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That's probably the same or similar technique described in the video below; which i believe is one of the most promising cures.

Hello there, Yesterday (25th Sept 2015) was my first anniversary of the dumbest thing i've done in my life. Went to a rock concert in an indoor venue, exposed myself to a so-called music ( that i do not like ) which was extremely loud for more than 2 hours and voila, ringing in my ears. I was...

Dude, don't listen to loud sounds. You seem to have killed a lot of hair cells and/or nerve endings already to cause the T. Listening to loud music/sounds might easily add more to what you have. Take care.

I never got these metrics from audiologist but i'm planning to in my next control visit. Even though it's completely subjective, my T is slightly weaker than before, however the annoyance is way down. For the last two days, there's been an additional drop in the T loudness. Even though it was...

Hi folks, Noticed that i was away from TT long time. So let me give an update on my AM101 experience do far. It's been 1.5 months since the first open label round. In the last control visit 1 month ago, the audiologist noticed there's a sight drop (~5db) in my hearing in both ears. But this is...

Hi folks, Let me give an update 10 days after the last injection. T went back to pre-injections level 2-3 days ago. Bad thing is, i still have occasional spikes and at this point feel like it's very unlikely for me to have an improvement due to AM101. It's been 6 months since onset and the T...

Well my friend @AlexSongitus, i'm very glad that you're experiencing silence again. This is great news, enjoy it while you have it. The only suggestion from me would be, do not obsess about it, because you'll still have some relatively bad days. Slowly stop gauging the T and do not let these...

I believe quite the opposite. They have enough data right now and as a cost cutting measure they're slowly terminating the trials. In US, they're stopping accepting new patients, in EU they're limiting the already existing 3 rounds to just one (not agreeing with your and other's comments though...

My popping in the ears went away only 1 week before 2nd injections, you're lucky dude. :)

Seems pretty much normal. In my first round, the T spike lasted ~3 weeks, gradually resolving after 2 weeks. If this spike does not fade away in 2-3 weeks, it's the time you should be concerned. But, do not worry, it'll go away, there's no reason not to.

Yes they do, after the 1st injections.

Hi Michael, here's my two cents. My tinnitus disappeared 2 times after onset (T0); 1st disappearance : T0 + 1 week, gradually disappeared in 1 week. 1st comeback : T0 + 3 weeks, in one morning i found a slightly different T in the morning. 2nd disappearance : T0 + 4 weeks, gradually...

I'm telling you guys, it's contagious. I noticed this when i read a story about a guy who developed T just by learning some of his friends had it. The guy started listening to understand whether he had ringing before sleep, obsessed about it and voila, developed T. After i developed T, this was...

Let's not forget SF0034. It has my biggest expectation from current research so far.

I periodically meet in a support group with a guy who has T since 1970's. His resolve, patience and strength is amazing me every time i see him. We're just lucky, compared to all these guys, as i believe there'll be a cure in 10 years.

AM101 Update: The flight back home was terrible, the gel drained like crazy. My ears were like a teapot, constantly whistling and spitting gel during the ascent. During the descent the pain became so unbearable that i had to take two ibuprofen pills at once to take the edge off. It worked like...

I bet they will dude. They'll look at this shitload of comments and laugh, especially to your words here :)

@matt89, thanks dude. Yeah, i started to think like this as well. If a gel injection in the ear can spike my T like this, it should mean that the transition to brain is not complete yet. Good news. I had that temporary spike in the closed-label round but the spike that time was nothing...

Shit, this is a completely new territory for me, the loudness should be around 9!!! right now. I can't describe this otherwise, it's almost the same as the night of my onset. Plugging the ears does not change anything. Hope it'll be better in the morning.

I believe that AM101 shall be a huge success and getting that substance into your ears while you can is the best thing one T sufferer can do. Good luck dude.

I have no known sensorineuronal hearing loss below 8k. This drop should be because of the gel inside the middle ear and is supposed to fade away in weeks as the gel drains out. Almost the same thing happened in the TACTT2 trial, except the loss was less back than.

AM101 Update: Wednesday: Pre 3rd Injection T Level: 5-6. Woke up with no pain, thanks to ibuprofen i guess, and T around 5-6. It's audible no matter what you do. Went to site, had the hearing test as usual and surprise, have a hearing loss about 40db on my left ear. The bone conductivity test...

I've been told the same here in LA site. They will not accept any more patients for TACTT2. But AMPACT is still going on and anyone can go for all the three rounds. The doctor does not really say much about the T. Don't blame them, they do not know much. After the 2nd injections, I feel like...

What a nice idea this is. I wish that turns true. Regardless, I'm good by the way. Not stressed, not having anxiety, just balanced. Believing that someday something will come up and relieve us from this annoyance.

AM101 Update Pre 1st Injection T Level: 3, barely noticeable during the day. Monday: I went to the site to continue with open label injections. All my vitals are checked, signed 20 pages of documents, had the regular battery of hearing tests. My hearing was normal, no hearing loss according to...

An audiologist shall give you a much better advise if you want numbers but; when loudness level is too high, i feel the my T goes up (still) racing with the external sounds. I recently had this when i went to a movie theater. I had earplugs + earmuffs, so probably the net db was 30db less than...

Good thing that you're protecting yourself well enough it seems. Where do i draw the line, it depends. I cannot say that i'm OK until 70db but start protecting my ears after 80db. This is all relative and pretty much aligns with the Loudness Discomfort Level of the individual (LDL). Around 2...

I would not take the risk of exposing yourself to high db's, no way. At least until you can safely say that the T is stable already, not reacting much to ext. sounds. I got my T from an indoor f.cking concert and there's no way I'll go to such an environment for years. The damage accumulates do...

Hi folks, I'm in Ampact right now and the injections shall start soon. I'll update how it goes.

Turkey was on the list previously and i know a guy who enlisted. It's been taken out of the list later though, probably they've reached the necessary numbers. There are more and more signs that the trial is coming to an end.

I also agree that the whole system of capturing the max loudness/annoyance is misleading. The average and deviation information is lost in the process. This in turn, as you stated, will cause the results to be worse than it actually is. Maybe this was the whole point, the reasoning was; if the...

I hope I'm wrong of course but there's no known reason that it should work in long term. Esketamine will prevent glutamate storm yes but will quickly be thrown out of the system. I have serious doubts of any improvements because of esketamine happening months after injections. It should be...

Thanks for the info. Honestly i was expecting more or less the same thing. Esketamine in theory should only be effective shortly after onset. I'll be in the open label round next week (5.5 months after onset) and had already decided to not go for the other round. The more time passed after onset...

This is exactly what i experienced and which freaked me out in the beginning. I was masking in the first month while trying to sleep but one day i noticed that the more i masked louder the T. I just felt very afraid as i realized that i had to listen to this shit and there's no way out. This is...

This is so important, acceptance. When you make peace with this enemy of yours, it becomes so easier to deal with. And yes it's our only chance other than waiting for some treatments, fighting does not help as this is a fight you cannot win. I've past this stage too, in peace with this condition...

3 months after i was subjected to acoustic trauma.

I believe this drug is not that much effective unless it's administered very soon after onset. Yes you'll probably get some improvements (like i did) or it'll push the tone of the ringing to a higher pitch if you get it months after onset but that's about it. However if you get it very soon...

This is just a theory but i believe it's mostly true even though it seems little bit mystique. It's all about your brain loosing trust to you. After the incident (if the t is caused by a trauma), brain reacts to this damage in your cochlea and a series of things happen; 1. Lack of signal or...

Yes i'm better, definitely. Even though because of the nature of the double blinded study there's no certain way to say that this is due to the injections or natural healing (The reasons or mechanisms of this healing is unknown but i have a theory.) that may happen after onset, i believe it's...

There's one here who got significant relief after 2nd open label round, around 8th month. Just don't remember the name.

In my understanding, this drug is incredibly effective very shortly after onset. I mean, if administered days after onset, it just kills the T. This is what they've found in rodents (by chance though). And as the inner workings of mice ear (cochlea, hair cells, nerve fibers, the chemical...

Yes, the damage can come not only from an exposure to a short but very loud sound, but also to exposure to moderate loudness in long time. They both benefit from the drug as far as i understand. There's the natural recovery + habituation going back shortly after onset of T and if there were no...

Lovely baby, it'll get much better for you. Don't stop ignoring the T. :)

Side affects of the perforation of the eardrum IMO. I had a similar issue, but my eardrums were more stiff than usual. I'll see whether it went away or not next month. Do not worry that much.

I noticed a change in tone after the injections but, it's probably the lower pitched right tone became quieter thus the high pitched left one became more noticeable. But in general i'd attribute significant changes in tone/loudness to esketamine.

Yes you should, do not miss this unique chance.

Hi Nick. When you loose some hair cells or lose some connection bw nerves and cells, you can still hear fine and your all tests may show that you have perfect hearing. You cannot jump into the conclusion that if these tests show no hearing loss, then i have no hearing loss. (In my case my...

The injections may cause conductive hearing loss which is temporary as the middle ear is filled with gel and does not conduct the vibrations from ear drum to the inner ear. When the gel clears, it's gone. One way to check whether the hearing loss is conductive or not is to have a bone...

This is not quite right. Tinnitus can be caused by any of the issues along the pathway from eardrum to auditory system. For the inner ear part, Sensoryneural hearing loss happens because of either death of sensory cells or nerve cell damage/disconnection from sensory cells. We have...

Ask your doctor about what you should do. My doctor told me that even water goes in through the hole and u get an infection, curing it would be very easy. So contact them asap.

I do not see any correlation bw T&H and memory functions. Not remembering thing might be related to your stress and anxiety. You're probably thinking that not remembering things well is causing your anxiety. I believe the opposite, you developed anxiety, this caused decline in a lot of brain...

Probably due to the plastic nature of the brain, you'll habituate to these new information which makes you uncomfortable right now and get used to them. In the mean time, your brain shall learn to perform better amplification. So do not lose hope. We'll all get better.

You know what, i have a similar feeling towards music. I do not want to listen to music that much anymore. I enjoy quality music still but the fear of it causing a spike is killing my motivation as still my T is highly reactive. Your condition though, sounds to me like you've lost a good deal...

Indoor rock concert. My T is mild-moderate i guess, at least i'm not freaked out anymore, no depression, very very little anxiety, moderate annoyance. The T is tending on the mild side after my AM101 injections. The frequencies are 6-7Khz on the right and >10Khz on the left. H is only present...

Probably you're referring Potassium Channel Modulator's. The brain tries to compensate the loss of input from cochlea by amplifying the inputs, thus causing T as we all know and the article states. This amplification is done by the neurons, actually by hard working and overly excited neurons...

They already know that esketamine works, they don't know as much for long after the onset it works to a reasonable degree. I remember the report about the time the drug is found to be effective on rats and it completely (100%) eliminated the T on them if administered very soon after noise...

It's too early still and if you've had your AM101 injections in 6 weeks (which is awesome), you're guaranteed that you'll have the real drug around 4 months, which'll probably give you a significant permanent relief. You'll get much better even if you're given placebo in the first round. First...

Yes, as AM101 is the only viable option that we have to get a permanent relief during acute phase. If it means being annoying, so be it.

No, at first i applied to Portland but got a reply saying that they just stopped accepting subjects so applied to Santa Monica afterwards. As i am in Seattle they did not want to accept me first but i'm a persistent guy, you know.

Yes, 100%. No same site, they rejected me at first because of wrong answers in the questionnaire, i objected and fought, changed my answer and made my way in.