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The problem with AM-101 was definitely clinical trial design. The animal model of inducing hearing loss on rats/mice and then treating them inside a window of 3 months only mimics the human case of acoustic trauma and otis media. But most tinnitus is due to accumulated hearing loss over a long...

It seems obvious, but it actually has me worried about drug and clinical trial design for tinnitus. There has been a lot (well, relatively in tinnitus research term) of research done on how to simulate tinnitus in rodents (inducing hearing loss, training behavior on tinnitus sounds, etc) , but...

I was surprised that this company has gotten funding for developing their own implantable VNS device, the technology they are developing is not revolutionary different then any other VNS company in the market. Also, with the existence of transcutaneous vagus nerve stimulation (t-VNS) this...

I've been following AM-101 for a long time, it's a tragic setback that it failed, but imho it's not really a surprise. First, previous trials have been done with the oral NDMA antagonist drug neramexame which failed too with insufficient efficacy. Of course there is a difference between oral...