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  1. J

    AM-101 Clinical Trial — Participants Updates and Discussion

    Just an update ~2 mo. post open label (1st round): staff says I've shown an improvement in my hearing sensitivity. I'd wager this is due to the fact that my T is quieter, so picking up on quieter sounds is done more easily. Previously, I couldn't hear the sounds past a certain threshold, as my T...
  2. J

    Pitt Team Identifies Cause of Resilience to Tinnitus, Potential Drug Theraphy

    This makes sense to me. Treatments for tinnitus will probably be a combination of things, whether it be medication, rTMS, therapy, or some combination of these things. I won't venture to say "this is it" but there may be some promise here. The findings here could also provide a possible...
  3. J

    Questions Regarding AM-101 and TRT

    I read somewhere that the nerve "healing"/reconnection to IHC takes about 5 days in mice. Perhaps that's why the injections for AM 101 occur over 5 days. As long as the glutamate storm is quelled for this healing time, there can be recovery (is what Auris Medical is presuming, I believe).
  4. J

    AM-101 Clinical Trial — Participants Updates and Discussion

    I'm inclined to agree with you, here. From the reading I've done, the best treatment for T will be multimodal. Thus, treating or repairing the inner ear followed by some sort of therapy for the brain to readjust would provide the best results, in my opinion. This is opposed to treating just one...
  5. J

    AM-101 Clinical Trial — Participants Updates and Discussion

    Just an update: My last injection was last Friday and I was back to baseline (perhaps a tad bit lower, it's hard to tell) a day or two ago. My ears don't feel all that full or clogged, either. My eardrum also healed within a day of each injection but that may just speak to the method that the...
  6. J

    AM-101 Clinical Trial — Participants Updates and Discussion

    Question: has anyone that is fairly certain they received the placebo return to baseline pretty quickly after the injection? I guess I won't truly know until a month or two from now but I'm curious in the meantime.
  7. J

    AM-101 Clinical Trial — Participants Updates and Discussion

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333796/ That's one I found particularly interesting. There are more papers on neuroplasticity and tinnitus but I don't have them on hand. Edit...
  8. J

    AM-101 Clinical Trial — Participants Updates and Discussion

    Doing okay so far. In the middle of the injection, my T increased but, today, it doesn't seem as loud as it was directly after the injection. I have some muffled hearing, but, as I understand, that is normal. I have my final injection tomorrow, then about a 3 month waiting period before the...
  9. J

    AM-101 Clinical Trial — Participants Updates and Discussion

    I've been lurking this forum without an account for a while, keeping up with clinical trials and such. I created my account to say that I'm in the AM 101 trial and I'd describe my tinnitus as 3/10-ish. I figure I'd rather try this than live life wondering. If it works, I could potentially drop...