://journals.lww.com/thehearingjournal/Fulltext/2018/10000/Cochlear_Migraine__A_Possible_Cause_of_Hearing.3.aspx

Thats interesting. Did she ask how ( or why) the doctor came to that conclusion? Did she have any other symptoms that might have pointed in that direction? I was surprised by the diagnosis at first as well, but I can see (in hindsight) that if you were a doctor and had seen this type of thing in...

I don't know if there are any tests that can give a "positive" diagnosis, and I was skeptical at first but my symptoms have responded well to the medication that the doctor prescribed, and after reading the (little) information I have been able to find about it, I think the diagnosis fits. I...

Thank you for this info. Please update this with your progress and let us know if it goes back to baseline. I hope you are doing better.

As long as you can successfully clear your eustachian tube, I don't think it's a problem. I had a number of intratympanic steroid shots, followed up by hyperbaric oxygen therapy only a few days apart which is a much larger pressure differential, and had no problems. I asked the doctors and the...

I feel for you, pretty much everything in my life for the past 20 years has revolved around music or sound in some manner. Almost exactly a year ago, I played a great show at 1000 seat venue and was finalizing plans to play a few festivals in Europe later that summer (not where I lost my...

I was recently diagnosed with cochlear migraines as a reason for my hearing loss and tinnitus. It is a relatively "new" clinical diagnosis, but based on my experience I think it is probably accurate. Just wondering if anyone else here has had a similar diagnosis?

I have to think that Frequency Therapeutics plans to make it at least semi affordable to the majority of people that are going to want this drug. In all their presentations they make a point to talk about how large the potential patient group is, which leads me to believe that the economic model...

Interesting but probably just coincidental, because we hear frequencies on a logarithmic curve - so for every increase of one octave you double the amount of frequencies in that band. For example 1 kHz to 2 kHz is a 1000 Hz difference, but from 2 kHz to 4 kHz is a 2000 Hz difference etc... I'm...

Is there anyone following the release of this drug that could direct me to any resources that can explain the physical process by which E. hydrops / menieres causes low frequency hearing loss? I have found quite a bit of literature available explaining inner hair cells, outer hair cells...

Oddly enough, noise induced hearing loss doesn't necessarily happen in the frequencies with the most amplitude. It has a lot to do with the mechanics of the ear and how the energy is transferred across mediums, but noise induced hearing loss usually shows up between 3 kHz and 6 kHz. 500 Hz is...

I wasn't the one that looked at the results or ordered the test, but the Dr. who ordered it is a leading specialist involving inner ear disorders, so I assume that he thought it was a good image. I did not (at the time of the MRI) have E. Hydrops. I have almost all of the symptoms of menieres...

You can get an MRI done to look for E Hydrops without having the eardrum perforated. It does take longer than the 8 minutes in the linked study though. I had one done last year. The contrast agent is injected in the arm, and the MRI took about 30 minutes.

It seems very likely. Did you watch the video posted a few pages back, showing the speech in noise tests? It was some pretty impressive gains. I would love to see an audiogram up to 16 kHz or so, my understanding is that based on where they are injecting it, high frequencies will be most...

I understand the frustration behind money going into research like this and NOT towards ACTUAL cures that help. But I think that a lot of you guys are overlooking the fact that studies like this do have value. Quick example - lets say that Neuromod groups people into 3 distinct "buckets" based...

I would assume that there are devices that could help with this. My mother had ablation done on her heart a few years back (to stop atrial fibrillation) and I'm pretty sure the doc wasn't just going freehand. Precision seems like the part that medicine has down pretty well.

fwiw, an MRI with appropriate hearing protection shouldn't be any worse than normal every day sounds sans hearing protection. That being said, I would buy my own earplugs and make sure you understand how to properly use them, and practice a few times at home first. It sounds kind of stupid, but...

I'm not a doctor. But I do like to read lots of literature and try to stay informed about this kind of stuff. My understanding is that there is very little evidence of Prednisone or other steroids being helpful for hearing loss from acoustic trauma. Prednisone is usually prescribed for...

I essentially did the same course this past August. 20 sessions, spread out as 5 sessions per week for 4 weeks. My hearing loss was not from acoustic trauma, but rather from something (likely a virus) that damaged my inner ear/cochlea. I was the patient with "sudden single sided hearing loss"...

Thank you to everyone who commented on this thread. I still feel like I have "lost" some of my previously learned ability to ignore the T, but I feel like I am doing a bit better today, and hearing other peoples experiences (as well as re - realising that I am still only at best 6 months into...

So I have had pretty bad tinnitus in my right ear ever since an unfortunate viral infection earlier this year (May?). A couple of months ago my left ear decided that it wanted in on the act as well, and following a business dinner at a very loud restaurant I ended up with a new very high pitched...

He is isn't he? He's actually pretty normal looking (in real life), just happened to get a good pic of him that day!

When you do an audiogram they will (usually) measure both "in air" hearing and bone conduction. If your "in air" hearing is bad but your bone conduction hearing is ok, then this indicates that the problem lies somewhere between the ear canal and the cochlea, but that the cochlea/inner ear is...

Hearing aids or bone conduction hearing devices should be able to help with both the hearing and tinnitus. As long as your inner ear / cochlea are not damaged, you should be able to get back close to normal hearing via technology. As far as abating tinnitus, your inner ear doesn't really care...

If this is what I am thinking of - they disperse the medicine into a slightly magnetic gel, and then an MRI is used to essentially apply pressure to the gel to get it to disperse in particular directions.

As someone who suffers from hearing loss < 1 kHz, my hope is that targeted drug delivery won't be too far behind a functional drug. If not... I'd be willing to undergo surgical methods (if available) to cram some FX-322 (or something else that works) deep into my apex.