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Thank you for clarifying this for the discussion. It always amazes me how people read into things ‘what they want’ when all that matters is facts. Of course, we all hope that increased duration will lead to better results, but this is, of course, positive speculation.

You cannot say it’s physiological without an objective measure I’m afraid, and there isn’t one.

Who are you talking about?

You can find studies on all the previous treatments that have had positive results. However, these never translated to real-world experiences. There is nothing wrong with positivity, but there is also nothing wrong with healthy cautiousness.

Anything to look forward to now apart from Susan shores device? Any biotechs, etc T is piercing again.

Thanks to all those who responded to my question. It all looks too familiar with other studies' results (I know they had a control group on this one), which materialized in disappointment in ‘real world’ cases. It always seems to be around 60% of respondents and slightly higher than placebo (I...

I was on the Lenire study like a hawk. However, I am a bit behind with the latest study with Dr. Shore. Apologies if this has been answered before. I have just been reading through the second trial results, which look ‘too good to be true. ' However, what was the percentage of responders out of...

With biotechs, the odds are stacked against you. 1/10 drugs are successful across the industry as a whole, but it’s even wider with more complex drugs (an example would be Alzheimer’s drugs). The thing that got me with Frequency Therapeutics was the comment made, I think by Christopher Loose...

The Susan Shore thread has been active for 10 years… the product (end result) will be out soon…

Sure, if I had money to throw away. I never went for Lenire. But I followed them from the start when it was called MuteButton. It was exciting but it wasn’t the great success it was speculated to be. Personally, it makes much more sense to wait for Dr Shore’s device but, even then, I will be...

There’s a difference between being pessimistic and showing a healthy amount of skepticism. Dr. Shore admitted herself in one of her videos that there is a strong placebo effect in tinnitus trials, along with tinnitus being subjective and having no objective measure of it. I will also add, even...

What I don’t understand from Dr. Shore’s work is this (I know we are still waiting for the results from the Phase 2): Lenire showed similar results but it did not translate to the real world going by Tinnitus Talk user experiences. I know Dr. Shore is using a control group unlike Lenire...

Mirtazapine is not an SNRI - are you thinking of Venlafaxine? This Dr. De Ridder guy is again chatting bollocks.

Head tinnitus doesn’t seem to be there, all the noise in the ear. But in the past when the noise in ear goes down, head t cranks up, ne1 els

When Susan shore says there is a 75% decrease in her patients, is she talking about 1 or all 300 (that was how many ppl were recruited)?

Can anybody give me a brief summary where the biotechs are heading next with hair cell regeneration? I lost money on the first FREQ failure and did not buy in a second time. I have followed tinnitus research loosely for 10+ years and have seen the massive increase in research, although it’s not...

This may seem rather bizarre, but a couple of years ago, I fell in love. My tinnitus went extremely low. I could not hear it. It was like that for about 2 months. It returned to baseline when my relationship developed and the day to day reality set in. It’s not because I was actively not...

Eli Lily bought Akouous today.

Sorry guys - saw the bad news today. Just got to look at other areas now. Seems quite a few of us were not that hopeful with OTO-313. Dr. Susan Shore is the one to watch in my opinion.

Thank you Brian Fargo on behalf of every single one of us.

What's this auricle device and why am I finding out about it now? Has deridder got 1 out too?

Anybody know or have a link to the presentation made today?

These results look like very familiar with the TinniTool I bought years ago for £300. It had a little leaflet with it off this small Italian study showing the efficacy of it. Just like Lenire. Just like ACRN. Not impressed by the slightest. Neither is the stock market. I've followed research...

Otitis externa again!

So the hype builds... again. Can't get an erection just yet. I'm so used to tinnitus research failures that it's part of my life now. Wish them the best of luck though and all the riches in the world if they've cracked at least part of the puzzle.

She does and that is her theory. Regarding Trobalt that is unrelated to her theory, Trobalt was a serendipitous discovery that it helped tinnitus; Dr. Shore is working in bimodal neuromodulation around her theory. I never read much about Trobalt, but it has something to do with potassium...

It happens, random anecdotes on the internet. Who knows why this is. I could spend all day on my own theories and theories of Dr. Shore and Prof. Rauschecker. The truth is; they don't really know.

Took.ibrofon now I have t in my non t ear. Hopefully its temporary.

Buying stock in this is like playing Russian roulette. It is not investing, it's a gamble. Although I'm pleased for your success, I think I can conclude that even if you got the real drug, I can not write this off as it definitely working. Tinnitus can and does subside, although the longer...

If you don't believe tinnitus settles in the brain, watch Josef Rauschecker at his TED Talk to understand why this is a good theory. This is one of the reasons why tinnitus is so difficult to treat. Don't underestimate the complexity of it. If OTO-313 fails, which it likely will, I would...

That's one hell of an assumption you made there.

It was getting lower before the drug though? Fluctuations were normal in your case?

There won't be any tinnitus data though?

Ear irrigated. Always anxious around it. But 2 chunks of wax straight out. Improves the masking at least. Hope everyone is okay!

You are very much appreciated @Hazel and I thank you and the other guys who do the work. I've only had a chance to skim over it but I will tune in for a proper listen. I'm starting to think avenues affecting the brain may be the way to go for a treatment for tinnitus. We will see how these...

A bit devastating when they talk about OTO-313 and chronic tinnitus becoming central, as opposed to peripheral. Wasn't this what Rauschecker was talking about? I would also have liked to hear their thoughts about OTO-413 and hearing regeneration resolving tinnitus. Nevertheless, thank you...

I've seen a few comments about FX-322 not being effective for age-related hearing loss - but these results haven't been released yet? Or am I missing something?

What's everybody excited about? Since fx322 is not looking so good (in the near term)

Buying biotech stock is supporting research. Without the investors on board taking the huge risks, research wouldn't advance and clinical trials wouldn't happen. Biotechs have a high failure rate. I do both. So do many members here who hold stock and contribute to this community. The members...

Anecdotes. If they were given sugar pills, with tinnitus, there would be anecdotes.

Did they ever get their results peer reviewed? I don't think they did. Total failure.

I don't know if anybody feels the same, but I think FX-322 is the end of the line. The evidence against this not working is substantial. I've lost all hope in FX-322 and I get the impression many people were depending on this and they don't want to let it go. I think the next thing we have...

How ironic would it be if Auris took off and solved everything

Miserable fx322 :-(

They all say that. Auris Medical said the same thing.

1000% agree. The reality is that it doesn't really increase WR scores. I questioned this a few months ago when their Phase 1b was released. The company is worthless (at this moment in time). It's time for us to let go off Frequency Therapeutics and the whole PCA for hearing loss and move...

Still need information about: Extended hearing loss frequencies Tinnitus First of I'm gutted for the patients like myself who very much wanted a solution to their tinnitus. I lost nearly all of my savings. I knew the risks.

I thought you were "taking a break" until readout of Phase 2A. You just can't help yourself, can you Diesel....

What do all these things like hall of fame mean next to members name?

Frequency Therapeutics had their initial results peer reviewed. Also, Frequency Therapeutics have been very honest (it's a matter of law) to investors who all have access to their information. Strict criteria are normal for biotechs. They're also doing a separate part of the trial for...

He/she is good!

You don't sound like an expert to me. Just a trolling moron.

Any chance we could get the Phase 2 90-day readout results this evening, post market? They're not going to release the Phase 2 results during market hours, are they? It won't cure total deafness as they're many different causes... but what about noise-induced hearing loss and age-related...

What are the chances of pre market readout p2 for freq tomorrow before presentation?

@patorjk, shorts have lost millions on Tesla (so far). I read an article on the guy who predicted the 2008 financial crash predicting that Tesla will crash and for the investors to "enjoy it while it lasts". The price compared to their P/E ratio is ridiculous! It'll be interesting to see...