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I’m sorry to find you going through this. I’ve been a long-term sufferer myself since 1992. I got some relief in 1996 from TRT, which helped with the tinnitus but not much with the hyperacusis. In 2016 and 2017, the tinnitus seemed to worsen again, and now it is back to the disturbing level it...

It’s great to have a dedicated scientist here who is close to the cutting edge and can explain things. It seems the problem you’ve raised could be rephrased as follows: “The scientists need to create or design an ex vivo cochlea organoid that matches or closely resembles the human one.” It...

Turning to poetry here, and this is on the topic of discovery. I don’t have a degree in English literature, so this is just my interpretation of some lines by Keats that I remember from high school: “…Or like stout Cortez when with eagle eyes He stared at the Pacific and all his men Looked at...

It will be interesting to follow the research lines of Cilcare with their man-made organoid, as well as the work developed by James Hudspeth (R.I.P.) and the Rockefeller Laboratory of Sensory Neuroscience. https://en.wikipedia.org/wiki/A._James_Hudspeth Researching the same phenomenon from two...

Organoids? Are these like living organs, then? It seems that if so, they’re working in parallel with the Rockefeller University project, where auditory scientists extracted a small section of a gerbil cochlea and kept it alive in an electronic chamber.

I’ll second that! It’s so easy to fall into the trap of thinking, “What kind of juice shop is this anyway? I’ve been waiting here for… {insert number of years you’ve had tinnitus} years! What kind of service is this?” The sad truth is that tinnitus, and hearing loss too, are among the orphans...

Well, I’m the opposite! I have it in my left ear, since 1992 — thirty-three years ago. It’s no longer the awful threat it once was, but the hyperacusis is still a big problem. So I’m waiting for the printout, as listening to TV, a smartphone, or internet speakers will bring on a tinnitus spike...

First living cochlea outside the body shows how hearing really works Some more euphoria for you all. Why am I bringing this up again? Well, I think those first in line for the euphoria are the scientific community, audiologists and researchers in particular. The breakthrough is bound to...

Splendid idea! I can foresee immense savings if, instead of holding a presidential election, they simply flipped a coin. Heads, Trump wins. Tails, the Democratic challenger wins. The United States and the world would be spared all the noise of primaries, backbiting, scams, and all the related...

Oh, what a lovely world! War in Europe, genocide in the Middle East, chaos in America, Japan growing old and gray, and China? Well, we don’t really know.

https://www.csmonitor.com/USA/Education/2025/0825/trump-science-brain-drain-europe Now, I’m not a Christian Scientist, but I do respect the journal they publish. I also recall an article from CNN saying much the same thing—that the Trumpian and Muskian cuts to research and development have...

Well, it’s nice to have someone who can translate things down to my level. I spend a lot of time wondering what caused the latest spike. Most of the time, I would put it down to some noise event. Another plausible explanation is my poor sleep pattern. I can fall asleep pretty easily, but I tend...

While we are awaiting the launch of Dr. Susan Shore’s device, it might help pass the time to speculate on how Rockefeller University will make use of this ex vivo living gerbil cochlea. a) They could test some of the earlier small molecules that were used by Otonomy and Frequency Therapeutics...

Some more Euphoria for all of yous: https://scitechdaily.com/a-masterpiece-for-the-first-time-scientists-keep-a-mammalian-cochlea-alive-outside-the-body/ It’s pretty much the same as in the link that @ploughna gave, but with the details explained more clearly for the layman. It appears that...

@AfroSnowman, and in the same theme, those of us who have been here a while remember how the great excitement about Lenire and then FX-322 melted into crushing disappointment. The message boards leading up to those collapses were filled with a constant buzz of manically optimistic comments and...

Doctor, make me young again. What's that expression they use? "Curb your enthusiasm," or something like that. Thirty years of research, and now after the final dress rehearsal, the premiere night performance has been announced. I can hardly wait for curtain-up time, and I am as fixated as the...

Just curious, is there really no way for people who have completed their treatment with Lenire to put it up on eBay or Amazon and sell it second-hand? Excuse my ignorance. I realize, of course, that you would need an audiologist who is well-versed in Lenire to calculate the necessary...

Do you recall the lively discussion with Tom Cync, who managed to emerge from the depths of tinnitus and hyperacusis by somehow “weathering it out” and trying to get used to loud noise? https://www.tinnitustalk.com/threads/im-fine-%E2%80%94-tinnitus-is-basically-not-a-thing-anymore.55510/...

This looks like a goldmine. For those of us who are not very scientific, the overall picture is beginning to emerge. Very often the source of our tinnitus and hearing loss lies in the cochlea, but it can also reside in the brain, or in both the cochlea and brain together. In the search for a...

I lived in the States around 1989, in Washington, D.C. One of the scariest events I remember was when the gay community held “AIDS Action Week” and spread out a quilt on the Mall behind the White House. It must have covered at least one square kilometer. Each quilt piece had embroidery, a photo...

My deepest sympathies go to the Kirk family, and I want to extend them to all of the United States. Am I a Biden supporter? I suppose I am, or perhaps I was, although I am not American. For me, America has always been that wonderful land of optimism and good humor, where people were open and...

In the case of early-onset tinnitus patients, I can easily understand the difficulty of wrestling with a changed auditory world of constant ringing, twenty-four hours a day, seven days a week. That would naturally involve a psychological factor—the panic of trying to find a therapy or medicine...

Ha! Quite amusing, but it is not enough to go on. By the looks of things, Donald seems to like big blonde women—there’s Ivanka and his previous wife. I must confess that I also find big blonde women attractive, so I cannot cast the first stone. In my view, the real question is: how could Donald...

@Luman, ummm… I think the world is entering a dangerous stage right now, and from various angles. You can pick and choose which one feels the most immediate or the most dangerous. Climate change? The hottest summer on record. I will never be a movie star now, Hollywood has burned out. Security...

Many thanks for taking the time and effort to explain things. It lifts our spirits to have a member who is on top of their game in auditory matters.

Show me the data! And I say that with some embarrassment, as I learned today that Trump is lambasting the Europeans—for what? For buying cheap Russian oil. No surprise there. My guess is it is probably the Hungarians or the Slovakians, since they are often eager to please Putin regardless of...

https://www.irishtimes.com/opinion/2025/09/03/trumps-persistent-idiocy-has-hugely-diminished-americas-standing-in-world-affairs/ Trump's persistent idiocy has hugely diminished America's standing in world affairs US president confuses anxiety and obsequiousness he produces in other world...

Bowled over by your scholarship in this specialized area of medicine. I recall one post from @Nick47, not so far back, I believe from this year, where he mentioned that some form of delivery method, specifically injection, had fallen into disrepute. Was it the intra-tympanic delivery or the...

Image-wise, it looks like Trump has dropped a clanger. He imposes his 50% tariff on India, allegedly because they are buying Russian oil and gas. China then steps in to take up the slack and supports India with a favorable trade deal. Who wins, who loses? I suppose the market will tell. China’s...

View from the back of the class. Well, I guess the study might be useful in its own way. When rejuvenating the hair cells or synapses, it is important to keep the noise level down for a few weeks.

Hey! Is this my birthday, Christmas, or what? I never thought they would arrive in the height of summertime! Before and after my first encounter with tinnitus, I was pretty much in perfect health. That made me believe there must be some simple cause, like a tiny screw loose in my ear that just...

Much appreciation and applause for the time and patient effort devoted to this examination. And no fault with the firm involved. They were quite upfront, but rather expensive.

Duh… can we conclude that Enbrel causes tinnitus, then? I’d say there must have been other factors involved as well. For example, prolonged negative stress, loud noise, infection, or age, which are the usual causes. Or maybe I should be more patient with the pharmaceutical sector, since they...

Well, in France, during August, the whole country goes on vacation?

Interesting point. The drug is targeted at those with blast-induced tinnitus. It seems that army veterans would be the ones most likely to need treatment for this. Florida has no shortage of army bases, so did he advertise properly in the areas near them, as well as in veterans’ hospitals?

Early-onset patients in the acute phase of tinnitus are often driven by the fear that if they don’t cure it quickly, it will become chronic and permanent. But if you’re already a chronic case, I suppose it’s only natural to weigh things up and think, “If there’s a risk of it getting much worse...

I hope that Professor Shore is strong, healthy, and enjoying her retirement. Duh… what was that story about Fermat’s Last Theorem? :unsure:

This looks very promising.

Really good video, but many of us cannot listen to the sound due to Hyperacusis. I wonder if there is a transcript that covers the basics. The subtitles are too small and move too quickly. Maybe I should get a magnifying glass. It is great to hear that something else is on the way. If Auricle...

How I wish I had paid more attention during my statistics course back then. I can clearly recall a unique occasion when human trials were interrupted, and the medication was approved early. That was during the AIDS epidemic, and the reasoning was straightforward. The drug had passed both animal...

To my dismay (or perhaps excited outrage), my summary was not clear enough. The researcher in question was born nearly completely deaf, yet excelled in school and eventually earned a doctorate in biology or physics. His primary interest was the effect of magnetism on cells, and he applied to...

A researcher with hearing loss got a grant to study restoring hearing. The Trump administration canceled it because of DEI Meg Tirrell ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ The heading says it all, really: the struggle over research grants. In this...

I realize that I’m out of my depth here, but if it were possible to place the subject—whether human or animal—under stress while simultaneously observing the rate of cerebral blood flow to specific areas of the brain, could that provide more clarity on the overall picture? It probably would not...

It could be that you are wrong or right. There is no way of telling unless the writer is tracked down. I know of a somewhat amusing true story about a patient whose 24/7/365 tinnitus was accentuated when climaxing with his girlfriend. At least, the “intrusion factor” was intensified by the...

This is a really thorny issue, and I wish the experts could come together and show us the right direction to take. The conventional thinking among therapists is to get used to what they call normal noise. But may I ask, what is normal? The duration of the noise is also important, as is the...

I hate to rain on your parade, but you might be making a judgment too soon. While it’s true that many people learn to habituate to their tinnitus, in my case it only began to improve slightly after one year. Even then, it was still a major bother. I tried Tinnitus Retraining Therapy when it...

This might be a bit obscure, or it might make for good reading. Who knows? The folks at Rinri might even find it useful. It is neat and interesting, but to be honest, I could hardly identify a cell even if it were inside a prison. So I will leave this one to the heavyweights...

It is fascinating if scientists are truly homing in on how tinnitus is generated on the brain side of things. If we combine this with the new methods of scanning the cochlea, perhaps we will finally begin to understand the nature of the beast from both the brain side and the ear side. I have...

Back in the 1990s, when I was younger and had more energy, I tried this therapy myself: a low-level laser directed at my inner ear from behind. It was combined with an injection of Ginkgo biloba (I hope I am spelling that correctly), and I had to breathe in pure or nearly pure oxygen through a...

Well, it is great to hear about some success. Zinc might be something to take when you experience a tinnitus spike, to help you get through the worst of it. It certainly deserves further research.

It is a disgrace for the research community that this is still being discussed and questioned. I suppose they will have to go back to severing hearing nerves just to prove a point—though this time, making sure the data is accurate. Of course, I am not volunteering myself. And how should the...

@StoneInFocus, I must apologize. I let my feelings get the better of me. A wave of gloom came over me when I added everything up and concluded that, whatever promising research is making progress today, it will probably reach the market in ten years—by which time rheumatism or arthritis may have...

Therapies targeting recent-onset cases are where most of the successes seem to cluster. (Mind you, I have submitted my patented cure for recent-onset tinnitus — 100 percent natural — breadcrumbs! But don’t tell anyone. 😎) It makes you wonder about the connection between psychology and...

Go on! Silver-tongued, pseudo-academic, raising our hopes… But if you are actually onto something, that would be wonderful. So, where is the catch? Does it only work for early-onset cases who happen to be billionaires? 😟

Just me surmising again, so perhaps it’s nonsense. Starting with the first ten words of the quote: “The development of an effective therapy for tinnitus and hyperacusis…” First, the patient presents to the ENT with subjective tinnitus. After being checked for earwax blockage and tumors, they...

I read one of the reports from your link, and it provides a good overview of the direction audiology research has been taking. It highlights how the field of knowledge is evolving and emphasizes that there are still significant gaps that need to be filled. For example, one research team might...

Here I am, extrapolating on something I only half understand. But if I recall correctly, Lenire is a combination of sound therapy and a device that “tickles your tongue.” To be a bit fairer, it also involves guided counselling, which in the early stages of tinnitus can be quite important. From...

Nice summary, @trevl, and it matches my experience as well. That said, we still do not know the full story of what is going on. There could be tinnitus, and then there could be tinnitus. What I mean is that the auditory system is incredibly complex. Of course, noise-induced tinnitus is...

Sorry to hear that you are in such a position, @Kam75. It feels like the world has gone mad. Just last summer, my landlord gave me notice to leave after seven and a half years. With the way things are going, it has become very difficult to find a place to rent. It seems like there is a new...

Now all Lenire needs is to introduce an after-sales follow-up, a heavy-duty persuasion session to convince the patient that their tinnitus has been cured. Like, no one can hear it... it is all in the mind. Just kidding. That said, I must confess that I benefited from TRT treatment back in the...