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I felt pretty bad when I saw the news about the failed trail, but I was doing well at the time. I had a bad spike after a motorcycle journey recently, so am back on the forum, getting by on promises of future glory. Things look better than when I last looked for tinnitus treatment. I hope that...

I do wonder what the impact of the diet etc. of those in these studies is on individual outcomes. Many people carry around one or more micronutrient deficiency and modern diets have many setbacks and you can only screen at the most extreme end for trials like this.

But Elon is very good at commercialisation at scale. Also, the performance of all the rockets that exploded was rudimentary, until they didn't.

I'm going to inject what I can, snort what I can't, then chase with vodka.

*Hearing loss and tinnitus drugs in trial pipeline* I am not sure how much closer you can get, there being multiple drugs in the clinical trial pipeline. Multiple Phase 3 trials would be nice to see, I admit. It's no given, but comments like this (which 20 years ago would have been considered...

So the incidence rate of 10% or more improvement rose with multiple doses? Although the rate of larger scale gains decreased? Or am I wrong?

In the middle of a terrible spike, for ten quid, I decided to give this a go... Some peaceful dreams would be nice :)

I am unsure that this is a given... Can't injection of a placebo have harmful effect, due to physical phenomena alone?

I am the opposite, I never have spikes, just changes in attitude when it gets too much to bear... I guess this means that I am in the pool of people it probably won't work for :(

I have devoured so many of your posts that it feels like conversing with a celebrity! I am an engineer, not a scientist, but digested the 2009 paper on the development of Ebselen. I can't find the 2021 February paper using my sources. The 2009 paper suggests, like you did, that the primary...

Sorry all, another refugee from the FX-322 thread here... Having worked that thread for over year and jumping ship to skim read the last few pages here... It seems that this drug has had good results and is even oral! In my mind this is even better than an injection because... No injection. I...

Checking in for the first time in months. The news didn't do me any good, but the ongoing analysis is super appreciated. Feeling informed feels better, even if the info is for the better or otherwise. June does not seem too long a wait. Cheers guys and girls.

Same way doctors actually know very little about HOW what they do works. I mean, you can learn this at med school, but no practicing local GP is going to remember the mechanism by which the all of the drugs they prescribe act, or we wouldn't have enough doctors - the cognitive burden would be...

They can impact your handling of ANY challenging stimulus.

This is the man who made the viable electric car company. Then made it self driving. Commercially viable without subsidies. Who then got NASA to apologise to his company because they favoured Boeing. And landed the rockets on their backside. I am an Engineer, so possibly biased... but I like...

So at a random sample this would be 1/4 for two to get placebo. But in my head people who it works for are more likely to stay quiet. They got what they wanted, so go with the NDA and don't make trouble, right? So I don't think this is representative.

Hi there - so is this thought to be bad news from a development perspective (independent of timelines)? Is there scope for them to modify a trial mid-trial in order to improve results if they don't look good?

Thanks for staying on top of this guys and digesting the information by discussing it back and forth. It's super appreciated.

There is precedent of this happening.

Would this work, or just compress the gas in the inner parts of the inner ear, advancing the drug down the tube only incrementally?

The question is intriguing, but extreme and at a great disconnect to the reality of where we currently believe ourselves to be with this. I am all for the placebo group in this instance especially; we have a condition that is VERY hard to measure and may change naturally over time (I believe...

Hope so! Trouble is I can't help but feel that the exposure decay will be exponential within the cochlea - a bit like dropping a blob of paint and examining the volume that remains inside a given radius of the impact. Given such a decay it could need a LOT of drug to have any impact.

Phase 3 might not be required however.

I want to include a disclaimer with this one, and don't mean it for you necessarily, but others lurking. These 'online tests' are VERY biased to the speaker set in use. For example small earbuds will often replicate higher frequencies better and make them sound louder. But with age the higher...

Also you may want to look into residual inhibition and reconsider your assumptions. I am not saying you are wrong, but residual inhibition, to me at least, suggests that there is more than just masking at play here...

Wait what.

Again people, some drugs are released on phase 2 data. See my previous post :)

47 days!

I am, I'm building this as soon as my current project is done :)

https://www.forbes.com/sites/aroy/2012/05/04/should-the-fda-approve-more-drugs-after-phase-ii-a-response-to-matthew-herper/ See the above link for the description of the 'conditional approval process'. This does happen. This might also be referred to as rolling review. Also see the link below...

Has anyone been accepted for Lenire treatment with non-constant tones? E.g. crickets?

My pet theory on all this is that the audio processing part of the brain has focused on a certain frequency set within the auditory brainstem. I think that the downstream processing regions adapt to this as part of the habituation process. When Lenire starts remodelling the auditory brain stem I...

@JohnAdams - Was it you that didn't have any joy with Ginkgo? I was wondering if I should try this with my curcumin. Am never sure what to believe though...

I'd do it. In fact these reports have convinced me to get on the waiting list for one. Change, in my mind, is evidence of function. Got an ENT visit next Monday. I will get the most extensive audiogram I can and then contact Neuromod.

Not that kind of funny. I have kept tabs on these discussions and take 3g a day. No benefit for me yet, alas, but given the topic of this thread... The hope that a herb will do the trick for us tickles my blacker sense of humor. No offense meant :) Especially to someone here to help!

We can't know. The link above suggests this is a possibility...

I hope this is the case because they are intending to go fast track and get approval (possibly subject to periodical review) with phase 2 data. According to the article I linked above companies will often produce very extensive phase 2 data when they intend to do this. I hope that the difference...

Thanks for the above; I am hoping that we might get an update on approval strategy at some point... Especially since this site claims, amongst a few other interesting things, that: Any news in this sense? With phase 1, 1/2, 2a and 2b(?) it seems Frequency Therapeutics are being robust...

I think I am am optimist, but I struggle to envisage them treating both ears in direct contradiction of the stated trial criteria and control? Not arguing with other aspects of statement though. Can we ask a follow up question?

Sorry, I have scanned the above posts, where is this? I'm probably being blind lol, today had been bad.

I appreciate you are a pessimist due to your experiences. This is very valid position to take. But what has really struck me is that most of the studies relevant to this stuff that I am referencing in the last two pages have been produced within the last decade. Identifying the cell types...

I don't know if you suffer from hearing loss, but I do. My tinnitus is far worse in the quiet, because it is more obvious to perceive. The world is filled with background noises. If I can better perceive these I know my tinnitus will impact me less. We know there are many different types of...

That sounds crazy promising. I'll look for a paper later "Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells,” EDIT: I have the above mentioned paper now. Got it through means that publishing companies don't tend to like, but feel...

I couldn't recall if we had seen reference to multidose treatment in rats for example, that would support the upcoming trial.

Thanks everyone!

I have a question in turn. Do we know of any lab results that support multi-dose performance? I know that it must exist... but I want to read it for hope lol.

Source: Adams, C., & Brantner, V. V. (2003). New Drug Development: Estimating Entry from Human Clinical Trials. SSRN Electronic Journal. This is also highly dependant on the field. I read recently that a major blocker for cancer-related trials was finding people to do the trials. This shouldn't...

Anyone got a capture scope that they can stick on one of these things? I want to black box model it and build one.

I to be honest fail to spot the 'naked greed'. Look at it this way - if it is competing with HAs then the better it works the higher the price will be! This will be produced in mass if it does work, lowering the costs. The drug you reference is for a rare condition. It is a one time treatment...

Hi all, I have 30 dB hearing loss (at some frequencies) that was partially inflicted through ear infections and partially through motorcycle riding and a headphone incident. The hearing loss I can cope with, the tinnitus I can not. I have hyperacusis or phonophobia at Dyson hand-dryer sound...

They will be looking at multi-dose trial. I guess the then preferred dosage scheme is dependant on results. No results in humans detailing regain of hearing yet. They have however said it will happen in a conference this year. I don't think we have this info yet. I agree this is a must-know...

This isn't an orphan drug though. The market is huge and to tap a real portion of that market they will need to compete with hearing aids...

My thought as well - I have 30 dB hearing loss so I should fall with a foot in the camp whichever way it wings for, high or low, rights XD. The pattern of cells remind me of honeycomb. I always imagine that, like bees, you may be better off starting with a pre-existing pattern. Fingers crossed...

I was wondering this as well? Let's say the benchmark is 100 million+ in funding injection and a partnership with a major pharma distributor on the basis of hair cell regeneration? Anyone know of this?

In before: "It worked, bye." XD

Just joined this thread from the dark of the research section. I am a skeptic about everything, but I hope to hell you guys find peace through this and will be following work an open mind! I'll follow soon after it we see it working :) I'm interested if anyone with NIHL had been found to be...

As I remember it was 8 8. Haven't checked today am probably wrong... :P

Part of me agrees... but what do we expect them to say and how long do we think it will take them to say it? Assumign that everyone present is familiar with their work... 8 people had the drug. No side effects observed (fingers crossed). An average of X db improvement was observed at XKhz. An...

It would be nice to see some long term improvement monitoring in the next study (or this one!)

Sorry - I have read it in full now. So yes FX-322 is 'combinational'. If this is the only such example then my hopes are still impacted - a one horse race is less reassuring.