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You all are referencing the work of Dr. Matthew Carlson, with whom I have spoken on a few occasions. Net, net: Dr. Carlson is in Phase 2 trials this year with about 12 people. He then wants to do a third trial at several locations in the USA, including military bases due to the huge veteran...

Hey Bob, Sorry for the late post. I have had Signia Go with notched technology for a year and it hasn't helped my tinnitus at all. In fact, my tinnitus has gotten worse, which I attribute to anxiety and an inability to get used to these intensely annoying noises. What I have liked about the...

In light of OTO-313 not planning out (and that path now possibly in doubt), I hope this path can somehow get expedited.

Thanks! I may just get in under the wire...

Does anyone know if there is an age limit for the potential efficacy of these treatments? I'll be 60 this year, and I keep being told that hearing loss (and tinnitus) is age-related. By the time this product actually is available, commercially, I could be pushing 65. Is that too late???

Hi Danielle, I hope you are doing well. My tinnitus has been quite bothersome, lately, especially since my ears have become very full on both sides. It could be allergies, but a tympanogram found that there is no fluid in my ears and the pressure is normal, so I wonder. I have read that...

Thanks. I'll wait to see if I am accepted and go from there.

True. I also have a big dropoff at 8 kHz, as well.

Thanks. Still not sure whether to participate, or not, if accepted...

Thank you, my friend, for a really inspiring and heart-felt post with some great ideas. I really like the idea of using one word to describe each day on the calendar. I think I will start doing that, myself. Like you, I have good days and bad days. The problem, for me, is that even the good...

That's the one! The question is whether to go through with it, if selected. Is FX-345 so much better that it merits waiting for those trials?? And do we think this will help tinnitus, as well? I only have moderate hearing loss...

Thanks, Scotty---I will check it out. Best of luck, and looking forward to reading your results!

You make a good point, of course. I'm just really struggling, right now, and I'm getting very anxious and depressed about my condition. I guess I just have a hard time seeing myself 'habituate" to this monster...

I'm not sure what to do, at this point. It takes up to eight weeks to determine eligibility, so I will see if they even accept me...

Bruce has four tones in one ear and three in the other. He described them to me and they sounded awful. Somehow, he blocked it out. He may be much stronger than I am. I'm seven months in and for some reason I am really in a tough way, lately.

Same with me. I wonder, though, if it is worth it to participate in the FX-322 trial when FX-345 seems to be much more robust? Is it worth the risk? Will it help with tinnitus? I don't have that much hearing loss, just some at 4-5 kHz.

I did two sessions with Bruce Hubbard. Bruce is rather a "tough love" kind of guy. He doesn't think we impact our tinnitus in any way (supplements, treatments, medications etc), he believes "let tinnitus do what tinnitus will do." His main coping strategy is to write a recovery statement and...

I was most interested in the cochlear implant video. The researcher stated that patients that had asymmetric hearing loss, which I have, showed 80 to 90% improvement in tinnitus due to the implant. I wonder if I am missing something, here, because that seems like a no-brainer, if it is real...

Thanks for such a great episode! Brian Fargo is a really bright and successful guy (look him up on Wikipedia), so it gives me a lot of confidence in this technology that he would make such a substantial donation towards the research. He wouldn't do that if this did not hold enormous potential...

Brilliant!

Yeah, I think my mom told me to turn it down a few times. My band was so loud that an old lady heard us from miles away and called the cops on us. They said if we could play a Clapton tune they'd let it go, so we did a bar or two of "Cocaine" and we were cool. We thought we were so cool...

Same deal, George. I played loud guitar, shot guns, used loud saws and such, and it took until 59 to get the major spike in tinnitus. I'm paying for all that stuff now, but honestly, did anyone really tell us about future hearing loss, back in the day, like they can now? Hearing protection...

Right there with you, brother. I grew up in the 60's and 70's, when ear plugs were primitive, at best---hardly anyone wore them. I had a bunch of times getting blasted from loud amps (often my own) before I bought a pair of Norton Sonic II earplugs, which took off like 8 dB. I wish we had the...

Cool. I've been playing guitar for 50 years. Probably a big reason for my current issues. I had 58 pretty good years, at least...

Good to know, thanks. May I ask your age? I'm 59. I just did a session with Dr. Bruce Hubbard and he thinks tinnitus is really a factor of age and loud sounds, if you are a musician (as I am... or was, anyway...).

Did you taper off of the drug? If so, what was your schedule (how many weeks, and how much, per week)? I am tapering really slowly from Amitriptyline... I actually use a jewelry scale and go down little by little each week. I seem to be very sensitive to these medications...

It really is a Sophie's Choice, frankly. I need to sleep, and nothing knocks me out like amitriptyline. However, the extra tinnitus in my right ear, the ear fullness, and the louder volume is freaking me out, so I think I just need to get off it. It is ironic that the types of medications that...

I was on Amitriptyline for nearly 25 years and it was fine----slept like a teenager. Then I got this huge tinnitus spike (likely from the Moderna COVID-19 booster) in November. I was having trouble sleeping, so I went back on the Amitriptyline. Maybe I'm just a loopy Boomer (59), but I feel...

Dr. Grundfast is a nice guy and spends a fair amount of time with each patient, which is great. But no one has any answers, it seems, so yes habituation is the end goal.

Hi Danielle! I have seen Noah Siegel and Kenneth Grundfast. Nice gentlemen, but no solutions, of course...

New Hampshire, here! I really hope their research is successful.

If not mistaken, that other trial involves MRIs to look at how the Lidocaine affects the brain. You also can't be on any ADs, either.

Glad it is working for you, Ben!

I actually had a bad experience with Paxil, which I am told is a lot like Trazodone, so I was advised against it. It also gave my fiancee a massive headache. Thanks for your input, though!

I have heard of Seroquel. Any side effects? How long have you been on it, and what dosage, if I may ask? Thanks.

I try to stay off of the benzos as much as possible. Lorazepam still does the trick, though today I woke up with the worst tinnitus ever, and it scared the daylights out of me. I may have no choice but to push for Klonopin, if things keep getting worse. As for Amitriptyline, I can't figure out...

I have looked into both, yes. Lorazepam has a half life of about 12 hours, so it is out of your body in about 3.5 days. This is why it is so good for sleep; one pill lasts for about 6-8 hours, then it's gone, so you don't feel groggy, the next day. Klonopin has a half life of 20-50 hours, so it...

I take Lorazepam on a regular basis, for the simple reason that it is the only reliable drug that can get me to sleep and I am guaranteed to have a low tinnitus day, the next day. I'm very careful not to abuse it, however. Lorazepam has a very short half-life, so it is totally out of your body...

I actually applied for this trial, but was denied, due to the fact that my scores on the questionnaires were too high, indicating I was too affected by my tinnitus. Jenna is a terrific person, and has tinnitus, herself. She was a terrific resource for me in directing me to other people who can...

This sounds interesting. How long would it take to get this to market, in your opinion? If it's successfully marketed in the EU, I wonder how long the FDA would drag their feet on getting this approved in the States...

I think Neuromod is grasping at straws. I spoke with an audiologist in Boston who was going to do a trial of Lenire with 10 patients, this winter, and right before the trial was supposed to start, Neuromod canceled it. I got the vibe from him that the device is "not ready for prime time," so to...

I guess I see a bit of a disconnect, here. There almost seem to be two paths: academia and commerce. On the one hand, I know that Dr. Shore needs to build credibility for her product in the academic circles, hence the research and rigorous review via journals and publications. On the other...

Hey Ben, Does this app come in an Android version?

Fingers crossed, my friend! They need to do so, and fast. Their cash burn is $43 million per year, which means they will run out of money by Q2 2023, assuming they don't raise another round of funding...

Thanks, Diesel, very informative. My tinnitus has been at about a 2 for a very long time. If I can just get it back to that level, or even a 3 or 4 I'd be feeling a lot better. Of course, those of us affected by COVID-19 or a COVID-19 vaccine will be out of luck by the time this med gets...

It seems early 2023 is important to several of these companies. Otonomy has enough cash to get until the spring of '23, for example. These companies need to show consistent results, and soon. I'm pulling for all of them.

My question is simply what does one year mean? I probably have had tinnitus for close to 40 years, but at a very low level. The Moderna COVID-19 booster sent my tinnitus into the stratosphere. That was 4 months ago. So do they consider my having had it for 40 years? 4 months? These are questions...

Impressive results, indeed. I wonder, however, if the fact that all of these tinnitus patients in the study had had tinnitus less than one year might have impacted their TFI results? For those who have had it for quite some time, there has been some habituation, typically, so might that impact...

Ben, 110 percent. I know that we have to accept the condition in order to help the process of habituation. I guess we just have to stop listening to it so much, which is really difficult, especially in my case, as my tinnitus has become very difficult to mask. I think the big thing is just to...

Thanks for the good wishes, Ben! Lately, I have noticed my tinnitus becoming more high-pitched and consistent (could be the Amitriptyline?). So it's harder to mask. Has your tinnitus fluctuated at all, or been relatively consistent?

Hey Ben, Sorry to not reply sooner. I have had the hearing aids now for about 7 weeks. The notch concept of making the tinnitus sorry of fade into the background has not worked for me, so far. I think this is mainly because I can hear several different tones, depending on the day. I will say...

Thanks so much for you input, Roy! What dose of Gabapentin do you take? My psychiatrist prescribed 300 mg twice a day, or 600 mg per day, total. Also, when you say Gabapentin has affected you cognitively, is it primarily memory recall? I find that with Amitriptyline---it makes me duller. I...

Great post, Roy, thanks! How long were you on Amitriptyline? I've been on it for 6 weeks, and last week my tinnitus spiked. So I was just prescribed Gabapentin to try to chill out and for sleep. It's odd that Amitriptyline isn't working for me because I previously took it for 24 years for...

Interesting experience with Amitriptyline, DoesItStop. I'll share my experience with the drug. I have had chronic fatigue syndrome for 32 years (I'm 59), and for most of that time, my CFS was in remission. I also have had very low level tinnitus, I would say it was about a one or two on a...

I saw two ENTs in Boston, recently, and one of them said he could get me into the study. At the current time, I'm not really interested in doing the study due to a) Lidocaine being only temporary and b) I loathe MRIs. Of course, I'm at the 3-month point with my tinnitus spike, so if I get...