Search results for query: *

No. I was assessed as 'borderline' and basically chickened out. I didn't want to lose my residual hearing and there are two or three trials of formulations going on right now that might help prevent that. That's my current excuse.

This is the one you're thinking of.

Treating cochlear synaptopathy wouldn't make sounds any louder. Just clearer.

That gene therapy is for vision. They use that example to suggest that when gene therapy for hearing restoration becomes available, it may not come cheap. I found the article hopeful because there are university trials in place as we speak. Loss of residual hearing is the main thing holding...

This is an interesting read: Fusing Biology with the Bionic Ear

Hearing loss and dementia. Two human conditions where you'd think that just a leeetle bit of government financing and proactivity could do a huge amount of good. Yet the heavy lifting is left to dinky little startups looking for their pot of gold at the end of the rainbow.

At least some of the IP was conditionally licensed to Frequency Therapeutics by MIT. It may possibly revert to them. I don't know. In this case, it was developed in university labs, funded by the taxpayer or charitable donations. That's one good reason. Assuming the IP is worth anything now...

I don't think so. I think he was suffering. Paranoia and aggression was part of how he responded. You know, thinking about it, I agree with you.

I'm going in for my cochlear implant evaluation in about three hours. I understand that voices can start to sound more natural over the course of days, weeks, or even months—it's highly variable.

If you were going to put forward a cautionary view back in the day, first you had to get past @JohnAdams. He reacted aggressively to any "negativity". Then you were made to feel like you were messing with people'' mental health. So it was never the best environment for having a balanced...

The womb is a very noisy place actually.

@Tau, didn't they do a trial (in Germany?) that determined that the drug did reach the site of action? It was a weird way of putting it. It was like the drug got where it was supposed to, because that is where it got. Speech-in-noise scores only became the main endpoint when it was obvious...

Both. I can just function in quiet with hearing aids. I can't function in noise at all. I've got every reason to at least get evaluated but I'm procrastinating. Everyone tells me they've come a long way in the last few years.

Close to profound at the higher frequencies. There's been a big drop off from 1 kHz up over the last few years, so heading south inexorably. Word recognition scores were poor as well which I think is just as important for cochlear implant evaluation. I haven't got the results to hand, sorry.

I saw an audiologist back in December who told me that a cochlear implant might be the next step for me. There are lots of things you can have valid anxieties about with cochlear implants. But along with all of them there was this other thought in the back of my mind. What if I do the cochlear...

It makes me wonder whether FX-345 was just there to project the idea that they had other options. FX-322 was going nowhere. Bring on the lawsuits. They deserve what they get.

So, no-one feeling a little angry at this point? Feeling that they've been led down the garden path by one of the greatest hype machines the world has ever seen? We're close to 20,000 posts by the way.

Feeling for all of you who invested so much hope. Cochlear implant for me I think. All the best.

I think the original IP that they started the company with is actually licensed to them by MIT. Any subsequent IP would be sold to someone else. So, not gone.

Who are they pitching to? Only possible answer: the stock market. They want to maintain the value of their individual stock holdings. Personally, I think just stfu, do the science, it works or it doesn't, let us know.

Sorry, I haven't got a source at hand. I'm sure one of the Frequency Therapeutics fans will. It was discussed ad nauseam in the Frequency Therapeutics topics.

One of Frequency Therapeutics's selling points was that it would supposedly not deplete the support cells. Once a support cell divides, one of the new cells becomes a hair cell, the other remains a support cell. I think that's how things were supposed to work. It's all a bit moot though if the...

The previous results still stand though? “In light of challenging financing environment, we intend to explore strategic options to advance and realize value from our pipeline including both OTO-413 and OTO-825, our gene therapy program for congenital hearing loss.” I think this means they're...

Sounds nuts to me quite honestly. Statistically significant says simply that there is an effect - possibly minuscule. It doesn't say that the effect is such that it's worthwhile pursuing. They're going to approve a treatment that involves punching holes through membranes for little demonstrated...

Cynical viewpoint: If they abandoned FX-322, the share price would tank again and they're all heavily invested. Or maybe they really believe what they're saying? Hope so. Clinically significant I would have thought. No point to it if the effect is not worth the effort.

One of the things that is sometimes recommended to maximise your speech understanding is to learn a musical instrument. Otonomy might feel that including musicians might skew the results in some way- bearing in mind that speech understanding is the primary measure. Perhaps musicians might...

Fasting and/or calorie restriction is believed to reduce inflammation. Inflammation is believed to affect tinnitus. Neuroinflammation and Tinnitus

I came across an article on autophagy that prompted me to try time controlled eating. I'm fasting between 8 pm and 10 am. Stronger individuals than me cut eating down to an 8 hour window. I don't have troublesome tinnitus. I do feel better generally but I made a few lifestyle changes at the...

I think you're winning.

And the good news just keeps on coming.

They're taking a hearing loss treatment to the FDA, not a tinnitus treatment. Any improvement in tinnitus would be a flow-on result of improvement in hearing. Improved hearing is the primary outcome. In any case, tinnitus is notoriously difficult to measure. If including tinnitus sufferers...

Answered in the post above yours. It's about getting a clean result in a clinical trial. It's not about equity.

It's hard to let go of though, isn't it. Like here I still am on page 636.

I think we know what you meant to say.

Look up 2 posts from yours :rolleyes:

It won't. Ninety percent of this thread is pure speculation based on almost nothing. My comment was mostly meant as tongue-in-cheek. But seriously, the pages and pages we spent discussion the minutiae of cochlea drug delivery because we all thought thresholds were important. Now it's just about...

If your grandma was unable to have children she couldn't be your grandma? Maybe I'm missing something... Anyway, did anyone else notice that Frequency Therapeutics are now considering speech understanding as the sole measure of efficacy for FX-322. So we can finally stop speculating about how...

There's a bit of a problem with your analogy

It's a silly thing to be arguing over really but anyone who's been here for a long time can remember people being stomped on for being too 'negative'. The greatest stomper of course was JohnAdams. Don't ask me to trawl through 600 pages to find examples.

Let's see. There's everything Frequency Therapeutics ever said until about a year ago.

Who would have thunk it? Hough Ear Institute has been discovered by Dr. Cliff.

This whole thing feels like someone's part-time project. I think with the lack of urgency you'd have to assume that the results have been unspectacular. Yet they mosey along... I hope I'm left with egg on my face. Eventually.

I think they are pretty much. They're both going for improved clarity. Frequency Therapeutics haven't talked about improving thresholds for a long time. Collaboration between these small biotechs seems to be nil.

Commences September 2022.

Pure bullshit spin. Nine people achieved statistically significant improvements at some point in the trial! Pity that at least four of them fell below statistical significance later on. Put it in two separate paragraphs and hope nobody notices.

Easy Tiger. Just sit over there and eat some of that other cake with no medication baked into it whatsoever.

They should call Lucchino for advice. :confused:

Pity we're a bit of a niche market. Otherwise that could go viral. It's kind of close to how I imagine it all went down.

Reading between the lines, they couldn't shift hearing thresholds either. Like Frequency Therapeutics, they're going for clarity.

At least they never shouted from the rooftops that they were god's gift to the hearing impaired. Unlike another outfit that begins with the letter F.

When the topic of auditory training has come up in other places a common response has been you'd be better off doing formal musical training. A similar goal but musical training works better. That's the tenuous link. Musical Training for Auditory Rehabilitation in Hearing Loss They would...

Formal musical training is believed by some to improve speech understanding. Google 'auditory training'.

I don't care about the numbers particularly but I do care about being able to hear sounds again that I no longer can. That includes soft talkers and cicadas in the evening. The audiogram is currently the only way to measure that. Without audiogram improvements you're also left with the question...

Yes, they're kidding you.

It's like a grieving process that's playing out. People are still trying to process the loss of something of great importance to them. While Frequency Therapeutics were doing a great job of raising money from investors they were also planting the seeds of future collateral damage to a group who...

...again.

I was hoping for both but I broadly agree with you. It was such a smooth change of emphasis we pretty much all bought it. I was hoping to throw away my hearing aids. But if FX-322 or some other treatment doubled my WR scores, that would still make a huge difference to my life.

I'm still skimming through this topic. Not sure why any more. Kudos to the three main contributors that remain. I found a recent review of the general subject of hair cell regeneration that might be useful. The authors note that support cells near OHCs are less plastic than those near IHCs which...

I think it's hard to be impartial whether you own stock or not. I kind of would prefer if people took their discussions about the stock somewhere else but it's no biggie. Just more pages to skim through. I don't think WR scores were taken into account when selecting participants for 1b. The...

What gives me a little bit of hope is the follow-up study they did on those super-responders. And the thing that gives me hope is the way most of them were declining off their 90 day scores. It's the consistency of that decline across participants which makes me think that the 90 day scores were...