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Last month OHSU discovered how the inner ear translates vibrations into sound at a molecular level. This month we now have a safe route to the inner ear. We march closer to a tangible treatment, seemingly with an accelerated step. We have no idea what could be conceived with this information...

How about a gene therapy that regulates all hyper-excitable circuits? Gene therapy targeting overactive brain cells could treat neurological disorders

If billionaires were swayed by message boards, they would not have the temerity to be wildly successful. He's not reading this site.

Johns Hopkins is running a trial during the holiday season for PTSD. They run trials during the holidays.

The discoveries continue. This one seems seismic. They've been waiting for this information for decades. The game changing discoveries keep happening month by month it seems. It'll take time, but good things are coming. CRISPR/Cas9 was used to assist in this discovery. Just awesome.

You're right, I wasn't clear. I've said in other threads that 2025-27 is an important timeframe, because if any company's tinnitus clinical trials currently going on prove successful, those years would be the ballpark range for it to be available. I should have said I was speaking in general...

Thanks, Nick. Missed that detail. Even better news!

You nailed it on the head, Diesel. That’s what it’s all about.

Very close friend of mine will get 2-3 minutes of ringing when he doesn't eat before he plays sports on Sunday mornings. It lets him know he's hungry.

It's another reason why the military is interested in psilocybin and MDMA. Clear PTSD, and soldiers will return to the front lines.

Trial ends at the end of the year. Cleaning up the data could take another few months. We should look towards mid-2023 for results the latest (and not to get our hopes up too quickly for a fast report). Then Phase 3 would begin, which could be another full year of the trial. It's why 2025 is...

I think the goal is to remove those who are attempting to enter the trial for their tinnitus and not hearing loss. If the treatment is successful in treating hearing loss itself but the tinnitus crowd is unaffected, then the tinnitus crowd ruins the trial. It's clinically correct to try to fix...

FDA has been very recently asked to get away from animal models since what works for mice/rats/etc may not work for us and vice versa. Sadly, this won't happen until after 2030. I'm sure they'll be able to recreate human organs in a lab and do extensive testing to fix damage. If regeneration...

Looking back at OTO-313's history - it seems it never had a high probability for success. SPI-1005 and Frequency Therapeutics' re-trial seem to have a higher probability for success. No cure, just treatments. We'll take it.

The trial ends in November. There will most likely be a quiet period to clean up the raw data and compile it into a report. Expect early 2023. It really seems like in 2025-27 there's going to be commercialized treatments in major cities around the world.

Counting my chickens, sure. It's in Phase 3 and they've had impressive results thus far. I think this one gets through.

If SPI-1005 can alleviate tinnitus in some patients, a lot of people with tinnitus are going to flock to this drug. That’ll be the catalyst for more competition in the space. Progress is slow, but there’s now a treatment for Ménière’s disease. Amazing.

Tried and true saying - don’t watch the stock, watch the business.

One difference with the new technology versus the old: Regeneration tech isn't a hearing aid or a device attempting to assist, fool, or reset the brain/ear. The goal is turning back your clock as much as possible by regenerating your body to its complete function. Sensory regeneration seems to...

That was the end of the COVID-19 bull market. Nothing specifically to do with any single stock, which is good news for the company! Bad news for the economy haha.

The other issue going against those with chronic tinnitus is that the majority of cases do get better over time. Google is right about that. Most do have it go away or they have it fade into the background. I have moments where I don’t hear my stuff and when I realize it - it comes right back to...

To piggyback on your comments - since clinicians don't know when tinnitus moves from the ear to the brain, it may be possible to think that if the ear is repaired, the brain could send less of a signal to the ear? Maybe that thinking is way too simplistic.

Considering the trajectory of treatments in science, this tracks. We'll start at repair. Once competitors can get their hands on this and reverse engineer it, improvements and alterations will be made. Science will continue its adolescent stage of regeneration into a more mature stage over the...

Opening New Doors: First Synthetic Mechanosensitive Potassium Channel The above sounds like it'll help in the future. If Xenon is the beginning, I'm sure synthetic potassium ions will be able to help cochlear cells in the future. Mechanosensitive Potassium Ion Channels are a big part of the...

I have read through a lot of your posts, Tom. If you're ever lurking around - thank you. Your story and the ones you posted about people you know have been a big help in my 2 months of being a part of this community. Cheers, brother.

May 10th, 2022. Horrible day. Horrible year. Just wanted to zone out from all the stress. Had no idea the Bluetooth headphone volume was already at maximum on my phone. Pressed play without looking at the volume levels. Eyes focused on that big triangle Play Button on my iPhone. The song that...

If you have the ability to get pure CBD with no THC in it out in LA, go get it. Take 5 mg and do an activity that requires immense focus. Count the pores on the back of your hand with a white noise generator. Anything to keep your mind off of it. LIVE in the success stories threads and get out...

I'm on Lion's Mane and have been since Day 3. Today is Day 64. Give it a shot. It seems like the only side effect is if you are allergic to mushrooms. My ringing has lessened to where it's in the background. No idea if it's because I'm getting sleep or if it's the supplements or just plain time...

I'd like to point out that this company traded 10.5 million shares between June 29th and 30th two weeks ago. Its average is 85 thousand. So the volume of shares traded was 123 times its average. Good lord.

It would be prudent to see some 13-F filings to find out if it’s retail driven or institutional driven. Not sure where or when to find them. Can anyone help us out? If the institutions are showing up, we have a signal from the noise. Nothing guaranteed, but if they’re betting heavy, we might...

You’re more than welcome buddy I have a mild but reactive type, which I’ve learned very recently. So I might be around for a long time. But I know that if it levels out or gets worse, something is coming to at least make life manageable. One day at a time.

Tinnitus research doesn't have the funding of sight or cancer research, but things are trending in the right direction. You're 20 - you have a fantastic chance at your tinnitus fading over months/years and/or going away completely. You'll see treatments in your lifetime. I'm 33, so we'll both...

What's coming in medicine are things we can't conceive of. We're not experts in the field. I wonder if there'll be a CRISPR program for hearing loss. You get tinnitus or hearing loss. They take your DNA, run the program, and then you'll come back for the mRNA edit and you're closer to "normal"...

Science and funding are a funny relationship. No politics from this next sentence, it's just what happened in our lifetimes: The world was shut down with COVID-19. The science community did nothing but fund and work together on something to get the world as close to normal as possible. The...

https://www.relmada.com/product-development REL-1017 is in Phase 3 trials now. It is focusing on brain hyperexcitability. We all know that's a major factor in tinnitus. This drug doesn't belong in the Research News forum since it has no focus on tinnitus, but for those with reactive tinnitus...

A week late but I’d like to report on the Melatonin: I don’t think it had a particularly strong effect for me. What does, however, is CBD oil from a NY medical dispensary. I use 2 ML at night and 1 ML in the afternoon if my anxiety is causing a tough day. Sadly a firework went off and I didn’t...

Check out the inclusion/exclusion criteria: FX-322 in Adults With Acquired Sensorineural Hearing Loss

Next earnings date is estimated between August 8th and 12th Q2 ends Thursday. There’s always time in between the quarter ending and the release date for the reports to be filed and audited prior to being released to the public.

I took Melatonin on day 8 post-onset. My tinnitus started calming down. I thought it was getting better. Weened myself off. Tinnitus got worse and I got stressed so it got worse. I took 10 mg time release Melatonin last night. I had an insane spike during a thunderstorm. I got 7 hours of sleep...

You're welcome Brian! Yeah I'm seemingly all jaw related from stress. I can move my head and change the pitch/severity. I can massage my neck muscles in my hairline and calm the severity down. Been dealing with tinnitus volume levels from 1 to 5 for the past 5 days. I've already seen...

Brian, I'd like to thank you for writing this. I read it with the intention of understanding you better. I think I do. Sorry you're a major case. Someone here recently said tinnitus is a bottomless condition. I agree. I'm new here, so veterans of the condition should be listened to and their...

You make a good point. Tinnitus is like a fingerprint. If I make a recovery I'll stay here to help others and give them the mental positivity they need to keep going. Tinnitus is a very lonely condition. We all need to pull together.

This is my mindset. I've been stung once, and that's all I need to never be careless again. In another thread, the advice of having earplugs everywhere is good idea. I have a plan for recovery and continuing passions, even in a somewhat reduced level. Whenever that can happen, I'll be waiting...

The hyperacusis didn’t fully set in because I didn’t let it. I told myself that mentally I’m okay and the sounds aren’t scary. It’s helped for some sounds but not others. Wonder if it had to do with frequency. Magically, plates stopped sounding like they were coming for me. I’m not sure what...

+1 to this. It helps. After my onset I dropped vaping (still going through that withdrawal), drinking. Fixed my circadian rhythm. Doing the whole supplement route (Zinc, Magnesium, B12, D3) just for blood flow alone. It’s not a magic fix and my purpose is not to dismiss the pain in this thread...

I’m with you brother. I’m two weeks in and I work in basketball gyms. The ref whistles are a no no right now so I’m home and I’m miserable I feel fortunate that I’m starting to notice it’s getting better very slowly already. Im sitting in a room with some ambient noise (the hum of a computer...

Hey Dave. I’m 2 weeks into cannabis withdrawal and I too got eye floaters. My ringing spikes when I’m too hot. I find that ice packs on the back of my neck help. @makeyourownluck has good insight. We might be riding this thing out for a few years. Do what you can and keep going!