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Good question. Looking at the left figure, I'm assuming the concern is well maybe the first response in the bisensory condition is a fluke since there's no response beyond sham treatment in the group that got sham first. And yes, ideally, I would want to see that. However, the positive spin...

For sure — Anybody can ask the journal for access to the raw data and authors should comply. Though at this point I’m not sure I’d want to bother the authors since they have an important job of commercialization that I’d rather them not get distracted from...

Jeez I didn’t think my response would contribute to such a tussle. I have a PhD in Neuroscience and work in the psychiatric disease drug discovery field so I have a little experience in both writing and reading the preclinical and clinical CNS therapeutic literature. Based on my reading of the...

In reading the paper, a couple of reasons to be optimistic with respect to the worry about “non-responders”: 1. The mean response is not yet plateaued at 6 weeks so presumably with further treatment more people may fall into the “clinically significant” category. 2. I’m assuming that with...