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It's been a while since I have shared any pharma news here on the forum, but today, Otonomy held its Q1 2019 conference call on the results for the period while providing a business update at the same time. The update was designed so as to have a special focus on OTO-313 (a treatment for...

An article by the Daily Mail has shed light on gender differences when it comes to those suffering from severe tinnitus. A Swedish survey – which is the basis for the article – found that women who suffer from severe tinnitus are at increased risk of attempting suicide (compared with men). The...

As the title indicates, a recent publication suggests a possible link (cause) between certain antidepressants and dementia. A causal relationship hasn't been proven due to the study design, so it remains a correlation at this point. The report has been noted by several of the major media...

An article covering the story behind the All Ears campaign was featured in The Independent a few days ago. The article points out concepts such as "vanity" and "sound distortion" as reasons for people not using earplugs at gigs or nightclubs. The type of earplugs being sold by the All Ears...

An article by The Economist states that Americans spend three billion dollars (annually) on homeopathic medicine (which is proven to be ineffective). Yet... as an interesting comparison, the ATA has revenues (per year) just above one million dollars (or 3,000 times less). So... in a nutshell...

Today, Otonomy did a live presentation at the JP Morgan Healthcare Conference which served to update the market on what's to come in the year ahead. The presentation deck has received its largest overhaul to date and the slide containing the pipeline now looks like this: The main points of...

"The day will come when man will have to fight noise as inexorably as cholera and the plague." –Robert Koch, Nobel Prize-winning bacteriologist In 1905, Robert Koch made the above statement - and - it turns out he may well be right. In the past couple of days, two articles were published that...

The following article... www.inverse.com/article/34744-headphones-aren-t-making-teens-deaf ...was based on a newly released research paper on trends related to hearing loss in adolescents. However, the article apparently refers to the wrong study via the embedded link...

Newly published research in the prestigious journal "The Lancet" examines the factors contributing to the development of dementia. The researchers split the contributing factors into modifiable and non-modifiable causes. Of the modifiable causes (which accounted for 35% overall), hearing loss...

An editorial from 2017 concerning statistics on tinnitus and hearing loss has been published in the journal Elsevier. Since facts and figures indicating prevalence can be hard to obtain due to information being paywalled, hereby the graph showing disability awards for the US veterans population...

New Research Topic For those interested, there is a new research topic launching this year: http://journal.frontiersin.org/researchtopic/6420/hair-cells-from-molecules-to-function The research topic is similar to the so far highly successful research topic on tinnitus...

Smoking during pregnancy is well known to cause babies to be born with low birth weight as well as having a higher risk of complications during pregnancy. There are many other documented impacts - as any mother would have been briefed on during consultations and screenings with healthcare...

With more than 2,000 posts on TinnitusTalk, the average visitor will eventually have stumbled upon one of my posts here on the forum. I shall therefore not spend too much time on my background. But briefly: back in 2013 (April), I developed severe, unrelenting, and multi-tonal tinnitus. Within...

New study on LSD. http://edition.cnn.com/2016/04/12/health/lsd-brain-imaging/index.html http://www.nature.com/news/brain-scans-reveal-how-lsd-affects-consciousness-1.19727

Since about a year and a half, the involvement of certain Kv7-channels in relation to the induction of tinnitus, has been closely followed by a large number of members of TinnitusTalk. Retigabine is known to target this set of Kv-channels (with the addition of Kv7.4/5). The potential for...

It's been 20 years since the accident took place. Despite no deaths, it ranks as one of the most horrific accidents ever in the history of skiing. The accident forced skier, Tatyana Lebedeva, into early retirement.

If you watch closely at the very beginning, it is clear she is not having any earplugs in. Then watch what the bass does to her hair... [Mind the volume if you are using headsets...] The human race is such an intelligent species. Sigh. (Probably the chick is now a member of TT).

+1 to the rescue efforts of the instructor at 2:33

A group of members on TinnitusTalk have asked me to write a message of awareness on the pre-clinical trial compound SF0034 - a compound by SciFluor Life Sciences and which may have the ability to treat tinnitus. In order to write such a message of awareness, I will need to go back to around this...

Many of us are aware of Auris Medical's AM-101 programme which aims to treat acute inner ear tinnitus. Perhaps less well known at TinnitusTalk is a 2nd clinical trial programme from Auris Medical which aims to treat acute inner ear hearing loss. We have recently been in touch with Mr. Meyer (CEO...

Auris Medical has just released financial information on their company for the 3rd quarter. The update includes a summary on their clinical trial programme. As always, it is well worth a read. http://ir.aurismedical.com/phoenix.zhtml?c=253572&p=irol-newsArticle&ID=2111740

Dear worldwide tinnitus community, In the past few days, and after the failure of the QUIET-1 study, there has been an attempt to increase awareness of the work of the scientists behind the following paper on four different potassium channel openers - one of which is Trobalt/Retigabine...

Show Your Support For Tinnitus Researchers One of the reasons why certain medical conditions take a long time to understand, research, and cure is the lack of a governing body that coordinates the work among researchers on a global level. The tinnitus community, however, is fortunate to have an...

The 9th TRI Tinnitus Conference titled "TINNITUS: FROM COCHLEA TO BRAIN AND BACK" will go ahead beginning tomorrow. It will finish June 10th. The full programme overview along with invited speakers can be found in the pdf-file attachment. attheedgeofscience 06/JUN/2015. Source...

As members of this forum may know we, @Team Trobalt, are tracking down information on pharmaceuticals involved in potassium channel modulator research. Knopp Biosciences is (probably) another pharmaceutical that most people are not aware of. However, tinnitus is actually mentioned (briefly) on...

The following very recent finding from an animal model may have implications for Trobalt and its therapeutic potential on the treatment of symptoms of tinnitus. I will try to find out more.

An interesting resource on ion channels. http://channelpedia.epfl.ch/ionchannels/188

http://www.ncbi.nlm.nih.gov/pubmed/25796568

For those interested in potassium channel modulator research...

Minor update on OTO-311... I will try to get hold of some kind of information as to why the next step will be a phase I trial (and not a phase II trial) given that an initial trial had been conducted by another company already (i.e. "NeuroSystec"). I will also try to find out if the phase I...

This will be the "official" TinnitusTalk kick-off thread for AM-102. After a fair bit of research via financial sources I am able to at least shed a little light on what the so-far undisclosed compound of Auris Medical's secret AM-102 tinnitus "weapon" might be. The addition of two new drugs to...

The links below are from a newsletter I just received in my inbox. I will track down the details of the treatment to the best of my ability; I am surprised at the news (although I have had a few heads-ups recently), but I am fairly confident the organization in question would not post the...

Enrollment information for the phase II trial is now available on the Autifony website: http://www.autifony.com/autifony-tinnitus-quiet-study.asp Good luck to all. From the staff of Tinnitus Talk on October 13th, 2015: Autifony's QUIET-1 study has been terminated due to lack of efficacy...

Day 0 — This will be the very first entry regarding my stem cell treatment for tinnitus (for those who are interested in following the 2 week treatment course). I arrived all in one piece this morning local time in Bangkok. The trip from Germany went via Istanbul (Turkish Airlines). I managed...

Let me say straight away: I am not the forum type-of-person... :) However, having spent a fair bit of time (and money) researching possible solutions to tinnitus, I thought I'd join this forum (as it is one of the better ones, I think) to share what I have learnt about tinnitus up until now (in...