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Dr. Shore for 2024!

I think Taurine helps me very slightly have more good days and less bad days. I've had no adverse effects with 5g of this stuff almost every day: BulkSupplements: Taurine Powder

Whatever it is—a brain problem, a nerve problem, a cell problem—I have a feeling that when we figure out how to cure it, the knowledge we gain will be huge for many people, not just those of us cursed with tinnitus. The cure is going to be tremendous, much like the antibiotic revolution that we...

There's no pre-alignment. The FDA will delay for any reason they can find. They can and will demand more information. The more information given to them, the more they want. They will thoroughly exhaust everything within their sight before approving anything. This is why people have to be...

Even though I don't have Meniere's, I'm bumping this so SPI-1005 will get noticed by those of us who do have Meniere's disease involving tinnitus. SPI-1005 looks to be the next drug on the horizon for us to try. I still have a tiny bit of hope left even after the recent, highly disappointing...

Like I said, I may be wrong, and after reviewing it again, it looks like I was wrong. I got the 10 seconds from here, under the Intervention section: Reversing Synchronized Brain Circuits Using Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts It says: "Open-circuit and...

I may be wrong, but gathering from the device's study, you are not being barraged with a continuous, loud audio tone. The audio stimulation signal only lasts for 10 milliseconds, followed by 10 seconds of silence. 10 milliseconds of audio is barely anything relative to 10 seconds. I mean it's...

I'm a little surprised how simple the audio/electrical stimulation waveforms look. This is not a difficult thing to do from an engineering perspective. What does look difficult is the calibration. It looks to me calibration includes factoring in the participant's audiogram, and the...

Thank you, Hazel! So glad you stood up to these gaslighters for us. The Jastreboff model is a crock, and CBT for tinnitus is another one that needs to die.

Maybe the trial wasn't long enough? A long time ago I severed the tip of my finger. I was told it would take about 2 years for sensation to come back after it was reattached. Guess what happened - some feeling came back after 2 years. It still feels a little odd, but it came back. I wonder if it...

It's OK to cry.

My understanding is the highest frequencies are treated first due to the nature of the way the drug travels through the cochlea.

Tinnitus sucks

Yeah, I've got something very similar to Rick's. Mine is 1-3 days of at least 100 dB at 12.3 kHz, then 1 or 2 days of what sounds like a vacuum cleaner in the next room. Apparently some people get used to it. Not me.

I didn't handle it well at first either. But after a while I sort of forgot about it. Then it came back with a vengeance and somehow I went through the same cycle of not handling it well. I hope for your sake it sorts itself out and we never see you again, but we'll all be here to support you if...

I check the Research News forum quite often, hoping to one day read about a breakthrough. We could all really use one.

So much research going on

Sounds like a plausible solution and now I have many questions. Primarily, how could this be such a simple concept that we've overlooked?

Nice interactive here: https://www.frequencytx.com/speech-perception/ Looks like it focuses on addressing high-frequency hearing loss.

Here's another one - In-Depth: Why California's vaccine mandate presents 'impossible choice' for some with tinnitus

Can we glue a smoke detector to the side of Jastreboff's head and set it off right before he wants to go to sleep every night? After about a year or so of that, we'll see what he has to say about his TRT. All in the name of science, of course!

I wouldn't worry. You may already be getting Taurine in your diet somehow, not even being aware of it. It's very likely Taurine won't do anything at all one way or the other for you. Some here report taking relatively high dosages with no benefit to their tinnitus. But, there's a post here by a...

I estimate I've been taking around 2,000-2,500 mg 2-3 times daily. When it's very loud I perceive my tinnitus almost like a barrier between the outside world, and my head, if that makes any sense. Other times yes, it's a dull ringing perceived in my head. I encourage you who haven't tried...

I've been trying Taurine for the past month. I happily report to you all that, for me, Taurine does appear to take some of the edge off tinnitus. In particular, the ear pressure sensation, the high frequency annoyance, and the good/bad days ratio. I've tried many, many supplements, and so far...

The problem with analogies is sometimes people draw the wrong conclusions. Anyone who's ever disconnected a guitar from the cable without turning the volume down on the amplifier first has heard that distinct buzzing sound. It could very well be that the nerves (cable) have been disconnected...

This looks like big news to me. Why isn't this news getting more attention?

Be careful, it can get louder.

The Five Tibetan Rites https://www.youtube.com/watch?v=j_bY6REpIPE

Why are we still seeing spikes in cases (like in the UK currently sitting at 68.2% vaccination rate)? I would expect with the vaccine rollouts the cases would go down. The vaccinated should attenuate the spikes somewhat if the vaccines do in fact work very well. This clearly isn't happening. Why...

Why are there so many people who support big pharma these days? It's like the vast majority of social media has been bought out by Pfizer and Moderna. Did we forget the opioid crisis they caused? Hospitals were understaffed, lacked beds, and had extremely long ER wait times long before COVID-19...

“Gotta have a little sadness once in a while so you know when the good times come. I'm waiting on the good times now.” ― Bob Ross

How about don't do another dose until the current dose shows efficacy and stabilization? What's majorly difficult to know about that?

Two reasons. Poor job of weeding out candidates and a poor dosage schedule.

Clearly Frequency Therapeutic botched the clinical. Yes, and I don't even care about the hearing loss aspect of it.

I don't know but I highly doubt my brain is re-wiring itself due to changes in the atmosphere.

If it's all in the brain how come my tinnitus gets dramatically louder before a rainstorm? Do you expect me to believe my brain re-wires itself prior to the rainstorm, then re-wires itself back the way it was a day or so after the rain is gone?

Seems possible there will be a cure for the majority of us in a few years.

When I swallow, my ears pop and crackle like that. I think it's the Eustachian tubes flexing. I always figured it was normal?

I would suggest anyone on the fence about the mRNA spike protein-based technology thoroughly educate themselves on the topic before making a decision. An exceptional amount of anecdotal evidence regarding these vaccines can be reasonably verified to be true, then compiled into probabilistic...

Jeff, please keep us updated with your trials of Stemetil. I would like to try it myself. It would be interesting to get a blood panel done just before you take the Stemetil and again a day later when you are seeing the benefit, then compare the two blood panels.

I've found eating two or three of The Ginger People Gin Gins Chews before bed will control my reflux at night. They taste pretty good and seem to be tinnitus safe.

I tried 'now' brand Butterbur. It didn't do anything at all. Recently I've been taking Jarrow Formulas MSM. Taking two 1,000 mg pills will clear up my sinuses for about 6 hours.

So you take the pill at night and it kicks in the next day? Does it only work for one day? How often does your tinnitus go through the two modes?

FDA Phase 2 is expected to end August 2022. Phase 3 will likely start months after that and take over a year to complete. Maybe late 2024?

When you unplug a guitar cable from a guitar with the amplifier turned up, you'll hear a buzz. The end of the guitar cable is picking up noise. It acts as an antenna and the amplifier amplifies the noise picked up. I wonder if this is an analogy for tinnitus? I may be completely wrong.

You want to help her and it's tough because you're offering advice you've heard from the 'experts'. The problem is the 'experts' don't have real solutions so it causes more stress for everyone. It's crucial not to become upset with her about this. If anything, be upset with the 'experts'. It's...

All perception of everything is in our brain. I don't see the point.

When you're ready, listen to it every once in a while. It may not get quieter, but it will get better.

I tried both Mirapex (Pramipexole) and Levodopa. They didn't do anything at all for my tinnitus one way or the other.

If I have a faulty gating mechanism, why is my tinnitus extremely loud one day, then hardly noticeable the very next? It's intermittently faulty? Also, people with Meniere's disease who get random attacks of tinnitus. That's due to faulty gating mechanism as well?

David, How do you determine what volume level you should be listening to the track? I'm a little concerned that if the volume is set too high it may worsen the condition. Also, do you think the playback volume is related to its effectiveness?

Maybe this has been addressed: Did they already test the 4 injections once a week model on rodents with success?

All they have to do is show the FDA drug efficacy to get approved for use. In my opinion they should have played it safer for Phase 2. Say it's only for high-frequency hearing loss, get approval for that, we can try it off-label. Meanwhile, they can work on improving the drug's delivery method.

Good things happen all the time.

Looks to me like it takes about 5 hours to reach the deep parts. You'd have to lay there for 5 hours with this thing in your ear. I would do it. Maybe they can knock you out first or they can refine the process to speed it up.

That's better than what I was thinking because they actually did it? We probably already have the technologies although integrating them is a whole other story. With the pace of the FDA process, maybe in my lifetime, I will see something. I still strongly believe this is better served by...

Would you say it's a subjective test? Some studies show actual physical changes due to the placebo effect. Combine that with the fact that a hearing test can be a subjective thing: Audiologist: "Don't raise your hand if you can't hear this tone I'm playing." Me: "I always hear a tone."...

I think that's highly unlikely. However, someone with prior familiarity would be more capable of maybe gaming the system to their 'advantage', maybe even unconsciously. "Yes, take poor me, I have trouble hearing," then after the drug, "Wow, this drug sure works great! I can hear everything now...

I don't have solid proof linking tinnitus to COVID-19 but my tinnitus got significantly louder late 2019 accompanied by some sort of pressure feeling in my ears. It also took on a new characteristic where it sometimes becomes much softer for a day or so out of maybe 10 days.

I wish this one was. I believe FX-322 as it sits today has a good chance of improving high-frequency tinnitus for some people, which could be a stepping stone to wider applications.