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Neuropharmacology. 2018 May 1;133:319-333. doi: 10.1016/j.neuropharm.2018.02.004. Epub 2018 Feb 5. Kv3 K+ currents contribute to spike-timing in dorsal cochlear nucleus principal cells. Olsen T1, Capurro A1, Pilati N2, Large CH3, Hamann M4. Author information Abstract Exposure to loud sound...

Sci Rep. 2017 Dec 13;7(1):17496. doi: 10.1038/s41598-017-17406-x. Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage. Chambers AR1,2, Pilati N3, Balaram P1,4, Large CH3, Kaczmarek LK5, Polley DB6,7. Higher stages of...

Official Journal of the Neurootological and Equilibriometric Society Official Journal of the Brazil Federal District Otorhinolaryngologist Society http://www.tinnitusjournal.com/

"Safranal also attenuated the acute experimental absence seizures which was attributed to modifications of benzodiazepine binding sites of GABAAreceptor complex" "Safranal is an effective anticonvulsant shown to act as an agonist at GABAA receptors.[1][2] Safranal also exhibits high antioxidant...

Don't want to go deaf? Have a pint of Guinness each day: High levels of iron helps to prevent hearing loss, study finds Up to 30% of the world's population are anaemic - mainly due to a lack of iron But research has found a link between iron deficiency anaemia and hearing loss Scientists hope...

J Int Adv Otol. 2016 Aug;12(2):170-176. doi: 10.5152/iao.2016.2682. Effect of a 4-Week Treatment with Cilostazol in Patients with Chronic Tinnitus: A Randomized, Prospective, Placebo-controlled, Double-blind, Pilot Study. Abstract OBJECTIVE: The aim of this prospective, double-blind...

Women who take paracetamol and ibuprofen risk going DEAF - and all it takes is just 2 pills a week, study finds Taking two pills a week for more than six years has been linked with hearing loss The drugs are thought to cut blood supply to the inner ear and expose it to noise And painkillers are...

"Summary: Researchers have, for the first time, linked symptoms of difficulty understanding speech in noisy environments with evidence of cochlear synaptopathy, a condition known as 'hidden hearing loss,' in college-age human subjects with normal hearing sensitivity." Researchers from...

Laboratory tests found the fragrance and its chemical substitute dramatically calmed mice when their cage was filled with it, causing them to cease all activity and sit quietly in a corner. When the air was breathed in the scent molecules went from the lungs into the blood and were then...

"Bacopa monnieri (L), belonging to the Scrophulariaceae family and commonly known as Brahmi, is well known in India for its CNS activity but its neuropharmacological effect has not yet been explored. In the present study, the antiepileptic effects of the plant were investigated. The ethanolic...

Published online 2013 Aug 21 NMDA receptor (NMDA-R) is an important molecular entity governing a wide range of functions in the central nervous system. For example, the NMDA-R is involved in memory and cognition, and impairment of both (as in Alzheimer’s Disease) is attributed to NMDA-mediated...

New NMDA Receptor (Glutamate) Modulators For Depression "Glutamate modulating drugs are of interest for a number of diseases in addition to ALS, such as Alzheimer’s disease, Rett syndrome, dementia, dystonia, tinnitus, anxiety disorders, and affective disorders." "Scientists and mental health...

Auris Medical on Track to Resume Enrollment of Keyzilen™ Tinnitus Program Following Regulatory Feedback ZUG, Switzerland, Dec. 06, 2016 (GLOBE NEWSWIRE) -- Auris Medical Holding AG (NASDAQ:EARS), a clinical-stage company dedicated to developing therapeutics that address important unmet medical...

"Summary: A bioactive compound found in turmeric promotes stem cell proliferation and differentiation in the brain, reveals new research. The findings suggest aromatic turmerone could be a future drug candidate for treating neurological disorders, such as stroke and Alzheimer's disease." "A...

New approach could revolutionize treatment A new study has identified promising compounds that could successfully treat depression in less than 24 hours with few side effects. The compounds could offer significant advantages over current antidepressant medications. The research, led by Scott...

Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Bhattacharya SK1, Bhattacharya A, Sairam K, Ghosal S. Author information Abstract The roots of Withania somnifera (WS) are used extensively in Ayurveda, the classical Indian system of medicine...

http://www.dailymail.co.uk/health/article-3943298/Breakthrough-DNA-editing-team-discovers-fix-genes-cure-untreatable-diseases-blindness-extend-human-lifespan.html?ito=social-facebook Salk Institute scientists have used new technique to cure rats' blindness It is the first time anyone has...

Three-Step Test System for the Identification of Novel GABAA Receptor Modulating Food Plants Potentiation of γ-amino butyric acid (GABA)-induced GABAA receptor (GABAAR) activation is a common pathway to achieve sedative, sleep-enhancing, anxiolytic, and antidepressant effects. Presently, a...

Determination and Comparison of γ-Aminobutyric Acid (GABA) Content in Pu-erh and Other Types of Chinese Tea "Two previous studies have reported that pu-erh tea contains a high level of γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter in the central nervous system and...

Epilepsy drug Trobalt (retigabine) to be discontinued The epilepsy drug Trobalt, also known as retigabine, is to be discontinued and will no longer be available after June 2017. Trobalt, made by the pharmaceutical company GlaxoSmithKline (GSK) has been available in tablet form at 50mg, 100mg...

The headphones that get you HIGH: $279 Nervana device stimulates nerves in the ear to trigger the release of feel-good hormones Nervana device stimulates the vagus nerve in the left ear through earphone Its makers say this stimulates the release of calming neurotransmitters It works with user's...

Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via theGABA/benzodiazepine receptor complex in mice. BACKGROUND AND PURPOSE: The aim of this study was to evaluate the anti-convulsant effects of magnolol (6, 6', 7, 12-tetramethoxy-2...

"The antispasmodic effect of aryl-substituted α- pyrones from the kava-root have previously been reported, although it was not known that these effects were due to the property of potassium channel activation. It has now been confirmed that kawain is indeed a potassium channel activating...

Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

Effects of alpha-tocopherol on noise-induced hearing loss in guinea pigs. Hou F1, Wang S, Zhai S, Hu Y, Yang W, He L. Author information Abstract Preventing noise-induced hearing loss (NIHL) by antioxidants is based on the hypothesis that generation of reactive oxygen species is one of the...

Dietary vitamin C supplementation reduces noise-induced hearing loss in guinea pigs. McFadden SL1, Woo JM, Michalak N, Ding D. Author information Abstract Vitamin C (ascorbate) is a water-soluble, low molecular weight antioxidant that works in conjunction with glutathione and other cellular...

"Two products of arginine: glutamic acid and agmatine may be involved for anticonvulsant effects of arginine. Administration of arginine and glutamic acid can be effective in reducing the seizure frequency of uncontrolled epilepsy patients, without triggering considerable complications."...

"Even at low doses, D-leucine ( amino acid) suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function...

A wide variety of drugs have been tested as potential tinnitus therapeutics, with generally negative, and a few mixed, results (Dobie 1999). Reports of successful tinnitus treatment using drugs of unknown specificity and unknown mechanisms of action (Jastreboff et al. 1997) may be...

Clinical Trials of D-Methionine: Interview with Kathleen Campbell, PhD September 13, 2013 Interviews Douglas L. Beck, AuD, spoke with Dr. Campbell about phase 3 clinical trials of D-Methionine, an oral pharmacologic, which may be beneficial to help reduce or prevent noise-induced hearing loss...

Phenibut (or, alternatively, fenibut, phenybut) (brand name Noofen, Citrocard), contracted from β-phenyl-γ-aminobutyric acid (β-phenyl-GABA), is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA). The addition of aphenyl ring...

TORONTO, Nov. 19, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC Market: PTGEF, Canadian Securities Exchange: PBT.U), and Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today that preliminary results from a Phase I study with BHV-0223, a glutamate modulating...

Acoustic sound engineer hanged himself after fearing he would lose his job when he developed chronic tinnitus Dr Mark Lawson, 43, of Reading, found hanged at Cardinal Clinic, Windsor He visited specialist unit for treatment for anxiety due to hearing condition Inquest in Reading told he feared...

Read the link below, there's tons more information! There's so many applications...SF really needs to come out, so much potential for so many conditions! The use of retigabine in the preparation of a medicament for: use in functional bowel disorders; neurodegenerative diseases; neuroprotection...

Auditory fatigue – While little data exists, we know of many patients who experience an increase in their tinnitus perception following periods where there are greater demands on their auditory system. The sound does not need to be loud; it can be a situation where there is competing noise...

Protein movement of hair bundles in the inner ear may preserve hearing for life Finding holds promise for repairing damaged hearing Source Each single hair bundle within the live zebrafish ear contains fascin 2b fused with green fluorescent protein. In this time coarse, the fascin 2b molecules...

Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice. Abstract OBJECTIVES: The effect of Aloe vera in epilepsy has not yet been explored. This study was done to explore the effect of aqueous extract of Aloe vera leaf powder on three acute and one...

Tinnitus psychopharmacology: A comprehensive review of its pathomechanisms and management Abstract Background: Subjective tinnitus is a frequent, impairing condition, which may also cause neurotransmitter imbalance at the cochlea. Psychopharmacologic agents, although not being the first-line...

Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. Consroe P, Wolkin A. Abstract A comparison of the anticonvulsant and neurotoxic effects of cannabidiol (CBD), delta 9tetrahydrocannabinol, cannabinol and antiepileptic drugs (phenytoin...

Biological Causes of Depression Biological causes of clinical depression continue to be studied extensively. Great progress has been made in the understanding of brain function, the influence of neurotransmitters and hormones, and other biological processes, as well as how they may relate to the...

Update August 2015 We’re pleased to announce a new partnership project with the University of Leicester. This project will aim to identify a possible tinnitus gene using microRNAs which are recently discovered small biological molecules present in any human or animal cells. Several hundred...

Text from the newspaper article (Danny Boy is not the person mentioned): I have not been able to hear silence for about four years now. The high-pitched whining that you may temporarily hear after you leave a gig is, for me, a permanent fixture. The worst thing about this is that regardless of...

You can also get it in powder form. Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality. Howatson G1, Bell PG, Tallent J, Middleton B, McHugh MP, Ellis J. Author information Abstract BACKGROUND: Tart Montmorency cherries have been reported to contain...

Pu-Erh is tea which contains caffeine plus GABA. Blood-brain barrier transport of caffeine: dose-related restriction of adenine transport. Abstract We studied the transport of 14C-caffeine across the blood-brain barrier (BBB) by measuring brain 14C:3H ratios five seconds after rats received...

Management Team Charles H. Large, PhD (Chief Executive Officer) Charles Large received his first degree and PhD from the University of Bristol and has more than 20 years of experience of drug discovery and development in the pharmaceutical industry. Before founding Autifony, he was Director of...

Here's his policies for young people- If you want to vote for him, register here for 3 pound, to join the Labour party and to enable you to vote in the leadership election. http://www.jeremycorbyn.org.uk/ Young people have been forced to disproportionately bear the brunt of this Government’s...

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201633/ The New Anticonvulsant Retigabine Favors Voltage-dependent Opening of the Kv7.2 (KCNQ2) Channel by Binding to Its Activation Gate Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H Mol Pharmacol 2005;67:1009–1017 [PubMed] Retigabine (RTG)...

http://www.ncbi.nlm.nih.gov/pubmed/11077073 http://www.sciencedirect.com/science/article/pii/S0028390800000976 Involvement of potassium channels in amitriptyline and clomipramine analgesia. Galeotti N1, Ghelardini C, Bartolini A. Author information Abstract The effect of the administration of...

Gynostemma pentaphyllum, also called jiaogulan (Simplified Chinese: 绞股蓝, Traditional Chinese: 絞股藍, Pinyin: jiǎogǔlán), literally "twisting, crotched indigo plant" (or "crossed thighs indigo plant"), is a dioecious, herbaceous climbing vine of the family Cucurbitaceae(cucumber or gourd family)...

I've been using this and it seems to be working. Anyone else use Binaural beats and found relief?

Revolutionary new drug set to be available on NHS cuts risk of fatal epileptic seizures Once-a-day pill, costing £5, helps prevent the most dangerous seizures Trial found 23% of those taking it stopped having such seizures completely Epilepsy affects about 600,000 people in the UK and fits can...

Sulpiride plus hydroxyzine decrease tinnitus perception. Lopez-Gonzalez MA1, Moliner-Peiro F, Alfaro-Garcia J, Esteban-Ortega F. Author information Abstract OBJECTIVES: The aim of the study is to confirm the effectiveness of sulpiride and hydroxyzine in tinnitus patients. The administration of...

Could potentially help treat tinnitus. Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review) Lion's Mane Mushroom...

http://www.jbiomedsci.com/content/18/1/75

As the title says.

Just wondering if anyone has used chlorella for tinnitus and seen any results? Chlorella on Amazon "An effective nerve damage rebuilder A phytochemical found in chlorella can actually rebuild nerve damage in the brain and nervous system. That's why chlorella is being used in the recovery of...

Any thoughts on this?

I need a mega holiday and I will bring some trobalt along with me...

Mine's the Bioshock games and Grand Theft Auto! Oh, and Resident Evil.

Just wondering, does tinnitus make finding love harder? Does it impact your relationship?