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That depends on the individual situation of the cochlea after the damage - not everyone has severe to profound hearing loss. We have to wait until we know more and get some data from the trial. Maybe the power of the human body itself can solve some problems when FX-322 starts the sequence in...

I already mentioned the hyperlink, if you are interested in it you can read it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637947/ In summary if you have severe to profound hearing loss there could be a flat epithelium in the cochlea. The huge damage forms scars and can also eliminate Pillar...

I hope this is the silence before the storm concerning research news.

If the new head comes with new ears I could get rid of my old one, also a result that I could live with.

Birds learn their species-related melody by DNA and by hearing the melody of their parents/species. I remember I read a study about a baby bird that got isolated and released after a while to learn the melody. I think the result was that the melody was not that perfect in details, but I can't...

Sometimes you comment as a self-made scientist, sometimes you just want to confront people. If someone asks what he should do if this drug fails, I should not reply and tell him that there is many other research going on right now? What would your answer be? "The drug doesn't fail"? You...

There are many other companies/universities that work right now on the regeneration idea - turning supporting cells into hair cells. Frequency Therapeutics is not alone, there is already competition and it is great that more companies focus on the regeneration because by the end of the day the...

I don't think the information about the quality/impact of the drug helps anyone that is outside the trial... What would you do with that information? Buy shares? Penalties, court, etc. just slow down things so I am pretty happy noone says anything right now that could slow down the process to...

I am really happy for every company or research that is around hearing loss and tinnitus. God bless such researchers that focus on such a complex topic, I bet there are easier methods to make money - maybe a new fitness pill? Also failing ideas are a step in the right direction for all of us...

Of course you would be happy if it works and try to tell people but to be honest there are enough common methods in the business world to keep people quiet and it's even easier if you are a patient and really really need that drug. For example: If you say anything, they exclude you from...

They are very very rare but I think it would be dubious if an ENT would say "do it, it's not risky at all". I am pretty sure you will have to sign a paper, where you see all the risks. Like every other surgery also this surgery contains some risks. I only would look out for some ENTs that are...

We will know the side effects when the drug is on the market... Let's hope it cures hearing loss and the side effect is to cure tinnitus :) Delivery method seems to work like the intratympanic steroid injection. A needle goes through your eardrum and fills up the middle ear with the drug. After...

I only read that they use the already well established and known injection through the eardrum like the intratympanic steroid treatment for acute hearing loss. I don't know maybe the treatment might be "new" in some areas but what I heard from ENTs in middle EU it is very common in the US. In...

At the current phase they are in right now, what timeframe are we talking about until it could reach the market? 2020? 2021? I guess for non-Americans we can only get the drug if it's officially on the market. If I have any supporting cells left... please stay alive!! :)

I know its frustrating....when you have severe to profound hearing loss and Tinnitus....you already feel unlucky...if you read they might be able to restore something but you need <=50db to be able to restore it...it sounds like a bad joke...

Don't know if someone already posted that link (published 2012). Good explanation about severe/profound hearing loss in the cochlea concerning epithelium condition. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637947/ On one hand it says that severe to profound hearing loss patients are...

I wonder if you still have supporting cells when you have so called "dead regions" in your cochlea after a hearing loss.

I think to identify where hair cells died and to create a drug that can identify it is even more trickier. I think we are too far away from that.

When you believe in the theory of phantom pain and T, wouldnt hidden hearing loss with T need to be severe to profound?

Constant sound in the background, high frequency. Over it an always fast randomly changing hissing with multiple even higher frequencies. No way to distract from the hissing.

Could be possible if the documents you have to sign are only based on US law to avoid any problems if something goes wrong. Different countries, different rules. I don't know if there are any paragraphs to bypass the country of origin but could be an immense overload in the early stage.

I think it will stick everywhere around the middle ear and also at the part of the cochlea that reaches that area especially the oval window and after a while it will go into the fluid of the cochlea. The ratio between the sticky component and the active ingredient will be important - so I think...

They inject the drug into the middle ear so you need the middle ear volume. It's 1cm3 so around 1ml. It travels from the middle ear into the cochlea. If this works the same like an intratympanic cortisone injection, the middle ear will be filled nearly to the maximum and you are not allowed to...

Silence is so freaking loud!

Also if it doesn't work for everyone (like me for example) I am very thankful to live in a time where I can at least hope for cure. If it works it will be the first real treatment for hearing loss since mankind exists. Of course I hope for tinnitus too. This is the first step! We need positive...

That was of course just a naive calculation. I only used the $25k value and the 300 mil (the mentioned values) just to get a feeling for the numbers and why I believe they can't cover it in the first years. I think it will be a process that starts private first and will be integrated in health...

Let's make a simple calculation. If insurance companies and/or health care systems cover the costs: 300,000,000 x 25,000 = economic crisis

Do you have an opinion regarding 70+ dB and/or dead regions at higher frequencies concerning this treatment? That would be really interesting to me. Do you see limitations? I think they said in one email that they even assume that the nerve connects to the regrown hair cells. I am afraid of...

In my opinion that's the only way they can go ahead to measure something that is actually measurable. They would not get the huge investments or interest with focusing hidden hearing loss. They need clear results that you can see in an (from the medicine/insurances accepted) audiogram. I also...

When I had my hyperbaric oxygen therapy I was there with around 10-12 other people who had hearing loss. The people were between maybe 25-75. The old people in most cases nearly lost their hearing completely in one ear. But the funny thing was, that at the first therapy unit we talked about the...

I had that hyperbaric oxygen therapy...looked like a submarine. It was so loud that after the therapy I felt like my head will explode. Yeah I know I had to cut the lawn today...terrible...

Thanks for your input! I didnt know that many people use white noise for T. Is it really that common? I thought to stay away from any noise since I have noticeable hearing loss I really had luck not to lose my left ear completly. I am sure that there is damage to the still available frequencies...

Well I think I got T because of being busy all the time, so I am not sure right now what to say :) - two edged sword. There is of course a lot of pressure. My T reminds me now that there are also other things in life I have maybe forgotten. When there is stress and the T spikes I stand up and go...

hm should I order something to eat? a beautiful evening just T and me.

I'm self-employed since 13 years. IT business. I can take breaks if it spikes but also depends on the current workload/upcoming projects (planning) of course.

Sorry it was not clear for me that you meant yourself. I thought you meant it's off topic to say "internet wall" and "America" in one sentence. You seem to be from CA. Since your reply at the Frequency Therapeutics thread, your words in my direction have a little bit of negative connotation to...

I know it's about GDPR. It's not off topic to ask if someone can please post me the information as I can't read it. I am allowed to get the same information as everyone here no? I just mentioned that it is blocked for Europeans. Sorry if it is off-topic for you but not for other Europeans that...

I can confirm this! A few months ago there was a big story in the newspaper and TV in my country that even the insurance had to pay a T sufferer a hearing aid because of a reduction of the T while using hearing aids. Because no other treatment helped the patient went to the court against the...

Sorry that I didnt explain that earlier in detail with my hearing loss. I hear things at 4khz a little bit distorted and everything around 80db at 4khz and above very distorted. So the damage was between 4khz and 5khz and all other higher frequencies. I cant do anything with hearing aids they...

I just hear my PC fans right now nothing else. I used white noise on the university on headphones and also at work but at home I had some rain or forrest sounds but I kind of stopped it. I dont know maybe I should try them now a year after my hearing loss. I even thought at the beginning to use...

Hey there! I have T around one year now from a strong hearing loss at high frequencies - nearly deaf there - at least everything distorted at 80db. I have tried white noise before and after my hearing loss. Before I had hearing loss I tried to use it for concentration (work/study) after my...

Can someone give me a summary in 2 sentences please, don't wanna view that page with a proxy. I can't view that page because I am European?! What's going on with the US? Building internet walls? First time I see a complete website closed for EU.

It's the purpose of startups to get investments, it doesn't matter where they get the money from. What they sell is an idea, nothing else, and include that idea into some marketing and then sell a % of the company. Of course you also need some people at the front with reputation to act serious...

Well I hope so!

You think it's just another Kickstarter campaign with no product? Just really nice made explainer videos? A crypto MedCoin? or a TinniCoin? Yeah who knows... but let's try to stay positive... let's hope!