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My brother is a professor at a university and while they don't do research, most of his free time is consumed with grading work, developing the curriculum for his classes, advising students, and planning for the next semester. If this will allow Dr. Shore to be free from those responsibilities...

2 yr TT anniversary last month.. I'm managing T okayish but dealing with random bouts of aural fullness/distortions in my left ear now.

Sorry to hear man, that's pretty ridiculous that you were so close only for them to turn you away like that. It's sad that they supposedly have something but only keep toying around about it. I'd like to hope that the Boehringer Ingelheim venture goes somewhere since that's involving big pharma.

I know we all have our reservations about Hough Ear Institute, but they just posted their 2022 recap which talks about the first person dosed with NHPN-1010 thru the FDA's Compassionate Use program. Obviously take this person's story with a grain of salt, but tinnitus resulting from removal of...

This is a particularly good find as the FDA has begun their review of the New Drug Application for AXS-05. Axsome Therapeutics Announces FDA Acceptance and Priority Review of New Drug Application for AXS-05 for Treatment of Major Depressive Disorder

Did your tinnitus return to baseline afterwards?

I wanted the white Phanteks P500A for the longest time because it looks the cleanest to me. I settled with the Lian Li as the Phanteks was always OOS or Backordered. I've been really happy with the Lian Li and the temps I'm getting.

I'll throw my rig in. I lucked out and managed to snag the CPU/GPU at MSRP. CPU: Ryzen 5600X GPU: EVGA RTX 3080 FTW3 RAM: Corsair Vengeance 32 GB DDR4 Case: Lian Li LANCOOL II Mesh White Monitors: 2x Acer 32" monitors (forgot model) Extra Stuff: Corsair Commander Pro, 6x Corsair QL120 fans...

Got my second Moderna jab yesterday. I'm feeling pretty tired and achy today so my tinnitus seems to be more annoying than usual. I don't think there's an actual spike/increase though. I was also hoping I'd be one of those blessed with a volume decrease.

Most hearing aids these days have Bluetooth connectivity so you can connect to your phone, tablet, or TV and take calls, listen to music, and watch movies through them.

I think they're going to continually update the trial page with additional locations. I don't believe the trials listed on ClinicalTrials.gov are limited to US locations only.

RNID hasn't updated their clinical trial pages since at least last year. If you click on their ClinicalTrials.gov link, it leads you to the OTO-313 Phase 1/2 and not the current Phase 2.

They should have all of the tinnitus data available with the complete readout later this quarter.

Since causes of chronic tinnitus are so varied, I think it'll help a subset of sufferers. Regardless, I'm going to try it out whenever it's released.

The point I'm trying to make is that the more beneficial SPI-1005 proves to be for COVID-19 and COVID-19 symptoms, the faster and more likely it'll be released. I literally want Sound Pharmaceuticals to strike while the iron's hot. We both want the same thing.

Their current COVID-19 Phase 2 trials seem to focus more on non-vestibular symptoms of COVID-19, oxygen, and oxygen saturation. They haven't updated their Phase 2 trial pages since November which lists the trials as ending in April 2021. SPI-1005 Treatment in Moderate COVID-19 Patients I'll...

With the recent review from the University of Manchester identifying a possible association with COVID-19 and long haul COVID-19 causing/exacerbating hearing loss, tinnitus, and vertigo, I feel like it'd be a great opportunity for Sound Pharmaceuticals to trial SPI-1005 in treating these...

Got the first Moderna dose on Tuesday. I thought my tinnitus was spiking but it was the same day the FX-322 news came out so it was probably stress and hyperfocusing on it at the time.

Not up on ClinicalTrials.gov yet. Otonomy Initiates Phase 2 Clinical Trial of OTO-313 in Tinnitus

I'm also very curious on how the Phase 1 worked out for you.

The trial is slated to end June 2021 with results out Q3 2021. FX-322 in Adults With Severe Sensorineural Hearing Loss

Their Phase 1 was encouraging enough for them to pursue a Phase 2. This doesn't detail out the exact data from the trial but does provide a pretty good overview. In First Test, Specially Timed Signals Ease Tinnitus Symptoms

She's been taking her sweet time, but barring another pandemic, their current Phase 2 trial should conclude this year with results out middle of next year. Medical devices only need to go through a feasibility and pivotal trial before applying for FDA approval so presumably if the results from...

Hopefully Otonomy is still on target to initiate their Phase 2 in Q1 since it ends in a week.

I say this half jokingly, but they should offer Compassionate Use as a preventative measure from further gaming of future trials. If anything, doesn't this show just how far people are willing to go for some sort of relief?

Would be great either way... as bad as the news was today, I still want the goop in my ears ASAP.

This isn't related to the Bionics Institute but is about measuring tinnitus. The Hearing Health Foundation is hosting a webinar on April 19, 5PM EST, titled Measuring Tinnitus and Reactions to Tinnitus. The synopsis for the webinar is: "Tinnitus, the experience of hearing sound without an...

Left hearing aid stopped working randomly. Oticon really has some shoddy quality.

They made the announcement in their October 29, 2020 press release. Frequency Therapeutics Announces Expanded FX-322 Clinical Development Program and Upcoming Day-90 Phase 2a Analysis

Their clinical trial page went up today. Under Arms, they explain how the actual and placebo devices are different by rotating the transducer. Evaluation of the OtoBand as a Treatment to Reduce the Perceived Loudness of Tinnitus

Oh, no worries! I was just trying point out where in the presentation he mentions the effectiveness of their drug delivery system. I actually tried to edit my post right after I submitted it, but it wouldn't let me for some reason. I didn't mean to come off that way and apologize if I did.

I'll also throw in a vote for Jonathan Kil at Sound Pharmaceuticals.

I can't say for sure, but I'd expect them to keep the dosing consistent to support their Phase 1 data. A few seconds after the timestamp I mentioned, Weber does say that they have gotten very long term exposure from a single dose of both OTO-313 and OTO-413.

Otonomy presented today at the Cowen 41st Annual Health Care Conference. Starting around 19:38, Dave Weber talks about their decision to conduct the exploratory trial rather than moving onto the Phase 2. It looks like the reasons are because they want to look at Speech-in-Noise (SIN) more as a...

Otonomy has enough funding to at least get through the next set of trials for OTO-313 and OTO-413.

I work for the state government and even we're switching over to permanent WFH. Pretty amazing how stuck in its ways the government usually is, but they're enticed by the savings in not having to lease buildings and renting out space in the buildings they own.

Pipeline Therapeutics announced the initiation of their Phase 1 clinical trial for PIPE-307, a drug targeting remyelination. At the bottom of the press release under their About, they state that they're still currently enrolling for their PIPE-505 Phase 1/2 which seems kinda... weird? Based on...

I get kinda bummed when I look at pics from the day before my worsening happened.

They actually are recruiting at some of the trial sites according to Jonathan Kil at Sound Pharmaceuticals. I believe the Michigan test site completed recruitment according to some of the other members here. If there's a test site you're interested in, I would reach out to Sound Pharmaceuticals...

Would a method like this possibly remedy the issues other firms like Frequency Therapeutics are having with drug delivery? I know everyone's coming up with their own methods, but all of these firms attend/speak at the same conferences every year. It'd be great to see them bouncing ideas and...

So I'm pretty much done with this trial aside from the close out call on Monday. They had me wear two devices separately for a week each. The device is a transducer that rests against the bone behind the right ear and vibrates. There's different levels of vibration and I was told to adjust...

I'd be pretty happy to fix my hearing loss, but it'd be like a second chance at life if I can get rid of/significantly reduce my tinnitus.

For those in the US, I'd encourage everyone who either got tinnitus or had their tinnitus worsen as a result of the vaccine to report it to the CDC's Vaccine Adverse Event Reporting System (VAERS). There's been anecdotes of tinnitus resulting from COVID-19 and remaining in long haul COVID-19...

Professor Fuchs did a webinar back in January on the ear, hearing, and upcoming treatments for hearing loss. He talks a bit about genetic deafness and how gene therapy can address it. He also seems pretty positive about hair cell regeneration as being a thing. I just skimmed through it, but...

The whole market is doing pretty bad today.

Ugh my BP has been high since my worsening.. it really isn't just a sound, it's so much more.

Should be $57.60, not $87.60. It's spiking up and down in the after hours right now.

If it wasn't for the Phase 1 extension for OTO-413, I would have. If Hough Ear Institute/Oblato manages to initiate their Phase 2 trial this year, that would actually put them ahead of Otonomy and Pipeline Therapeutics. I do wish they'd just tell us what's going on straight up.

Just curious if you're still taking the Nortriptyline and if you've experienced a benefit or worsening while taking it? My doctor prescribed it for my anxiety but I'm unsure about taking it.

Thanks for the data! Looks like the effect, if any, was inconsistent. I'm looking forward to your in-depth write up.

I did notice after a few days that I developed a beeping tone, but thankfully that went away. A shame that it doesn't seem to work because of the glowing reviews, but they could just all be paid actors.

Are you still using AudioCardio? If so, have you noticed any benefit? I tried it for a month and didn't really notice any changes in my hearing and tinnitus. I'm contemplating sticking with it for a few more months.

On this note, I feel especially bad for veterans who devoted their lives to their country only to be rewarded with things like hearing loss, tinnitus, and PTSD. It's like the fight never ends for them.

The world needs to know that losing hearing could mean hearing much more than we've ever asked for...

Some days I do, some days (like today) I don't. I miss when my worries used to be relatively trivial and transient.

Frequency Therapeutics hands down.

They do state that this number is for moderate to severe tinnitus sufferers so they've probably narrowed it down to a small subset of the tinnitus population. If they were to take into account all severities it'd be way, way higher.