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The idea of gating mechanism certainly isn't. I think the identification of this part of the brain as being responsible is new.

You probably don’t even need to buy it from pharmaceutical companies—just have a lab produce it since the molecules are already known. There shouldn’t be any intellectual property issues, as long as it’s not being commercially exploited.

Is there a thread here on migraine medications following Dr. Djalilian's talk covering this?

I agree 100% with this. In my view, there is very likely some existing treatment that is highly effective in many people but has been missed. This is why my idea was to thoroughly survey every treatment (e.g., summarising every study).

Yes, this is right. I remember the developer of NHPN-1010 said the same thing.

Very interesting. One thing that occurred to me (that others may or may not have thought of) is that a tinnitus filtering mechanism might have explanatory power as to the causes of tinnitus. I have seen many people say that drug x is ototoxic and caused my tinnitus. Whilst I have absolutely no...

Thank god for the studies in the Mongolian Gerbils. What would we do without them!?

@Tau, i saw you took HPN07? Was it successful?

Unfortunately, I suspect that the reason for this is that there is little financial incentive in these types of treatment. Both Lidocaine and Gabapentin are fairly common drugs and so there is no new proprietary drug which can be sold. The result is that once academics have published this study...

Tinearity looks like a glorified white noise generator.

People need to keep on topic. 99% of the stuff being posted is not relevant to aut00063.

Yes, I am a 'vegetation'.

This is neither the place nor the time to discuss the morality of animal testing. That aside your arguments are pretty pathetic.

Just to let everyone know that I'm no longer participating in this study. Since my initial visit the t has become intermittent and therefore I'm not eligible for the study.

Hi, Sorry for the delay in getting back to you. I'd say my tinnitus is around a 3 - 4. It gets worse at night. Emotions seem to have little effect. I'm due to be randomised in two weeks (there was a delay due to GPs being slow). I believe that this is when I will receive the injections. I...

The risks of MDMA are seriously overrated.

Do you think commercial interests are preventing the release of the study data?

So says Paul Feyerabend!

enrolled on am101 today happy to answer any qs

How on earth can he say that when it's a placebo controlled trial?

? I'm talking about the differences between the placebo and non-placebo drug. Surely, they should look the same for the precise reason given in this thread?

I know what you mean. The same thing happened to me.

If they're different then surely that's a severe defect in the design of the study?

ok thanks, should have figured that out myself...

Amazing news. How long after onset was your first injection?