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→ 3rd Inner Ear Disorders Therapeutics Summit Participants include Acousia Therapeutics, Akouous, Spiral Therapeutics, Astellas, Ting Therapeutics, Sensorion and AudioCure Pharma. Seems a lot of early stage, pre-clinical companies attending. I will report if some more information or summaries...

AudioCure Pharma develops novel pharmaceutical therapies for the prevention and treatment of a range of hearing impairments with high, unmet medical need. Our lead candidate is a novel molecule named AC102. Phase 2 clinical trial has been ongoing for ~1 year. A Study to Evaluate the Efficacy...

The largest research conference in Otolaryngology will take place on February 11-15, 2023: → the 46th Annual MidWinter Meeting of Association for Research in Otolaryngology (ARO). It is a 4-day event with a ton of new publications and results. I separately posted → some results of Acousia...

In the last Xenon Pharmaceuticals conference call they named BHV-7000 a direct competitor for XEN1101. BHV-7000 is a reformulated, more potent version of Trobalt/Retigabine. Pfizer acquired Biohaven which brings big pharma to this development space. BHV-7000 is currently in Phase 1 but is...

It's been relatively quiet in research news after the research boom of spring. This is a new publication on hyperacusis which is rare. Unfortunately there was no link found of a somatic component to hyperacusis. Pilot study on the role of somatic modulation in hyperacusis Abstract...

U.S. FDA approves Fennec's hearing loss therapy This pharmaceutical, Pedmark, is now FFA approved for Cisplatin/chemo-induced hearing loss for ages 0-18 years old. I have no insights whether Pedmark is otoprotective for adults and for other medications besides Cisplatin. I theorize it should...

Pimozide: Treatment for Post Acute COVID-19 Syndrome A new clinical trial will start. I'm not sure what the difference in pathology between COVID-19 tinnitus and other tinnitus is. There is some hypothesis published earlier that dopamine modulators can influence tinnitus. Tinnitus...

OK, a mobile phone app, there are a dozen already, but wait, look at the results... Breakthrough in Search for Tinnitus Cure At 12 weeks an TFI reduction of 16 points, placebo controlled. Average TFI before starting was 60. This is not just cognitive behavioral therapy or habituation: A...

Abstract High-intensity sound or blast-induced hearing impairment is a common injury for Service members. Epidemiology studies revealed that the blast-induced hearing loss is associated with the traumatic brain injury (TBI), but the mechanisms of the formation and prevention of auditory...

After a permanent worsening of my tinnitus after having a small cavity drilled in December, I looked for a laser dentist. I have interproximal cavities (or class II caries) - cavities between the teeth. The Fotona Lightwalker laser is able to drill cavities between teeth, deeper cavities as...

Assessment of in-cabin noise of wide-body aircraft This article shows decibel readings of major airplanes: Airbus A330-300ER, A350-900, A380–800, Boeing B777-200ER and B787-900. Measurements were taken on three different flights on each of the planes. Not directly related to tinnitus but this...

Assessment of Subjective Tinnitus Treatment Results Using a Prototype Device for Electrical and Magnetic Stimulation of the Ear-Preliminary Study Background: The aim of the study was to evaluate the effectiveness of subjective tinnitus treatment in patients with cochlear sensorineural hearing...

Using Extracochlear Multichannel Electrical Stimulation to Relieve Tinnitus and Reverse Tinnitus-Related Auditory-Somatosensory Plasticity in the Cochlear Nucleus Objectives Tinnitus has no reliable cure but may be significantly relieved by the usage of cochlear implants. However, not all...

Safety and Tolerability Study of Daily Dosing Rimegepant in Episodic Migraine Prevention I came across this study. This medication has been proven efficient for migraines and for sound sensitivity which is part of migraine attacks. The medicine is already EMA/FDA approved. The Phase IV study...

Behavioral and Immunohistochemical Evidence for Suppressive Effects of Goshajinkigan on Salicylate-Induced Tinnitus in Rats Abstract Many people are affected by tinnitus, a sensation of ringing in the ear despite the absence of external sound. Goshajinkigan (GJG) is one of the formulations of...

This study recently caught my eye for Eustachian Tube Dysfunction (ETD) and I wonder if anyone has already tried XHANCE (Fluticasone Propionate)? It has been FDA approved and is available on the market as we speak. Because of the novel delivery mechanism the Fluticasone goes much deeper towards...

Another epilepsy/pain/depression drug which can potentially relieve tinnitus. RespireRx Pharmaceuticals highlights experimental data suggesting its GABAkine KRM-II-81 could be game-changing for tinnitus patients RespireRx Pharmaceuticals Inc has announced that members of the company’s...

I'm aware of avoiding the ultrasonic cleaner, but I'm in need of a polish which is usually done after manual cleaning the teeth. What is the consensus here? Let the teeth become yellow or can we polish them? My tinnitus spread from being unilateral to bilateral after my last dentist visit so...