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There are a lot of NMDA Receptor Antagonists in the market. I don’t see the first one to help tinnitus.

With all these current "delivery" methods and only guessing what goes on inside our cochlea and our brain because no one knows for sure where subjective tinnitus originates, in 40 years maybe something will work.

FX-322 just failed. Or am I missing something?

Yes, 300 mg. How is working for you?! Do you take other medicine?!

Maybe hearing loss!

I want to know too.

People, I have been saying all along that there is a serious issue with the delivery method to the cochlea. If they don't find a method to get the drug into the cochlea, all these IT drugs will be failures.

I guess this is a dead end.

Are you taking lithium carbonate 300 mg?

Ebselen can break down skin pigments and reduce melanin in the body, which might increase the risk of cancer In yeast, ebselen may damage DNA and turn off genes that help reduce the damage High doses of ebselen can kill specific cells (HepG2 cells, hybridoma cells) Ebselen causes calcium...

That only makes you think that it will be a failure.

My doctor prescribed Lithium to me. I really need to try something that works for my brain.

Dayvigo is good for long term?

Hey, I think people are tired to hear that something may work only to realise it doesn't work. Do you know somebody that has tried it?

I think it will take 20 years or more. All these processes (preclinical and clinical trial phases) that it takes to test something to see if it works. When you see that they can create a vaccine (COVID-19) in less than a year and put it on the market, you realize that everything is a...

Where do you see that?

I got it. In the bad case scenario, where the severe group doesn’t see improvements, would that mean that FX-322 doesn’t work, what do you think? Or would it be a delivery method issue? How can we be sure what is the real issue?

I take this for now but is hard if they don’t show real improvements. 85% to 100% of success.

I’m sorry, but I really don’t see how this could have good results if they continue with the same delivery method to the cochlea. Can you explain that to me please?

They need to focus on how to deliver the drugs to the complete cochlea (INSIDE). I understand reaching the inside of the cochlea without causing damage is very hard but they should find a way, if they want success with these drugs.

I don't understand why these companies keep making the same mistake with the delivery method to the cochlea. Frequency Therapeutics, Otonomy, Pipeline. It is no longer about if the drug works or not, it is about the delivery method to the cochlea. If they do not work on the delivery method to...

What is the delivery method of this drug?

The truth is difficult to accept. Unfortunately, the reality is that FX-322 does not work in vivo human cochlea. The delivery method is where they have to focus on and this goes for all drugs that are injected intratympanic (OTO-313, OTO-413... etc).

If they don't find a delivery method to go deeper into the cochlea, I guess FX-322 will be a flop.

I don’t know if I can take this F... tinnitus/hyperacusis anymore. Doctors know nothing! There is no medicine, not anything!

Are you still taking Dayvigo? Is Dayvigo non-ototoxic?

@GBB, how did you cure your tinnitus the first time?

When did your MS start? When did your tinnitus start?

I would like to know too!

Haha, Yeah probably! but nothing is for sure with this experiments with the cochlea.

I guess they just need a higher dose of FX-322 and using low frequency sounds to reach the apex of the cochlea.

Maybe you talked about this already and this is a little old, but is this something normal?

Maybe. We will know one day. I think if FX-322 works for tinnitus, it should work for hyperacusis/noxacusis too.

@R. David Case, do you still have tinnitus? Yes or no?

Intravenous or intratympanic?

That’s the point. I want to add that stress in short term is like a boost to your body, for example your senses are heightened (like superhuman)! When I was young a friend had an accident where he injured his leg. He had normal pain but he had a stressful situation where we had to leave...

Happy but now in war mode!!

Yes, I guess the same thing! The fact right now is FX-322 works in frequencies from 8 kHz - 20 kHz, but that is not enough for the market, knowing that the most people with hearing loss are in the range of 0.20 kHz - 8 kHz! Of course many would benefit from FX-322 if they have hearing loss...

Hello!!

Will FX-322 work for me? Asking because I have hearing loss in my low frequencies.

I have the same situation, but I have had this just for 4 months. What do you do for sleep?

Turmeric is good?!

He has money to put in FREQ stock and disappear.

Ohh wow, did you take it for long term?

. What caused your ototoxicity!?

I know this an old post but how is the Ginger working?

Are you still taking Dayvigo?

What app do you use to buy FREQ stock?

I think he's just taking care not to say stupid things.

“We don't see FX 322 eliminating hearing aids. We actually see it... it could potentially be used in combination. You might have a subject that might be a candidate for a cochlear implant, and they could potentially be treated and then moved to being a hearing aid candidate. And then there might...

I do not understand how they can tell when the animal has or does not have tinnitus when it is something that is still difficult to verify in humans, knowing that animals do not speak!

We need to stop this, we need to go to the news, we need to do something.

Do you have the device!?

How is your TTTS?