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I wish these tests were ready and sort of fast tracked. Mainly because this might actually help me the best.

Hearing loss can come from several places. The loss of the hair cells, the loss of connection between the nerves and the hair cell, as well as the loss of the nerve cells. Currently, there is no way to look at any of those directly except post mortem methods. So, we use audiograms to give us an...

But what if that same person can't hear 14 kHz? Should we not test to catch that? Also, there's a general curve we can find for when people lose that hearing if we collect the data. This would make the above statement false, because we'd have a general idea of where you should be more...

Always happy to see more research, at least. And hey, maybe they'll both help?

Nothing says they can't try the neurotrophins this study mentions. Wouldn't it be something if they just have to replicate Spiral Therapeutics and Rinri Therapeutics' pathways to the ear, get some neurotrophins in there and that speeds up the painfully slow nerve repair.

I would say the really good thing is if the device does help people, an infrastructure will be built around it. You'll stop being told "Oh, there's nothing we can do." If you have mild to moderate tinnitus, you'll be recommended the device. As part of it, extended audiograms will become more...

Yeah, you have to be able to hear your tone. This makes me sad, because I know I can't hear mine anymore in either ear. So, I'm going to get left behind.

And hopefully Rinri Therapeutics will have gotten a good human trial or two in.

Yup, thank you @annV.

Can someone get the preclinical data? Restoration of auditory evoked responses by human ES-cell-derived otic progenitors.

I mean, it may take time, but with human ingenuity, I believe there could be a way back from it. Hell, we transplant people's hearts and livers, if we could just figure out how to make nerve regrowth faster, who's to say we couldn't grow a new cochlea and connect it, or get what remains to fix...

Hope you're doing well, man.

I mean, yeah, support professionals move in to try and help and cost some funding, but in perspective, ALS got $200 million in the year of 2022. Tinnitus research hasn't even reached that level total as far as I can see, and the ATA states that they have in "the last 35 years, we have...

So we would need both, a treatment for the brain, and this treatment to prevent it from getting to the brain?

People want the border secured it would seem according to Gallup, but a plurality feels that the support we give Ukraine is enough, not too much. This is based off of Gallup polls in October. Saudi Arabia supporting a country isn't a good sign. They've supported and financed our enemies across...

I don't understand how this is the answer when cutting the cochlear nerve doesn't help tinnitus in 55% of sufferers. Maybe it works for some, but tinnitus seems more like a brain thing to me.

The issue is that there's no clear guidelines or fix for tinnitus, yet it's also not tragic enough. People don't become unable to walk, crippled because of it, nor do they pass suddenly. Also, for many, it's livable, or a lesson. They can habituate, or it goes away on its own. Experiencing...

Glad to see it should be over. We have a lot of work ahead though. We can't stop at just electing the President. It's scary just how divided we are.

They're not even done with the current trial, nor are they likely to tell you when they plan on hosting the trial before they notify ClinicalTrials.gov. That's important info that can influence stock price, as well as company perception. They're not just going to tell some random that emailed...

Promising research. We'll see how it pans out. The regrowth of the IHC, which were essentially non-existent is very promising indeed. Though the chaotic nature is a concern. Still, impressive.

Seems to have gone more from a tone to a hissing at this point. Hasn't really gotten quite from what I can tell. I'm just scared, but I try not to think about it. I really hope FX-322, comes out with positive results next year, and that it can help me if this isn't working to resolve itself...

The channel Atun-shei films goes over it pretty good too. I enjoy his "Checkmate Lincolnites!" Series. I'm actually familiar with the arguments Lumen is making from it. Granted, I've never seen such opinions in the wild, until now.

Crusader King's 3 just came out on Steam, and I need to get used to all the options for it, as I really want to enjoy the weird stories that develop. I always enjoyed the family stories that Total War Kingdoms 2 gave me, and I hope I can get the same results here.

You're vastly mistaken on that history. I see you've been reading the romanticised and vastly edited civil war history that the daughters of the Confederacy put out there. The rich socialites of the south, that wanted to maintain their old way of life as best they could. The south attacked...

I'd argue most of our societal problems today come from the botching of reconstruction, and leniency provided to traitors with the idea they would act in the best interest of the country. We won the war, only to turn our back on the actual battle, because the north won it's victory and the...

No, Shore's device is more specific, from my understanding.

Would you rather be a poor white guy in America, a poor white woman, a poor black guy, or a poor black woman in America as it exists now? That sentence, although a bad way to state that black people have a rougher lot in society, is just saying that it's worse to be black and poor than white and...

I mean, it's human to talk about our frustrations, but if you don't know what you've gotten, it's best not to even mention your results. I also suspect that for those who got the placebo, it's more likely they'll break the NDA, as they have more frustration and reason to complain. It's similar...

Ugh, someone else broke the NDA? FGG's points are right about how this will affect the study. I wish these people would stop just throwing that they "received FX-322" when in the next sentence they go on to say, "Oh, I might have got the placebo." Let the science happen, guys.

It has more potential than just tinnitus, with possibly being able to restore movement to spinal injuries. That's more the reason this was given Fast Track, I feel. That, and it has enormous potential for actual brain research.

Alright, that's fine. Looking for more information is always good.

I mean, I agreed with you that severely limiting or getting rid of Police unions would help. I just also stated that we don't really have data on reallocating funding either. DaveN agreed too. As for police unions and politics, here's a good overview...

I hope it improves for you. I don't really know what to say, other than that. I wish I had a cure here for everyone, as no one deserves this.

Is it funny? Because those claims are clearly wrong. Also, seeing speech in noise improvement is important. If FX-322 can fix what remains of my high frequency ranges, and resolve or lessen my tinnitus, I don't care what it takes for them to get it to market.

I would say you shouldn't seek to reform a violent cop, but at the same time our system encourages cops to be violent with David Grossman's "Sheep Dog" mentality. Also, yes, the union would make it harder to fire them and as well as make it so they have more agreeable labor contracts. That's why...

@Justin De Moss this is what @ACJ is referring to. Tommy said Hough said it. I can understand your frustration with the accusations being thrown around. I hope Hough manages to find funding for the trial. I think a lot of the frustration on the forum comes from many members' inability to...

I mean, Luman isn't fully wrong about police unions. Getting rid of them would help. At the same time, I'd rather preserve unions, just have there be more oversight on actual hiring. Bah, that's a sticky road. The unions are why the cops are able to hold on to their current pay and such, but...

@Justin De Moss, Have you looked at talking to the Les Paul Foundation? They seem to be doing good work on trying to get the word out as well.

I really hope that FX-322 is the breakthrough they need to give ENTs a reason to actually focus more on the ear, and treat people.

It hasn't ran through the rest of us yet, though. Further, to say that it's only 0.0005% of the US pop is remarkably dismissive of the lives of those who have died, and the others that will die because of it.

You're right, we'd have sponsored doctors selling us the Sonus Complete Tinnitus Cure under a more libertarian system.

Same. Really shocking how lackadaisical they are with holding corps to account. Certainly not how Teddy would have dealt with them. I'd rather pull away from this discussion, though, as it's not really getting anywhere. Although I applaud your choices that support the local community, as the...

I'll agree that government regulation slows down biomedical science. That's not a liberal thing, that's an everyone thing, though. For example, stem cells. We have regulation there, and some want to go so far to prevent ALL stem cell research, not just research using abortions as a stem cell...

Dude, that's not how markets work. If someone has a monopoly on something you want/need, you're not just going to go "Guess I won't buy here." Normally, cause it's cheaper. That's what markets are meant to do. Further, this is the same "individual responsibility" talk corps use on climate change...

GDP per capita is an average. Averages are notoriously bad at hiding the actual state of affairs. Just because a billionaire enters the room of a bunch of minimum wage workers doesn't mean that everyone suddenly makes the average. What's better at determining desperation and the state of affairs...

But they're not. They may suck at other things, but I think when it comes to COVID-19 they're moving as fast as they can.

What makes a country more violent is desperation in the populace. The feeling of being trapped, and the only way of moving ahead being to inflict pain on others. The ability to distance oneself from the pain you cause to others too. Whether the populace has access to firearms and weapons is...

Yeah, due to the type of treatment, but I'm still happy to see progress.

So, the Minnesota device showed clear results, so bimodal stimulation isn't useless. There's also just recently been the results of a 5 year study where in the Netherlands I think, we they had an implant deal with tinnitus as well. It reduced it 50%. So, it can work, when done right. Lenire's...

Well, I don't like the prospect, but any move forward at this point.

Did you get an extended audiogram? They tend not to go up to 16 kHz, but those levels are actually pretty important, and could be where your hearing loss lies. Then again, at this point it's probably better to just give it time. Take this as a lesson for your kids though, be certain to let them...

Eh, if they can actually improve this then I'm not against it. Having FX-322 and neuromodulation as an option instead of just FX-322 works for me. The more effective ways we have to treat this monster, the better everyone will be.

Actually, I take that back. It's working on Calcium ion channels as well, so maybe it can help.

Well, true, but I meant as in even "stress" induced tinnitus. You are right though, the FX-322 trial should clear it up.

I wonder if they have already started a study looking at tinnitus ears as well. Would be nice to have further proof of it being hearing loss so they'll have less reason to treat it as nothing to be worried about.

I would agree it's probably treating acute. That's what most people are trying to treat, because it's what the army wants.

Oh boy, Austerity measures! Because those always work, and are never directed largely at the poor and middle class. Then again, we can't tax like we used to now that we live in such a global world. Every time we try and get the upper class to actually pay for the society that allows them to...

I see where he's coming from, but I would counter that his way of doing things seemed to be better than Lenire, and by trying to guide Lenire with an inferior device setup, he might improve it somewhat, but still not be able to help as much as his own devices could.

https://hms.harvard.edu/news/upending-dogma Turns out it is by and large just hair cell loss. With new technology, they were able to see the individual hair cells more and identify the losses. The model for human hearing that was made from whatever ancient studies they pulled this dogma from...