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Efficacy and safety of single and repeated selurampanel dosing for 2 weeks in patients with chronic subjective tinnitus Abstract To evaluate efficacy and safety of BGG492 (selurampanel; an orally active, competitive AMPA glutamate receptor antagonist) in patients with moderate-to-catastrophic...

Impact of Acamprosate on Chronic Tinnitus: A Randomized-Controlled Trial Objectives: Tinnitus is a common and distressing otologic symptom, with various probable pathophysiologic mechanisms, such as an imbalance between excitatory and inhibitory mechanisms. Acamprosate, generally used to treat...

Interesting. Has anyone got any experience with Gliatilin here on Tinnitus Talk? The results of treatment of 38 patients suffering from sensorineural hearing loss with the Gliatilin (solution 3 ml intravenously for 10 days, capsules 400 mg 3 times a day or solution for ingestion 600 mg 2 times...

Today (9th January 2020), the charity Action on Hearing Loss and Medicines Discovery Catapult announce the launch of the Hearing Medicines Discovery Syndicate, a unique collaboration to accelerate the much-needed development of treatments for hearing loss and tinnitus. Hearing loss affects...

Abstract INTRODUCTION: Tinnitus is defined as the perception of sound without its actual presence in the environment. It has been the subject of a great number of studies, especially considering its consequences on patient's quality of life. OBJECTIVE: This study aimed to investigate the effect...

Auris Medical Provides Update on Tinnitus Drug Development Strategy April 25, 2019 at 9:00 AM EDT Hamilton, Bermuda, April 25, 2019 (GLOBE NEWSWIRE) -- Auris Medical Holding Ltd. (NASDAQ: EARS), a clinical-stage company dedicated to developing therapeutics that address important unmet medical...

Association of Chocolate Consumption with Hearing Loss and Tinnitus in Middle-Aged People Based on the Korean National Health and Nutrition Examination Survey 2012⁻2013. Abstract Chocolate, which is produced from cocoa, exerts antioxidant and anti-inflammatory effects that ameliorate...

Water-Soluble Coenzyme Q10 in Chronic Hearing Loss https://doi.org/10.1177/0194599811416318a202 Abstract Objective: Q-TER is a multicomposite water-soluble formulation of CoQ10; in particular, Q-TER consists of a mixture of maltodextrin, acting as a carrier, of CoQ10 molecules of sucrester...

Adapted Acoustic CR Neuromodulation in Patients With Chronic Tonal Tinnitus and Hearing Loss. Chronic tonal tinnitus is often accompanied by sensorineural hearing loss which is associated with altered tuning curves and bandwidth of alternating masking. In this feasibility study the so-called...

Totally Implantable Active Middle Ear Implant: Hearing and Safety Results in a Large Series

An abnormal brain activity pattern could be a common link between Parkinson’s disease, neuropathic pain, tinnitus, and depression, an international research team suggests. The brainwave abnormality is similar in all these disorders but occurs in different regions of the brain. This discovery...

Connecting hearing helper molecules to the ear bone “Bisphosphonate-Linked TrkB Agonist: Cochlea-Targeted Delivery of a Neurotrophic Agent as a Strategy for the Treatment of Hearing Loss” Bioconjugate Chemistry Hearing loss is a common affliction associated with advancing age and exposure to...

Abstract The auditory temporal processing deficits associated with age-dependent hearing decline have been increasingly attributed to issues beyond peripheral hearing loss. Age-related hearing loss (ARHL), also known as presbycusis, is linked with changes in the expression of both excitatory and...

Comparison of Melatonin and Sertraline Therapies on Tinnitus: A Randomized Clinical Trial. Abstract BACKGROUND: Tinnitus is the perception of noise or ringing without external acoustic stimulants which affects almost 10% of general population. Many therapies have been recommended including...

Green tea effects on cognition, mood and human brain function: A systematic review. Abstract BACKGROUND: Green tea (Camellia sinensis) is a beverage consumed for thousands of years. Numerous claims about the benefits of its consumption were stated and investigated. As green tea is experiencing...

What's the difference between noise-induced tinnitus and tinnitus due to age related hearing loss? Or is it just the same?

Objectives In tinnitus rTMS treatment, the inhibitory 1 Hz stimulation is commonly delivered to left auditory cortex and/or left temporoparietal junction (TPJ). We aimed to improve rTMS-targeting with fMRI measurements. Methods A patient with whiplash and head trauma originated brain injury...

Hi people, I found this on the web. http://www.audiologyonline.com/articles/treatment-tinnitus-using-customized-ultrasonic-18261 Results: Highly significant reduction in tinnitus loudness and annoyance was observed in all subjects during exposure to a customized acoustic stimulus delivered...

Here is my theory about dopamine: Sulpiride is an dopamine angonist. It lowers your level of dopamine. https://www.ncbi.nlm.nih.gov/pubmed/17942035 Pramipexole is a dopamine agonist. It raises your dopamine level. https://www.ncbi.nlm.nih.gov/pubmed/?term=pramipexole+tinnitus Aripiprazole is...

INTRODUCTION: One of the treatments currently available for the remission of tinnitus, when associated with hearing loss is the use of hearing aids with sound generator. Such treatment is based on the capability that the human brain has to get used to a new sound over another. OBJECTIVE: To...

I smoke almost for 20 years. Four years ago my ears starts hissing. I went to the doctor and noticed a hearing loss of 60 dB ! If I stop smoking is it possible that my tinnitus goes on a holiday!? My dad and his dad has also hearing loss but no tinnitus!

A doctor in Belgium wants to put me on Deanxit! It's not available in the Netherlands. Has anyone got experience with this med?

What can I expect if my hearing is getting worse over time? Can tinnitus become louder? What medicine or supplements can I take to lower the tinnitus?

The first week I was on Amitriptyline I noticed no change in my T. Now this is the second week and my T is way up! Should I stop or continue? I know Amitriptyline has to build up in your system but I am terrified that the T stays at this level!

I just visited my doctor for my severe tinnitus. He suggested Amitriptyline because he thinks that tinnitus is some form of neuropathic pain. Anyone had some results with Amitriptyline?

I have read a lot of publications about tinnitus but what I don't understand is people with tinnitus do they need more or less dopamine to lower their tinnitus?

In my opinion it is a dopamine activator. Too low dopamine can cause tinnitus (?) I wanna give it a try ... Anyone already tried this stuff?

Can tinnitus that is related to age related hearing loss disappear? My tinnitus is two years old and so is my hearing loss! Which supplements are recommended for this form of tinnitus? Are here members that has T from presbyacusis (age-related hearing loss)? And what does it do for tinnitus...

Hi, I have had tinnitus for almost two years. Over the last month it has been worsening. I've taken Paxil for 16 years. My doctor said to cut down on Paxil as maybe it will stop the tinnitus. But my tinnitus is not even 16 years old, I've had it for only 2 years! What should I do? Stop taking...

Hi all, Living with tinnitus for the last two years. Only hearing the T in the evening and in bed. But the last month it is becoming worse. I hear it all day..... I think that i have got T because of aging (?) An audiogram taken by the ENT has learned that I have mild hearing loss. The last...