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Auricle is a dead horse now. Beyond science, Pearson's incompetence will make it explode. It's a succession of red flags without the slightest positive sign. Even if he manages to bring it to market in several years, there will likely be better treatments available by then, or the patent will...

In the pharmaceutical world, tinnitus doesn't seem to rhyme with "gold mine;" in my opinion, it's quite the opposite. Very few conditions are more cheesy and despised than tinnitus.

The skepticism is mainly directed at Auricle's supposed inability to market this product effectively.

You forgot the story of people turning blue (irony). Trobalt was not the poison some people would have you believe. Definitely a drug with too many side effects, I agree. And XEN1101 will in all probability have side effects of the same nature, although attenuated.

I think that instead of making assumptions (positive or negative), it would be more helpful if everyone consulted Dr. Shore's patent.

In Dr. Shore's paper, timing is parameter #1. Lenire is based on a different theory I know, but where Dr. Shore's papers are well constructed, Lenire's are enigmatic. In my opinion, using a Bluetooth system in such sensitive device is an unnecessary source of complexity, to favor the...

Lenire uses a Bluetooth system, which is a disaster for a system where the timing must be precise to a millisecond range. This unnecessarily complicated design makes Lenire closer to a teleshopping gadget than a medical device. Comparing Lenire with real bimodal treatment devices makes no sense.

Of course it's your choice, but Lidocaine alone does not have much benefit beyond what we know. Personally, I have never had any problems with Gabapentin, even at high doses. Maybe consider low starting doses? It's a real chance to have such an understanding and competent ENT.

Is there evidence that the GABA activity of Retigabine is a different mechanism from other drugs that act on this neurotransmitter?

To put it simply, yes, I got an objective reduction with Retigabine, because I simply no longer heard my somatic tinnitus, like 0.

Yes, I use it in "Aspirin mode" for now, but I plan soon to start a 3 x 400 mg/day treatment for 2 months.

Our greatest fear is that the selectivity of XEN1101 doesn't activate a channel necessary for tinnitus suppression. I'm of course thinking of Kv7.4 which is present in the auditory pathway. Maybe I'm misinterpreting, but from what I understood from these two papers: XEN1101 Retigabine...

If I recall correctly, in the patent.

No, the stimulation is not more important than the sound. In fact, according to the papers, the stimulation part alone tends to temporarily worsen tinnitus. To put it simply, this technology consists of stimulating neurons via somatic stimulation and sound, almost simultaneously, but with a...

So I imagine you were receiving a shallow injection into the skin of the ear canal? Do you remember how long your ear was anesthetized after the injection?

I guess it will take another year after the FDA decision to think about what to do, and waiting another year to start thinking about production after. I respect Dr. Shore's work but I come to think that the best way for her technology to come out, is to have it stolen by the Chinese who don't...

It would not be a surprise for me if a relatively effective path remained forgotten. I remember the total immobility of tinnitus sufferers during the Team Trobalt era. Gabapentin and Lidocaine represent some interest. But I don't really understand, it's an intradermal injection but in the...

Apart from the tolerance which can develop over time, like a lot of drugs, the random effects of Retigabine must be able to be explained in my opinion. I noticed huge disparities depending on whether I was fed or not, but also on my physical activities. I hope XEN1101 will be more reliable in...

This effect on smooth muscles may be the cause of certain side effects of Retigabine. Particularly on urinary retention and cardiac “disorders”. So, if I recall correctly, it's a channel that reformulations avoid. According to Professor Tzounopoulos, Kv7.2/3 are clearly the induction...

Interesting. This may be one of the explanations for why Retigabine doesn't work for everyone. But according to the anecdotes we have, it's mainly, in my opinion, a difference in generation site. A good % of people benefit from Retigabine, at least a little, which indicates that their Kv7...

These heavy side effects were also associated with Gabapentin and my emotional state so it's hard to be sure. I prefer to warn when in the doubt. It's also quite comparable to acids/hallucinogens, the risk of "bad trip" and psychosis is mainly linked to your emotional state. That's what I felt...

Yes, this has always been the case so far, from almost nothing to heavy side effects. Most of the time it is a state comparable to alcohol psychologically, but without the effects of nausea and such. And it's very selective. For example, I have a lot of trouble organizing my thoughts, but not...

Both. In January I took it x3/day for 2 weeks; it worked only 2 times. I adopted an Aspirin approach, x2-3 per week in the month of May; 100% of success. In August I tried x3 per day for 1 month; most doses worked but it was pretty random. I recommend taking it on an empty stomach. The...

300 mg and 400 mg. It's very random, sometimes 300 mg works better than 400 mg etc, but under 300 mg there are no effects at all. Side effects are pretty heavy but manageable. Yes, not very convenient. My best hope with Retigabine is to get definitive effects with a cure of 3 months max. In...

Indeed. I got tinnitus in August 2020. I started first Retigabine experiment in January 2023 but without real success. My first success is in May 2023 and my best treatment session is in August 2023, so 3 years after onset.

I got my tinnitus 3 years ago, so it seems to work for chronic cases.

It helped my somatic tinnitus, yes, it 90% vanished for 1 hour. It probably did something for the non-somatic tinnitus, but far less than for my somatic tinnitus. But I remember I was one day basically tinnitus-free for 1 hour, i.e. impossible to hear it unless being in perfectly silent room.

May I ask what was your dosage?

I asked to Dr. Shore 4 months ago if my case (noise trauma, 50% somatic and 50% non-somatic tinnitus) could benefit from this technology. She said as long as I have somatic tinnitus, the non-somatic part could benefit from it. I read her patents/papers and I wasn't able to find the point that...

From my experience, Retigabine tablets are not divisible in themselves, but with a scalpel and a small precision scale you can do it with an acceptable margin of error.

And some money consideration, to be honest. Again, Retigabine indeed has heavy side effects but these mainly concerned high doses in the long-term. It's not poison. A reformulation halving the side effects would be, in my opinion, already acceptable.

@StoneInFocus, you can criticize my intelligence and my English if you want, but apart from proving that you have nothing left to say except personal attacks, it won't change your incoherent speech. And, obviously, your opinion is only shared by you. To conclude, I would say that this is a bit...

There's nothing to respond to someone who only contradicts for fun. I agree for the rest.

Of course, there is no evidence that XEN1101 is a superior remake of Retigabine, that's our hope, it's consistent, but it's not proven. I remind those who speak of the mythical effectiveness of Retigabine that the molecule, without being a miracle cure, has shown effectiveness at some point...

It's especially the desire to converse with you that I miss, you only question dominant theories by raising non-questions, with a quite clumsy scientific rigor to be honest. You are asking me to prove that Retigabine, which is a Kv7 opener specifically designated for this, in particular Kv7.2...

Dude, I'm not changing the subject at all. I don't know what you're trying to say, it's pretty well documented here that Kv7.2 and Kv7.3 are suspected to be the source of some cases of tinnitus, more than any other channel. But other mechanisms are possible of course, that's all my doubt...

Precisely because Retigabine is a Kv7 opener and Gabapentin is not, at least much less so.

Well, in most of the papers I've read about Kv7s and tinnitus, there's rarely any mention of channels other than Kv7.2 and Kv7.3. If you have papers which explore the application of other channels in tinnitus (and not in hair cells), I'm interested. For what it's worth, if I recall correctly...

Let's say I did more than just theorize. Besides the hundreds of papers on the auditory system, experiments (including Trobalt for example, but not limited to) and random events have enabled me to determine where my tinnitus generation site is. There remains a small doubt, the inferior...

That's exactly the point. I don't have an answer, I just know that according to the dominant theory Kv7.2 and Kv7.3 are "enough". K7.4 is indeed expressed in the hair cells. In my case I am 95% sure that the tinnitus affected by Trobalt is not located in the hair cells but in the DCN. It is...

In my case, Gabapentin is incredibly weaker in terms of efficacy on tinnitus than Retigabine (Trobalt), although I think they make a good combo. The real question is can XEN1101/BHV-7000 activate the channels responsible for tinnitus. If they do the same as Retigabine, they will indeed be very...

No I don't have any hyperacusis/noxacusis, I can't do any statement about that.

Well, I don't know if it fits in the charter, but Trobalt by far. I was lucky enough to get some stock from someone who kept it in a freezer. Trobalt works, but is far from a miracle treatment since it's pretty unstable. However, the next generation Kv7 openers, in the event that their action...

Kv7 openers. It's far from a miracle but it's the only thing in 3 years of tinnitus that has objectively destroyed my tinnitus temporarily.

Well, is it temporarily? Does this concern all tinnitus or just one tone? What is the dosage/effectiveness ratio? That kind of stuff, but don't feel you have to answer That this dose is, according to what I know, below the threshold of effectiveness for this drug, so I'm curious how you can get...

It's a very vague answer. Anyway, happy for you.

I used Gabapentin with a Kv7 opener. From what I understand in my case (related to hearing loss), tinnitus is largely a central problem, maybe even totally. My opinion is that whatever you try, the main problem is to obtain definitive results. That's why, in addition to drugs/technologies that...

You scale at microdoses guys, I find it hard to see how such a low dose can have any effect, I hope it's not a placebo. Here the ENTs prescribe you up to 3x 100 mg. And by their own admission, at this dose it's more of a placebo than an active drug, they don't want to take the risk of...

Can you tell me where you see that people with non-somatic tinnitus can also get a benefit, please?

First, you didn't understand what I meant, I'm simply saying that there is a huge interest in knowing how far her device can act in the auditory system. You would have to read her research to understand that. And I remember the big announcement you made about Xenon Pharmaceuticals. Just wind...

There is currently no evidence of the extent to which this treatment is effective, and I speak from experience. It seems obvious that it works for at least one subgroup, but no conclusions can be drawn from this. It's not known how far this device can reach the site of generation of tinnitus...

For a so-called scientist, I noticed that you are very approximate in your interventions. Like when you claimed FX-345 was the same formulation as FX-322, which is wrong, and easily verifiable. Thank you for using the conditional, you don't know more than another (although I share the...

Can you tell me where you got this information please? And indeed, this corresponds to the electrical impulse.