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I have a 55 dB hearing loss notch at 4000 Hz and a tinnitus tone to match it. I've had it for years, and for the last couple of years, I have been mostly habituated. I recently fell out of habituation because I went to a couple of loud social events. Of course, I wore good-quality earplugs, but...

I suspect there is going to be a whole lot of formerly deaf mice running around with perfect hearing before we get our hearing fixed :)

5 years in with tinnitus due to noise induced hearing loss in the 4 kHz range. Someone yelled in my ear the other night and caused a massive spike. Took 40 mg of Prednisone for a day and the tinnitus immediately dropped to below its usual baseline. I only had one day worth of pills so the...

My hearing loss & tinnitus tone is at exactly 4 kHz. I wonder if FX-345 will help, or if 4 kHz will be to close to the edge of the drug's effectiveness zone to receive much benefit?

If fixing tinnitus was as simple as just taking Ketamine, MDMA or mushrooms then we would all know about it by now. De Ridder is pairing the drug with other things, so unfortunately it is nothing that we can emulate on our own.

I've got a 60 dB hearing loss at 4000 Hz that causes my tinnitus. Although I've been mostly adapted to my tinnitus for the last year, I am having a bit of a spike right now, so I just got back from a hearing aid specialist and tried on some hearing aids. They really do seem to help my tinnitus...

Neither PIPE-505 nor OTS-413 are letting people into their trials who have "bothersome tinnitus". To someone waiting for a tinnitus cure, that seems like a bit of red flag.

I notice that they only talk about speech intelligibility. Have they given up on improving the actual hearing thresholds?

It's like a Chinese finger-trap. The more you try and solve it and the more you care about it, the harder it is to forget about it and start habituating. It's only when you truly accept it that you will stop thinking about it as much. This is easy to say and easy to understand intellectually...

Of course I don't know. Neither do you :) This is all speculation. Both positive and negative speculation work together to help us get closer to the truth. That's what I am interested in.

If chocolate protected one's hearing to any serious degree I would be able to hear a whisper at 1000 yards :)

Been here from the beginning. They had lots of PR a while ago but there's no denying that they have gone quiet recently. I've launched several startups in my time and what you want to do to have a successful product launch is build a community buzz around it. They started building the buzz...

So here's the good news. I've been in exactly your situation 5-6 times. I go someplace a little noisy (bar/restaurant/movie). I measure 80db. I use earplugs. Stay for an hours or two. Things are mostly fine that night but I wake the next morning to a big spike. Every time it has happened...

The irony is, so far the only "silence" that MuteButton has created for anyone is in their press releases and product updates for the last 6 months. The problem is irony is not a good marketing strategy and I am beginning to wonder if their current silence is just a cover for other problems...

I've gone from noticing/thinking about my Tinnitus 500x per day to between 5-15x per day. Some days I forget about it altogether. But... it took 2+ years to get to that point and if I go to a place with louder noise (a loud restaurant or movie) without hearing protection, it can trigger a 1-2...

With no objective way to measure, it's hard to tell the difference between actually louder and noticing the same level of loudness more. So I am not sure.

I notice it more when I meditate. So I don't anymore.

Neither of the 2 testimonials are people with hearing loss. I hope that the next person who comes forward has a bit of noise-induced hearing loss in their profile. Then I will really start getting excited.

This sounds good... of course there is no way to measure the volume other than perception. But I think that perhaps the difference is, someone doing these therapies might say: TRT - "I notice it much less throughout the day and it emotionally bothers me less, but when I listen for it is still...

TRT claims it helps 90% of the people who do it. The interview says there is a clinically significant effect on 67%. Can someone help me by clarifying why this is a better claim?

Glynis, although I don't know you, I can feel the warmth and compassion of your personality radiating forth from your many posts here. It seems impossible that your warmth will not attract similar positive energy back into your life again. I just hope your tinnitus doesn't ring too loud for...

Eye patching is effective only up until about 12 years of age. I did it myself when I was 4-6 years old and it brought my eye up from blind to about 1/2 of what normal vision should be. It doesn't do anything for adults though.

That condition is called amblyopia. I have it too. It has been considered untreatable in adults until recently. There is now new work being done that involves playing video games like tetris while wearing 3d (red and blue) glasses, in which they have finally been able to improve people's...

When they finally cure noise induced hearing loss and associated tinnitus, I wonder how many people will go back out to bars and concerts and give it to themselves a second time.

Actually the FDA hasn't approved it due to potential cardio-vascular issues. It's used in plenty of other places though...

Just to complete the internet documatation on this, it's now been a couple of weeks and my hearing test value at 4000hz has returned to baseline! T is also at baseline! So it was not a permanent effect.

Here is another thought... If the only positive excitation of the fusiform cells depends on input from Inner Hair Cells and negative excitation depends (partially) on input from Outer Hair Cells then Tinnitus and hearing loss at a certain frequency almost certainly means that your OHC are...

I loved the video but I see an inconsistency. If the auditory nerve input is the only input that contributes to the (+) positive excitation of the fusiform cells, then if it is cut, the only remaining input would be the suppressive somatosensory signal. Thus by cutting the auditory nerve, the...

Don't like this. It indicates to me that there are damaged structures in the ear sending out a bad signal. If that's the case then just growing new hair cells with Frequency therapeutics won't stop the tinnitus. You would have to somehow clear away the damaged structures making the tinnitus...

To be honest, I knew that tinnitus was a rare side effect of the drug... But it was supposed to be less dangerous than Ibuprofen (which I use on occasion without any problems) so I figured I could do it for a week without taking too big a risk. Still hoping it subsides but the hearing loss...

I recently was prescribed 7 days of anti-inflammatory painkiller pills for a pulled shoulder that wasn't healing on it's own. I researched the painkiller --Arcoxia-- and it appeared to be like Ibuprofen but with less known ototoxic effects. I take hearing tests all the time using my noise...

I agree. Since then I have experimented a bit with natural supplements and am currently trying Fish Oil. It might help a bit, but nothing like pred. Note that it takes pretty massive doses of prednisone to have an effect. When I was tapering and down to 40mg, the T and hearing reverted to...

Not logic so much as experimental observation. The first time I took prednisone was for an issue unrelated to my original acoustic trauma and hearing loss. I was surprised to note that my T reduced and hearing chart improved. I repeated the experiment twice and got the same result twice...

Maybe not entirely true. I have experimental evidence! There have been 3 times that I have tried going on 60+mg of prednisone per day for a few days. Each time there was a notable reduction in my tinnitus and according to hearing tests, that I ran at the time there was a 10db improvement in...

Why is it outdated? What is replacing it?

Got the puffy face but I never felt like it affected my emotions or thinking. Little rough on the stomach too as I recall...

No... never heard of it... have you tried it for your T?

Prednisone reduces my T too... but only at >=60mg per day. Too high for regular use. I have tried natural anti-inflammatory such as Omega-3 fish oil, but likely with limited success.

April 2016 - Initial onset after exposure to loud noise during sleep. Tinnitus mostly in right ear but some in left. July 2016 - Hearing tests done on Android app are confirmed by audiologist showing a 50 dB (moderate) loss of hearing at 4 kHz. Sep 2016 - Woke up to SSHL (and much louder...

When I was tapering and at 30mg per day my Tinnitus came back to full strength. Only while 60-80mg did it become muted.

Maybe... I took prednisone 3 times in 6 months. The first was for a week, followed by 2 weeks of tapering off, the next 2 times I only took it for 2 days each with no taper. It's been a year since then and I am about 15 pounds heavier than I used to be, despite my usual regimen of diet and...

Is there a location requirement? I am outside the US but can fly in perhaps :)

60mg of prednisolone has always muted my spike within 24 hours after starting it. (tried it 3 times, same result each time).

Anyone know how severe the hearing loss has to be? 55 dB at 4 kHz enough? Or do you need to actually be to the point where you are reading people's lips?

Don't be so USA centric. Any other country in the world can research something like this without waiting for the FDA. I nominate India. They are already good at making generic drug knockoffs....

Assuming Jeff Karp is at Frequency, maybe someone could email Jeff and let them know about these guys. Perhaps they could fund their research in return for use of their results or something.

Anyone seen this video on small molecule research. Part of what they are talking about sounds similar to Frequency Therapeutics...

Hopefully anyone who does this for hearing loss will be able to show before and after audiograms to demonstrate measurable improvement.

Tried a hearing aid in an audiologists office for 10 minutes. They were calibrated to match my 60db hearing loss notch at 4khz. The T was undiminished while they were on. Perhaps it is something that takes time to have an effect?

I don't get this. You see I am somewhat habituated now. Most days in the last few months I only notice my T 5-10 times... instead of 500-1000 times like before. But what I find helps habituation is involving my brain in work/conversation/puzzles/tv/reading ... all of which take me out of the...

Ouch... this really hurts the case that restoring hearing through something like Frequency Therapeutics will also cure tinnitus.

FYI, 30mg did nothing for my T, had to be over 60mg... which is nothing you would ever want to do as a long term therapy.

I took 60mg per day for 2 days. The first time it was prescribed by an ENT, the next time I just used my left over pills. I can't remember anymore what the exact breakdown was (?20mg 3x per day is my guess). I wanted to be on them for short enough a time that I didn't need to taper the dose...

I am 47. I have had my T for 2 years. It's really only in the last 2 months that I have come to a point where I can go most of the day without thinking about it. And that is a fragile state. If I expose myself to too much noise... say over 70db for an hour or two it gets worse for a few days...

I got my Tinnitus about 2 years ago. I have hearing damage at 4000hz (it is reduced by 45db - considered moderate), and that is where my tone is. If I expose my ears to loud noise, I generally get a spike the next day that lasts 1-2 weeks. I am currently having a spike right now as I went to...

I found that taking 60mg+ per day of prednisolone cut my T way down after 1 day. When I stopped after 2 days, it reverted to baseline. I did this twice, during spikes. As for side effects, it might be coincidence but my weight set point seems to be 5-10 pounds higher than it used to before I...

When I start to worry more than usual that my T is getting louder, it kindly obliges me by getting louder.

I noticed that when on high doses of Prednisone my T was reduced so I tried to find a natural anti-inflamatory to mimic the effect. Around the same time I started taking Fish Oil capsules, my T started to bother me less on a daily basis. T is still there, just don't notice it as much. Probably...