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I'm curious about BHV-2100, their drug for chronic pain disorders and if that would have any effect on noxacusis. It's still only in preclinical though.

@Nick47, I know you ran out of Gabapentin but did you manage to get a new prescription? You're writing about it as if you're currently on it so I figure you did? You mentioned in another thread that it reduced the reactivity of your tinnitus. Do you mean that it reduced the reactivity...

Fairly recent study on red and infrared laser therapy for tinnitus. It was published in March this year. → Effects of Red and Infrared Laser Therapy in Patients with Tinnitus: A Double-Blind, Clinical, Randomized Controlled Study Combining Light with Ultrasound, Drugs and Vacuum Therapy

I find it a bit odd that they are excluding somatic tinnitus since approximately 60-80% of all tinnitus sufferers have somatic components despite not having a somatic cause.

It was a couple of years ago I tried the Bose ones out but IIRC, Bose was the leading brand back then when it came to noise cancellation. I don't know about specific models but I'm sure there are lots of reviews and rank lists out there for noise-cancelling headphones that are currently on the...

Noise-cancelling headphones are generally quite good at blocking out low-frequency noise such as road noise, engines etc, but less good at high frequencies. I've tried Bose noise-cancelling headphones for car rides and they were good at blocking out low frequencies but the noise-cancelling...

Do you (or anyone else) remember if there was such a discrepancy between treatment Group 1 and Group 2 in the Phase 1 study? Though that was a study with only 20 patients so it might be harder to find such trends and patterns in there?

Then there's also the Kv3.1 which I guess some research must've shown that it's also expressed in the inner ear since Autifony's drug AUT00063, specifically for tinnitus, acted on the Kv3.1. But that turned out to be a dud and they cancelled the drug halfway through Phase 2 due to no effect. I...

But this was Phase 1. In Phase 2 the tinnitus continued to improve even after the treatment period, according to Shore's presentation from December.

When I read it fast at first I interpreted it as not having had tinnitus for more than 12 years. Looking at it again, I interpret it as there is no limit on how long you've had tinnitus as long as it hasn't been bothersome for more than 12 years. For example, you could've had it for 30...

A bit curious about this Polish study. Since it isn't invasive (you just put a thingy into the ear canal, just like you'd do with an earplug) and the results were quite impressive, wouldn't this be pretty easy to get to market?

Pimozide is not on the market here in Sweden. The last form of it (Orap 2 mg) was taken off the market in 2001. I can't find any information on why it was taken from the Swedish market though.

Why didn't they include a fourth arm with 0.3 mg in this trial?

Sound Pharmaceuticals. Here's the thread: Sound Pharmaceuticals (SPI-5557 & SPI-1005)

Not Phase 3 but this poster was in Phase 1 and 2 for Meniere's and posted about it in the Frequency Therapeutics thread. Check out his posts: https://www.tinnitustalk.com/search/member?user_id=44454

You're right, my bad. I completely missed that they were doing SPI-1005 for acute, mild to moderate NIHL too. I thought it was only for Meniere's (and now COVID-19). It's still listed on their pipeline chart and stuck between Phase 2 and 3. It's really strange it hasn't moved forward if Phase 2...

No, they presented the results from the SPI-1005 Phase 2 in June 2019 (the trial lasted between September 2017 - March 2019): Sound Pharmaceuticals announces positive topline results from the SPI-1005 Phase 2b Meniere’s Disease clinical trial According to their pipeline they are either still...

Here's one: https://hyperacusisresearch.org/low-level-laser-therapy/

This article about Prof. Thanos Tzounopoulos was posted November 9. I don't think there's anything in it we didn't know already though. A Pitt scientist is striving to quiet the ringing in veterans' ears

In Tonic Tensor Tympani Syndrome, even low volume noises can cause these rumblings, vibrations and fluttering. Especially in silence (at least for me). If I turn a page in a book in silence I get fluttering noises as a response to the sound. If I turn a page in a book while a faucet is running...

There's also a theory about inflammation that could be the explanation for this too, if I'm not mistaken.

I've always enjoyed Phil Elverum's lyrics (The Microphones, Mount Eerie etc) and the way he describes how small we are as individuals in the universe and nature's indifference towards the destiny of mankind. And not in a nihilistic depressing way but more in a sobering way. Nature (specifically...

Done!

Agreed. I was a Blur boy myself during the great war.

Could inflammation possibly be the reason behind tinnitus that fluctuates wildly? My tinnitus fluctuates a lot from day to day and is sometimes extremely reactive, while other days it's more akin to how it was when it was "normal" (before I developed severe hyperacusis and worsened tinnitus).

Before hyperacusis, I skated and was heavily invested in the culture (making skate videos, wrote for a skateboarding blog etc). I had tinnitus before I started skating and it never bothered me there and then but in hindsight, I'm actually not sure if it was that smart. It's very possible that...

For being such a scrawny fella, Jaws must have a really strong skeleton. I wonder what his knees are like, from a medical standpoint, after all that abuse. Dude is over 30 now, maybe it's time to do more low impact skating.

Nope. I'm figuring the risk of worsening is much higher than the chance of it getting better for me so I have no plans currently to do it. Even though I still sometimes wonder if my wisdom teeth could be the cause, it's quite low on my list of possible causes. So sadly I don't have any advice...

This study is very similar to the one from 2016(?) were they also measured LDLs between people with and without tinnitus. The tinnitus group had worse LDLs with a difference of approximately 11dB. I know there is a thread about that study somewhere on Tinnitus Talk but I can't find it. EDIT: I...

It can be caused by ototoxic drugs too, just like tinnitus.

I was like 11 or something when I got tinnitus so your ENT is an idiot.

Well, I have severe noxacusis (and loudness hyperacusis too) which came on gradually in late 2013/early 2014. Before that I had "normal" tinnitus which I was 200% habituated to. My tinnitus has changed a lot during these last years. It fluctuates a lot from day to day and on some days it's...

My hyperacusis came on gradually. Much like you describe about noting that kitchen sounds bothered you, I had the same problem but with certain people's voices at parties and taking showers in the morning like a year before it got real bad. I never thought much of it in those days. When it did...

Exactly. I don't know how you had it. Just as you don't know how me or other people have it. And as the research into "hyperacusis" stands today, it doesn't exist. So don't make assumptions. That's my whole point. You can give support without toxic positivity, it's entirely positive. Just don't...

But no one is saying that. Every case of hyperacusis on here is different since "hyperacusis" dosen't exist anymore. Some people obviously get better. But they probably had another pathology to begin with than the "horror stories" like me and some other folks on here. Saying "it will get better"...

Michael never describes his stint with hyperacusis in other words than with these exact words, time and time again. That's quite odd. It's also odd that he calls it severe when what he describes sounds more like mild borderline moderate according to Jastreboff's chart. Michael has never once...

This was posted yesterday (November 2). Decibel Therapeutics Announces Exclusive Licensing Agreements for Hearing Loss Gene Therapy Technology https://www.decibeltx.com/decibel-therapeutics-announces-exclusive-licensing-agreements-for-hearing-loss-gene-therapy-technology/

Agreed. However, I can't place him on ignore. I feel like I have an obligation to newcomers to call him out on his bullshit every once in a while. He on the other hand, has obviously placed me on ignore since he couldn't provide any actual arguments besides his usual ad hominem strategy.

Would you tell someone suffering from terminal cancer not to post in a support group for cancer patients too? Please think a little longer before writing such hurtful comments.

But Tinnitus Talk is a science based support forum.

Off topic, but could you point me to one that is highly absorbable and not just a laxative? I just started taking magnesium and this stuff was pretty damn expensive and had good reviews so I'm hoping it's just not a laxative :clown:

Yes, it's probably brain related and more like misophonia. I don't think they have sound amplification in the same sense as us hyperacusis sufferers and I wouldn't call it supersonic hearing either. I think it's more about a processing and filtering based problem in the brain where the brain is...

I very much doubt it. The sound sensitivity/sensory overload among autists is very different from hyperacusis due to physically damaged ears. I'd say it's closer to misophonia which also has nothing to do with damaged hearing.

Yes, that was my point. I was just theorizing if the new findings that "age related hearing loss" doesn't exist but has the same cause as the types they're testing for now could be the reason for the new trial.

That would go against the latest research findings that age related hearing loss actually is the same type of hearing loss as from loud music or ototoxic meds. Maybe it's because of these new findings they started this other trial?

You mean this one? https://www.frontiersin.org/articles/10.3389/fnins.2020.561185/full It looked at tinnitus/hyperacusis and not hearing loss I think.

Wondering the same thing. Google only gives me stuff about George W. Bush's views on stem cells.

From October 6. Investigating the Interaction of Auditory and Pain Pathways https://hearinghealthfoundation.org/blogs/investigating-the-interaction-of-auditory-and-pain-pathways

https://hyperacusisfocus.org/ https://hyperacusisresearch.org/ These are very valuable sites and have links to a lot of important papers.

1. I wish they knew more about hyperacusis/noxacusis and kept up with the research about it instead of being stuck in the Jastreboff microcosmos from the 90's. 2. I wish they knew more about tinnitus and kept up with the research about it instead of being stuck in the Jastreboff microcosmos from...

Based @Contrast taking down those scammers. The hero we need but don't deserve etc.

I haven't had much interest in Sound Pharma since that drug is for menieres but this info has has piqued my interest. This may be a stupid question but is there any chance it would also help with potential inflammation in the middle ear?

Looks like the bolts Frankenstein used on his monster.

Don't forget Prof. Richard Salvi's theory that everyone with T actually also have H but most of them have it in such a mild form that they aren't even aware of it (I can't be arsed to find the source where he says this, sorry). In hindsight, I think this was my case between 1999 and 2014. There...

On this page there's a video with a patient testimony. She got tinnitus from bullous myringitis. https://www.flareaudio.com/pages/calmer-life

Got this sent to me by friend recently too. It doesn't sound as a scam since it was a surprise to them that tinnitus got better for some people. The product was developed for something else entirely, although I'm not quite sure I understand exactly what this product does. On the other hand...

When it comes to hyperacusis this is basically the opposite of what Michael says and that's what's bugging me. According to Michael's posts, there's a one-fits-all solution for hyperacusis (TRT/sound therapy) and if it doesn't work, it's because of your negative thinking. He refuses to realize...

Yup, it's for hidden hearing loss/synapse repair.

This is in no way an answer to anything I wrote but ok. You can give her support without being rude towards patients who didn't respond to sound therapy/TRT. You've been warned before by the admins about patient blaming and posing as an authority on T and H. Please have the courtesy and respect...