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It depends on your tinnitus loudness, pitch, and your resilience. I've had moderate tinnitus for years and it never bothered me to the point I was 99 % unaware of it.

Honestly your email sounds rude. I don't think he is going to reply. You're basically telling him that his research is a waste of time because other drugs are at a more advanced stage.

20 years of selling a scam.

Doesn't look very convincing. Anyone know the educational background of these guys?

It seems she is a member of Hough Ear Institute's staff. I've just checked on Google.

Unfortunately, this device may not work for those who have moderate or worse hearing loss at the tinnitus frequency, and for those who won't be able to find their frequency, especially if you have several tones, or hissing sounds.

It's just a theory. Cochear implants can improve tinnitus just because they restore the missing signals from the ear.

As long as they don't change the formula, it doesn't sound too bad.

The mechanism of this drug is confusing. It is supposed to prevent noise-induced hearing loss, but it can also reverse cochlear nerve damages and tinnitus.

Sounds great. Do you still use Lenire?

Any news from Dr. Jacquemin?

I'm pretty sure curing hearing loss will help tinnitus just like when we play our tinnitus frequency on our laptop, we get some very short relief because the missing signal has been restored during a small amount of time. It is just Ridder's own theory, it doesn't mean it is shared by every...

Interesting, but I don't think I have understood everything. Does it reduce distress, loudness or both?

From now, it's going to take 5 to 10 years as long as everything works.

I think you will have to use the device over and over to get permanents results. Lenire gives permanent results for those it works. However, I agree it's not a cure. Unless your tinnitus is mild, it won't disappear with this treatment but its severity may reduce. It also only works for...

rTMS seems to be less effective than rTDCS to treat tinnitus.

Hi Billie. How are you doing? Have you recovered from sudden sensorineural hearing loss?

Intensity, Duration, and Location of High-Definition Transcranial Direct Current Stimulation for Tinnitus Relief This is just one study. And the sample size is relatively small but as I said, there are other ongoing studies with larger sample sizes.

If you're interested in Dr. Shore's treatment, maybe you should consider tDCS, especially if you live in Europe as it is much less expensive there than in the US. There is a new generation of tDCS devices that have been showing promising results for tinnitus treatment. There are ongoing...

I believed that I had interstitial cystitis when I had a bladder problem last year that was actually benign. Basically, I wanted to go to the toilet every 5 minutes. My bladder also hurt when I was sitting on a chair. It was horrible, worse than tinnitus. I was so obsessed and scared that it...

I read the study. It looks good. I know there is an ongoing study using this HD-tDCS in Belgium. Maybe we will know more about it next year.

So hearing regenerative drugs are just not going to be available anytime soon. I'm really sad. I guess our best luck are Kv7.2/3 channel modulators and maybe brain stimulation to a certain extent.

Assuming FX-322 only shows minor MEASURABLE improvements but is safe, could it hit the market considering there is no existing regenerative drugs?

I've just watched this video from professor Dirk de Ridder. He says that all treatments based on electric or magnetic stimulations give positive results to 20-30 % of patients. Same for antidepressants and neuromudulation. Pretty disappointing, but this video is 5 years old. In a more recent...

If your tinnitus is mild, I wouldn't try this. There is more chance that you make it worse.

I have the same kind of fluctuations on my audiograms. An improvement of 10 dB is really not impressive.

So what may happens now? Will they continue the trial? Will they have to stop ? Edit: My bad, there are still ongoing tests for more severe hearing loss.

Do they have to start from scratch? If the drug is safe and if they reached Phase II for the migraine trial, I guess they can skip Phase I?

I read this drug's development was discontinued in 2017. It was first designed for migraine and the drug reached Phase II but it didn't show positive results.

I'm confused. I thought it would work for chronic tinnitus too. I remember that Retigabine also helped chronic tinnitus, not just acute noise induced tinnitus as this study says.

It doesn't mean you have profound hearing loss. For instance, I have moderately severe hearing loss above 8 kHz (tested multiple times) but I can't hear anything through headphones.

They haven't published their Phase 2 data yet, and we don't know what is going to happen after that. They may commercialize their drug fairly quickly. However, Xenon drug is still ahead of FX-322.

Most put all their hopes on regenerative drugs. But these drugs are still in Phase 1 and have some limitations regarding the cause and the severity of hearing loss.

XEN-496 is also expected to be more potent. This is something that Prof. Thanos Tzounopoulos should have been asked. Prof. Thanos Tzounopoulos mentioned that he wants to redesign Retigabine/Trobalt, but this is what Xenon is already doing.

Is there a chemical difference between Dr. Thanos Tzounopoulos' drug and XEN-496?

There is a confusion between habituation, and not reacting to your tinnitus. I think if you don't react to your tinnitus, but you still hear it, you have not habituated. I'm pretty sure it still bothers you. Habituation means you truly don't react to tinnitus and, as a result you don't hear it...

Listening to your tinnitus pitch softens your tinnitus for a few seconds, because the altered signal from the cochlea is momentarily restored. It proves that healing hearing loss should be enough to treat tinnitus.

I think it's normal if you can't hear anything above 16 kHz when you are 20+ years old. It might also be a hardware problem.

I haven't found any translation in English but, in another interview with English subtitles, she says that 30 % improve.

So Otonomy have now completed the first phase? I thought it was the second. The results look good but it took 3 years to complete the first phase and there are two phases left.

What do you mean by that ? Do you hear a pulsatile high pitch sound ? If you can also make it quieter by firmly clenching your jaw, then there is something you could do about it.

I read somewhere that support hair cells depletion occur in the severe range, i.e. between 70 dB and 90 dB. I'm confused. Does it mean, say 4 kHz support hair cells, could divide and fill another frequency's hair cells?

Look at the chart in the message I quote. It shows the evolution of THI for each patient. Two patients went from a THI of almost 100 to 50. It's a major improvement.

The two worst cases have improved a lot.

40 dB of hearing loss is between mild and moderate. It's not massive. My hearing loss is moderate above 7 kHz but the rest is normal, and I don't feel I have hearing problems, except when I'm surrounded by too much background noise.

I don't think so. I also have this crakling sound when i swallow. I've had it for years and I don't have ETD.

I guess this device can trigger habituation. There are different neural connections between the prefrontal cortex and the limbic brain, between those who have habituated and those who have not.

Hey, thank you for sharing your story. How loud would you say it is?

I can soften my tinnitus just by clenching my jaw. I don' t know how common this form of tinnitus is. Sometimes, my tinnitus gets pulsatile especially when I do sports, or when I stand up.

So the results are not permanent? Dr. Ross O'Neill said the opposite, he stated the benefits could last at least 12 months after the end of the treatment.

Your new hair cells may not innervate with the right nerve endings and would not grow in the right spots. Thank you for having posted their answers, @MadsWithT. The success rate is quite disappointing considering how expensive the operation is but their sample is very small and we don't have...

How much does your tinnitus fluctuate with Lenire? Susan Shore also believed that the tone of your tinnitus matters and your tinnitus has to be matched with a similar sound. However, the pitch is irrelevant according to Neuromod which confuses me.

it's neither a failure nor a success. Trolls keep saying that is a complete fail but the reality is it works for some and it doesn't for others.

You can send him an email. He often respond to his emails.

I've made my decision. I will give Lenire a try next year. There is something like 50% of success rate and there are very few cases of permanent worsening.

I'm confused. I read a few studies about flat cochlear epithelial, one says that it occurs when you have severe hearing loss (70 dB), not profound (90 dB). FX-322 trial includes subjects with mild to severe hearing loss, which means a pure tone audiometry within 26-70 dB. It sucks for those...

I don't know if TRT or CBT work, but I have hypnotherapy session which I find helpful. It doesn't reduce the volume, but it makes tinnitus more manageable, somehow. However the "benefits" don't last long, but I have to admit that I don't practice hard enough.

Lenire is different than TRT. I guess it doesn't work for many people because of the settings. There is a large range of values for the signal timing. If you have some skills in programming and in computer engineering, you could design your own device and find the right calibration. Or more...

Here is my extended audiogram. I 'm afraid that FX-322 may not fully work. I guess that the cochlear zone around 11kHz is dead.

The number of SGN remains normal, even for people who were born deaf or with severe hearing loss. I don't remember the name of the study but it was posted by FGG. It showed that even 80 something years old people with severe hearing loss/deaf still have a normal amount of SGN.