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  1. Nick Pyzik

    Hidden Hearing Loss, Tinnitus and Trouble Hearing Conversations in Noise

    Hey Baxter, Hidden hearing loss is really just starting to be recognized. There is a test out to measure the brain's response to noise called an "Auditory Brain Response". I had one done around the winter of last year. It unfortunately showed no issues in my hearing even though I had such...
  2. Nick Pyzik

    Hidden Hearing Loss, Tinnitus and Trouble Hearing Conversations in Noise

    Are you in the field of audiology (hearing scientist)?
  3. Nick Pyzik

    Hidden Hearing Loss, Tinnitus and Trouble Hearing Conversations in Noise

    Thanks again for explaining the auditory nerve in a more sophistaced matter. I've understood that glutamate is involved with the Type-1 Afferents. Glutamate seems to cause subjects' ringing to "spike". I've read about users on here eating food containing MSG and having their ringing become...
  4. Nick Pyzik

    Hidden Hearing Loss, Tinnitus and Trouble Hearing Conversations in Noise

    Thank you for giving me a much more detailed explanation of the nerves involved in our auditory processing system. The Johns Hopkins article gives a very simple explanation and I've been wanting to understand what is really involved. What are the MOC efferent and LOC efferent? If I'm correct...
  5. Nick Pyzik

    How Is Music Produced?

    Music is sound. Frequencies manipulated and put together in a precise manner that each is complimented by one another. I was looking to get some opinions by users and producers themselves on here about how a song is produced. As a musician and once music producer myself, I've become very...
  6. Nick Pyzik

    Hidden Hearing Loss, Tinnitus and Trouble Hearing Conversations in Noise

    Don't you guys think that this discovery plays a part too? Link: http://www.hopkinsmedicine.org/news/media/releases/found_a_likely_new_contributor_to_age_related_hearing_loss That those considered to have "age-related hearing loss", could quite possibly be experiencing the same thing as what...
  7. Nick Pyzik

    Need Help with My Neuron/Cell Theory for Tinnitus

    Could you list out the supplements and antidepressants you were taking? If that's possible? It would be much appreciated. There had to of been damage already before you starting taking antidepressants or supplements. It's strange how the ringing just became audible out of the blue and then...
  8. Nick Pyzik

    Need Help with My Neuron/Cell Theory for Tinnitus

    So you noticed loud ringing for the first time ever only after taking an antidepressant medication? Then things continued to get worse off and on?
  9. Nick Pyzik

    Noise-Induced Hearing Loss Restored in Mice Through Increased NT3 Production

    There's gotta be much more to it than just spontaneously firing neurons. I'm one of the few users on this site I've spoken to that have lost the ability to feel. Truly feel. No connections to people anymore. No connections to my family. I would feel so much happiness from my hearing not...
  10. Nick Pyzik

    Noise-Induced Hearing Loss Restored in Mice Through Increased NT3 Production

    Feeling nothing is pain. I've been told to move on, but there's nothing to move on to. I've felt emotions all my life and now I feel nothing everyday. Plus I've lost all the energy I had before to exercise and what not. I've taken Astaxanthin since I believe late November. There were...
  11. Nick Pyzik

    Need Help with My Neuron/Cell Theory for Tinnitus

    The first thing I always say to myself now when I see someone stating depression, antidepressants, and tinnitus is why did a disorder like such happen in the first place. How old were you when you first started feeling "depressed" and did any other physical symptoms come along with it. Or were...
  12. Nick Pyzik

    Noise-Induced Hearing Loss Restored in Mice Through Increased NT3 Production

    It's hard to tell sarcasm through online text, so I'm hoping that's not how it was intended to be. I was intentionally replying back to Vinnitus' statement "I've seen the topic about the retracting spiral ganglion neurons (SGN) and that a softer Tinnitus might actually mean thatthe SGN is...
  13. Nick Pyzik

    Need Help with My Neuron/Cell Theory for Tinnitus

    It's incredible the immensely miniaturized actions that take place in already such incredibly tiny structures in our body/brain. I wish I had the ability to understand all the terminology and what not. Funny I say that because I may just have to learn all about this stuff since I trying to...
  14. Nick Pyzik

    Noise-Induced Hearing Loss Restored in Mice Through Increased NT3 Production

    It's hard to say yes or no because so much has gone on since last fall (around early October). I could associate taking supplements/herbs that initiate NGF are actually what caused my ringing to become much louder at times, but it's difficult to say so. There were many other factors that could...
  15. Nick Pyzik

    Noise-Induced Hearing Loss Restored in Mice Through Increased NT3 Production

    That's why I feel like a stem cell based approach to repairing/reconnecting/regenerating the nerve fibers or spiral ganglion neurons would do a lot more justice. There's going to be many subjects who have had ringing for almost decades. I'm assuming it'll all be figured out through trials. If...
  16. Nick Pyzik

    Noise-Induced Hearing Loss Restored in Mice Through Increased NT3 Production

    Vinnitus, It's hard for me to recall which month I started taking Astaxanthin, but I think it was sometime last December. I purchased a bottle of 12mg Astaxanthin from a local vitamin shoppe after reading about a user on here talking about it. I can remember how desperate I was to see if...
  17. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I agree. I would really like to know which of the two spiral ganglion neurons perform what and where they connect to back in the brain. I've posted this website on TT an appropriate amount of times. It talks a good bit about the mechanisms involved in our hearing and also about hyperacusis...
  18. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    A question that I wonder too!
  19. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    The nerve fibers extend off of the spiral ganglion neurons. It's hard to say which sort of hair cell they extend off to, but I've read that a single nerve fiber can extend to only one outer hair cell and then multiple other nerve fibers can extend out to multiple inner hair cells. But then...
  20. Nick Pyzik

    Developing a Safe and Efficient Way to Transport Stem Cells Into the Inner Ear

    Aaron, I appreciate the informational response! Would you say you have a pretty reasonable understanding of how the spiral ganglion neurons work within the inner ear? I have a question or two on the spiral ganglion that I was wondering if I could ask you?
  21. Nick Pyzik

    Developing a Safe and Efficient Way to Transport Stem Cells Into the Inner Ear

    Thanks for also posting this segment, Reinier. I still don't understand at all how there are researchers, Rivolta and his team for example, who have found a connection between sensory hair cell loss and hearing loss. But then another team of researchers, like Charles Liberman, have found no...
  22. Nick Pyzik

    Developing a Safe and Efficient Way to Transport Stem Cells Into the Inner Ear

    It seems to just be focused on the auditory nerve. Or in other terms, the nerve fibers/spiral ganglion neurons that are apart of it. Usually there is a mention of inner ear cells or sensory hair cells, but there was none so in this article. Also, Marcelo Rivolta had been previously working on...
  23. Nick Pyzik

    Developing a Safe and Efficient Way to Transport Stem Cells Into the Inner Ear

    Thanks for sharing this beeeep! Any sort of hearing loss news that refers to stem cells and auditory nerve repair makes me feel more hopeful and cheerful inside.
  24. Nick Pyzik

    Pitch and Loudness from Tinnitus in Individuals with Noise-Induced Hearing Loss

    Thanks Kane! Yes. Same here. There are a lot of factors involved so it's hard to give a straight answer. I have my theories on many of it, but there's a lot to type out and I'd rather see what more information comes out. It's pretty scary knowing that the neurons that took part in...
  25. Nick Pyzik

    Pitch and Loudness from Tinnitus in Individuals with Noise-Induced Hearing Loss

    There is too much hype on sensory hair cells because they are the leading front-runners of our hearing. Just because animals can regenerate their damaged sensory hair cells doesn't mean it's the key to a human hearing better. The brain is all processing. The neurons and nerve fibers are what...
  26. Nick Pyzik

    Pitch and Loudness from Tinnitus in Individuals with Noise-Induced Hearing Loss

    YES. 100% agree with the words in bold. I was stating that a few weeks ago to a friend on here. I'm glad there's a study speaking about it now.
  27. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    It's all about your brains processing. The nerve fibers involved are what allow sound to be processed. There are two types of nerve fibers involved that sprout out from what are called spiral ganglion neurons. These two nerves can be termed as "in-going" and "out-going". The more "out-going"...
  28. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    We'll find out somewhat soon if hair cells actually allow one to "hear better". I stand behind the research regarding acoustic trauma to the nerve fibers/spiral ganglion neurons causing hearing loss and also which can even be connected to tinnitus with the latest documents uploaded online...
  29. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    There are many factors to be said for the brain can do to compensate for the damage that's taken place. The deaf can have ringing and the deaf can have no ringing. I link the ringing to damage in the central nervous system. Either a malfunction that took place in the brain at birth or in ones...
  30. Nick Pyzik

    Tinnitus and Emotions

    Not sure if any of you guys have read the article about how people with tinnitus process emotions differently? My belief: The ringing you hear, is what once allowed you to receive emotions from your hearing. Neurotransmitters. The damage has caused your brain to switch it's emotional...
  31. Nick Pyzik

    Tinnitus and Emotions

    Grate, This isn't much of a documented piece of work, but it talks about what you had trouble locating! Link: http://www.shape.com/lifestyle/mind-and-body/your-brain-crying
  32. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Neurotrophic Factors will most likely not be the answer to restoring neuronal damage to ones hearing. Stem cells differentiated into spiral ganglion neurons on the other hand, could hold the key.
  33. Nick Pyzik

    Speech in Noise Comprehension

    What are you expecting at the end of a test performed on yourself?
  34. Nick Pyzik

    Speech in Noise Comprehension

    What do you think is your next move Vinnitus?
  35. Nick Pyzik

    Speech in Noise Comprehension

    Check these out Vinnitus: - Decreased Speech-In-Noise Understanding in Young Adults With Tinnitus http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923253/ - Tinnitus is associated with reduced sound level tolerance in adolescents with normal audiograms and otoacoustic emissions...
  36. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    But remember, there is proof that hearing loss doesn't just mean sensory hair cell death. Or sensory hair cell death at all. In fact, I believe spiral ganglion neuronal/nerve fiber damage trumps sensory hair cell damage. We will see though as new studies come out.
  37. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    They are literally restating the same information that has been posted about hearing risks in young adults in other recent articles. Plus, they're not correct at all about the sensory hair cell damage. Especially with the new studies that have been released regarding tinnitus, hidden hearing...
  38. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    You're right Reinier. I was talking with @Mario martz the other day and he explained to me that a lot of growth has happened lately. There are plenty of corporations/foundations out there researching their butts off. Time is the question. My friend @Sasja linked me to this last night...
  39. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    There's a lot to still be understood about what can be titled as Hidden Hearing Loss / Tinnitus. The damage that occurs is much more hidden than we think. @Aaron123 was able to spot and correct my false information about how long these neurons/cells can survive without connection the inner...
  40. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Have you seen these Aaron? Both recently posted in the same month by different researchers: Tinnitus is associated with reduced sound level tolerance in adolescents with normal audiograms and otoacoustic emissions http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893619/ Decreased...
  41. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I apologize for not including a s to "year" Aaron. But yes, I should of included his actual statement from "The Hearing Review" posted on May 13th, 2014. “Each missing synapse represents a cochlear nerve fiber that has been disconnected due to retraction of the terminal segment—it will never...
  42. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    BDNF is a protein that allows neurons in the brain to survive. Loud noise first causes disconnection of nerve fibers from the sensory hair cells, then the fibers retract back to the spiral ganglion neurons they were associated with (I or II), and from their the neurons aren't receiving any sort...
  43. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    What caused your hearing troubles?
  44. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I'll answer your questions in a very simple manner. I was typing out a huge response, but there's really no point. Neurons are electrically excitable. As I'm sure you know, they're involved all throughout the brain. Billions of them. As long as you have a synapse in relation to a neuron...
  45. Nick Pyzik

    This Is Your Brain on LSD, Literally

    We shouldn't even be having to take anything at all. Our brains have evolutionized enough along with our genes to allow us to survive and feel good naturally. Unless you felt out of the ordinary and depressed as a child, then you shouldn't be having to take any sort of drug, medication, herb...
  46. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Kane, Unfortunately the combination of information provided by recent research on tinnitus/hidden hearing loss and the not so distant research provided by Charles Liberman makes me have to say yes. The best thing to keep your brain healthy and keep these brain cells/neurons alive is to keep...
  47. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I'm only going off of the information I've gathered up as a whole. @Mentos was able to actually contact Charles Liberman himself. He even stated himself in one of a few articles talking about noise, hidden hearing loss, and nerve fiber damage. Here is an excerpt from The Hearing Review...
  48. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I'm not too sure about neuronal/cellular death and how much time influences it. I do know that with acoustic trauma, excitoxicity is involved. Especially with one of the the spiral ganglion neurons. Once I starting reading up on them, I have a much better understanding of their background...
  49. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I'm stating that acoustic trauma to ones hearing is most likely not hair cell damage like these foundations/researchers are displaying. It just doesn't make sense that certain researchers would find that a measurably loud db level would cause zero hair cell loss in an animal subject, but yet a...
  50. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Thanks grate_biff :)
  51. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I have looked through that. I actually have been taking supplements for numerous months that have Nuerotrophic factors or cellular protective properties. Ashwagandha, Lion's Mane, Cordyceps, Astaxanthin,(found Astaxanthin thanks to another user way back in November of last year). It's great...
  52. Nick Pyzik

    New Stem Cell Transplantation Method Restores Damaged Auditory Pathways

    Decreased Speech-In-Noise Understanding in Young Adults with Tinnitus http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923253/ Uploaded online on June 28th, 2016.
  53. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I spoke to Jeff the other day and he told me he had audible ringing while he was younger. He never noticed it as much later on in his life and hasn't with the Cochlear Implants he has now. Genetic hearing loss could also mean issues between the brain and the inner ear. If the GenVec did not...
  54. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I'm still trying to learn what I can about how our brains interpret sound so I can't give a very detailed response back to what you've asked Bill. From what I've read, it seems as though the ringing one hears is due to the loss of spiral ganglion neurons, which I believe were apart of the...
  55. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Greg, I don't recall Jeff talking about having ringing at all. Here is part of my conversation with him regarding how he developed his hearing loss. (12/09/15) 6:26PM Me: Jeff, how is it going? I was interested in how your Novartis hearing treatment went and if you have had any improvement...
  56. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    But how do we know if that increased hearing loss is not just due to an increased amount of out-going nerve fibers connected to the still-remaining sensory hair cells? I understand that researchers have been able to create new established connections between the new sensory hair cells and the...
  57. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    RB, I remember I did try to find Amanda on Facebook back while I was on the hunt in December. I wasn't able to find her after several attempts. Jeff Bricker did mention "in the case of a few other lab rats", so he must have spoken to other members of the trial. I was speaking to Jeff...
  58. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I'd like to ask why researchers state that it's the sensory hair cell death inside a human's cochlea(s) that cause hearing loss? Why has there been research, most specifically by those of the Harvard Medical School, displaying absolutely zero sensory hair cell loss while a visible large...
  59. Nick Pyzik

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I'm telling you. They aren't looking at hearing loss correctly. It's the nerve fibers of the spiral ganglion neurons that cause hearing problems, ringing, and much much more. I'm not denoting sensory hair cells though. I'm sure those who may have lost hair cells through ototoxicity may...
  60. Nick Pyzik

    Are People Who Get Tinnitus Generally Unhappy About Their Life?

    I'm with you there Bill. Except for the "looking forward to death part". You have to be smart enough to not even think about wanting to end your life, no matter how difficult things become. A reward is always at the end of a strenuous journey. Life is a gift.