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There seems to be two Lidocaine derivatives that could be taken orally. Mexiletine and Tocainide. Both have been trailed heavily in the 80s and 90s with rather good results but due to the effect being only temporary it was not worth the risk as these drugs can not be taken long term. I guess...

Could this be why Lidocaine works for tinnitus but nobody knows why? Almost all papers admit significant reduction or total resolution of tinnitus under IV Lidocaine but can not attribute it to its most well known MoA on sodium channels since other sodium channel blockers do not work. Lidocaine...

Study completed, no results posted yet.

I read about Ivabradine, seems like it's a very serious medication that controls the heart pacemaker current. I do not suggest anybody to try it. It needs medical supervision due to the risk of atrial fibrillation. Also, it seems that this paper in 2015 mentions that HCN2 along with KCNQ...

There was another trial done by another group trying the same protocol by Dr. Shore, please refer to this paper. They mentioned that "When multiple tinnitus sounds were perceived, it was suggested to concentrate on the most troublesome tinnitus sound." Although this trial's results are a bit...

Yes, the device plays the exact frequency that could be matched to your tinnitus. Please refer to this paper. However, please note that they cannot 'match' the frequency in animal model of tinnitus accurately either so if you can match it closely enough, you should be fine.

I had difficulty with matching my tone too. On some days I can easily match it to 10 kHz, other times to 8.5 kHz. I will tell you what worked for me. Go to the most silent place you can go, it could be a closed room in your house with all sound/machines turned down and away from windows or...

Sorry pal, I missed your comment. No, Abilify did not cure me, it just made things better. After 1 week of taking it things were considerably better on all measures. Now, things are not as good as they were after starting the treatment.

I do not have hearing loss. My tinnitus was brought on with Zyntabac as the subject suggests.

I have been prescribed Deanxit + Clonazepam before the Abilify. They did nothing for me. I take the Abilify in the morning. Effects are not as strong as in the beginning but I am still doing better than before it and so I continue to take it. I have more good days now than bad days which are...

Hello bro, I did for 12 days. No change.

8.5 Months Update: I will keep this as short as possible, I have been trying Abilify at 2 mg per day for almost 3 weeks. After just 1 week my distress about tinnitus almost vanished and my tinnitus also dropped considerably. This drug knocked it out by no less than 50% at this time. I will...

Hello Nick, I had positive experience with Clonazepam 0.125 mg + Gabapentin 300 mg per day. I tried this for a short period, like 5 days, and it works. I was tempted to try the Deanxit + Clonazepam combo prescribed to me so I stopped the Gabapentin and switched to Deanxit. I upped my Clonazepam...

6 Months Update: I had a few better weeks followed by a bad week that I am currently experiencing. As of today, my symptoms are not much better than when things started (15% improvement?). I noticed earlier that my neck and shoulder pain became worse which made me go to an orthopedic. He...

I stopped after trying for a month. The tinnitus got louder first, then returned to base level in week 2. It made me much better for sure psychologically by week 3 and I did not care about the tinnitus as much but the tinnitus loudness stayed around the same so it was not worth the risk. I did...

5 Months: Ok so unfortunately, Sulpiride + Hydroxyzine did not offer much help as far as I can tell. It made me care less about the tinnitus but it did not improve the tinnitus itself. The first week I felt things were worse but it stabilized back to the original level. I took 50 mg x2...

Got 3 shots of 50 mg CocarboxyIase (TPP). No effect.

There is also another Thiamine derivative that is more commonly available, called "Sulbutiamine" which is sold under the brand name "Arcalion". Did anyone try it for tinnitus? I found TPP cheaply available in pharmacies too, the generic name of the compound is Cocarboxylase so you may search...

I tried this for 2 weeks. No help.

It is dopamine antagonist, like antipsychotics.

But please note that I got tinnitus as a side effect from a medication "Wellbutrin" and it was instant after just 1 pill. I doubt my "hidden" hearing loss is related to my tinnitus.

No, I have normal hearing up to 8 kHz. I think I have some "mild" hearing loss in my bad ear above this region though when compared to my good ear when I do a home test.

Sorry pal, I don't think Cerebrolysin was significantly beneficial in my case. It did something by the way, but it was not significantly positive. The physical electrical feeling associated with my tinnitus went down somewhat but the volume not so much (maybe a tiny bit). I felt I was having...

Hello @Matchbox, sorry for the late reply. I missed your comment. Wellbutrin does not work on the serotonin. It is a dopamine and norephedrine reuptake inhibitor. At first I was not sure if it was nerve damage or something else and I was put on steroids to avoid losing precious time at the early...

I added 15 mg Hydroxyzine every 12 hours too. I currently take the full stack but on a lower dosage Sulpiride (100 mg) + Hydroxyzine (30 mg) + Melatonin (3 mg). I will titrate the Hydroxyzine to 50 mg over the next few days but will keep the Sulpiride at 100 mg. To be honest, I feel it is...

I am currently experimenting with Sulpiride (50 mg every 12 hours) + Melatonin (3 mg every 24 hours). I have a Hydroxyzine box waiting too but I am not sure if I will add that to the cocktail. Still on day 2.

3 Months Update: Unfortunately, no improvements since my last post. After my last post I started Piracetam, Ginkgo, Vinpocetine and Cerebrolysin. Nothing gave any remarkable improvement so far. I stopped the Cerebrolysin and Piracetam. I will experience with Naltrexone in the next few days but...

I received a reply from the researcher:

Donepezil is used to treat confusion (dementia) related to Alzheimer's disease. It prevents an enzyme called acetylcholinesterase from breaking down acetylcholine. This means there is a higher concentration of acetylcholine in the brain, which leads to better communication between nerve cells...

First week, 5 ML everyday. After the first week I started taking 5 ML every other day. How is it going for you?

Today I have completed my 21 day course. Nothing significant to report. Could be slightly better but hard to tell.

What exactly are his instructions regarding fasting?

I am already on Piracetam, Vinpocetine and Ginkgo Biloba. Will see what benefits Pentoxifylline could add.

I personally do not have hearing loss so I can hear the test pretty well. I found this post about Cerebrolysin pretty informative: https://www.leoandlongevity.com/post/cerebrolysin So far I am on my 3rd dose. Nothing significant yet.

Same thought came to me. I just came back from the dentist and he used heavy drilling. 15 minutes at least. Last time I went (2 weeks ago) I spent the following week with a horrible spike. Today, nothing. Maybe even better than the normal.

5 injections per day must be painful. Good luck. Also, try to listen to some sound therapy after the injections. That's how I will do it hoping that the drug will be more efficient in connecting neurons related to the auditory pathways. When they give this drug to stroke patients who have motor...

I hope you find some positive results. Do you use it through IV infusion?

I am in Egypt. I will let you know how it went after 3 weeks.

Just wanted to make dosage clearer, only the 5ml ampoule should be given IM. 10ml ampoules should only be given IV injection. Anything more than 10ml you will need to use IV infusion.

Cerebrolysin (developmental code name FPF-1070) is a mixture of enzymatically treated peptides derived from pig brain whose constituents can include brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), and ciliary neurotrophic...

Does Naltrexone activate NMDA receptors? I am asking as, based on your suggestions, it seems that it has a counter effect to Ketamine.

1.5 Months update: TLDR, 15% improvement. Tone is softer and volume is reduced. Shortly after my last post, I tried Carbamazepine (Tegretol) for 5 days which made things much worse and I made the decision to stop trying any medication regardless of the recommendations of any doctor. A few...

I wanted to share with you a somewhat nice trick. My tinnitus is at 10.5 kHz, so it is beyond the 10 kHz range for this to work properly for the reason that the highest tone would be 14,674 kHz. That is generally too high and the tone would suffer a lot of attenuation to be heard in comparison...

So nobody got any positive results from Cilantro extract?

Hey pal, Thank you, I read your story and was inspired by it as well. I am curious to know how are you feeling now? I will for sure keep this thread updated for others if I find progress or any medicine to be working. I am currently taking: Cinnarizine 25 mg x 2 (gives me headache, so I also...

Should I try Tinnitus Mix with these headphones, Audio-Technica ATH-M50? Says they go up to 28 kHz.

3 Weeks Update: I decided to try both HBOT and intratympanic steroids injection in my left ear after finding an ENT who would do it. He was very honest with me and told me that after almost 3 weeks the probability of steroids helping is relatively low, he said it could be 25% so it is a shot in...

@BrysonKingMe, wishing you all the best, brave man.

2 Weeks Update: Things are worse, ringing is back in the right ear as well, and left ear is ringing much higher. I can't sleep unless I take some Alprazolam. I am trying to take it only when I need it, it helps me sleep but the screaming comes back soon after it wears off with vengeance. I...

@T_Almost_Gone, how are you feeling this month? Hope you are on your way to be tinnitus free. My story is very similar to you with only 5 days on 150 mg for smoke cessation. I have no history with antidepressants or tinnitus before that. Your post gave me some hope it will get better.

Glad you found some relief! Let us know how it went for you on the next night.

So, some good news and some bad ones. The tinnitus is now almost gone in the right ear, but it is higher in the left ear than when it started. The left ear volume fluctuates between 3 levels, let's say a low one, 2/10, a medium one 4/10 and an extremely unbearable 8/10 throughout the day. I...

@Wellbutrin_Case, would love to know how are you doing now?

A quick update, I started feeling some pressure in my ears with no reduction in the tinnitus so I went to an audiologist today to get my hearing tested after telling him the story. He looked up the Bupropion online while I was there so probably he didn't know that it could be a side effect of...

@Rockman, I hope so, I don't feel any improvments yet but too soon to tell. @CC_16, I did not have severe depression.

So the story begins with this drug for smoke cessation. I previously used Varenicline and successfully quit a few years ago but since it became unavailable where I live, I was recommended Zyntabac (Bupropion) as an alternative to try. Being desperate with no possible ways to obtain Varenicline...