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Introduction: During the last decade, a number of candidate drugs for the treatment of tinnitus have emerged with the hope of alleviating the burden of millions of sufferers with a persisting ringing in their ears. Knowledge of the pathophysiologic mechanisms has progressed remarkably in the...

Otonomy posted their 1st quarter financial results today. I think most of the stuff in there is already known, however, it gives a nice short summary about their drug pipeline...

The results have been published: https://www.ncbi.nlm.nih.gov/pubmed/29712507 The full article is freely available, too! ;) http://journals.sagepub.com/doi/full/10.1177/0194599818767618 Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial.

Only slightly interesting despite the title: Apawu AK, Curley SM, Dixon AR, Hali M, Sinan M, Braun RD, Castracane J, Cacace AT, Bergkvist M, Holt AG. MRI Compatible MS2 Nanoparticles Designed to Cross the Blood-Brain-Barrier: Providing a Path towards Tinnitus Treatment. Abstract: Basically...

Quite interesting. If it would be possible to take a high-resolution look at the cochlea of people with T/HL, this would probably be a game changer. Finally, we could know what is *really* going on, instead of just guessing. However, seems like this method is not (yet?) up to the task: So...

Not really big news, as Auris already announced they would continue the phase 3 trial with an "amended protocol". Seems like that restart just happened. Auris Medical Resumes Enrollment in TACTT3 Phase 3 Trial of Keyzilen in Acute and Post-Acute Tinnitus

But don't you know that Big Pharma is not in control because all their T advances are destroyed by the mighty hearing aid industry? I read it on the internet, so it must be true! ;)

Didn't see that coming... This might be of interest for people taking part in the AM-101 (or similar) trial or having intratympanic steroid injections: Using anaesthetics doesn't help reduce the pain of the injection

https://www.boehringer-ingelheim.com/press-release/china-southeast-university-collaboration-develop-hearing-loss-treatments They started working with Kyoto University on this topic earlier this year...

I guess the study finished, at least there's a matching publication: https://www.ncbi.nlm.nih.gov/pubmed/27716604

Well, sometimes you stumble upon strange things. This is definitely one of 'em... ;) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803736/ Basically they are currently trying to help people with cervical pain syndrome using cervical collars. A larger paper is in preparation. The article reports...

Just wanted to post this, too, but obviously it's old news. ;) Anyway, wanted to give this a boost as not all humble bundle customers might have seen this yet. Btw, you can choose to donate to "Action on Hearing Loss," too.

Action on Hearing loss funds research on stem cell delivery.

See their NEWS page entry from September 1st (unfortunately there's no direct link to the article, only to the news page). PRAGMA Therapeutics and UK Ministry of Defence’s Center for Defence Enterprise collaborate to support preclinical research on innovative treatment for tinnitus September...

Hmm, just stumbled over a previous study where they injected Gacyclidine (OTO-311) into the ear: Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series. It's somewhat older (05/2010) and only a small number of people participated.

See the post of @James White above. Otonomy has taken over the research, and this is probably OTO-311. Otonomy Press Release

Wow, didn't expect this: I haven't read the full study yet, but if anyone's interested, it's available online.

Hmm, you can find strange things on the internet: Boehringer-Ingelheim offers a $15k bounty for the Identification of Druggable Targets to Reverse Hearing Loss Unfortunately the Challenge is already over, so no $15k to earn here anymore...

Well, seems like AUT00063 is useless for age-related hearing loss, too. They just posted results for the CLARITY-1 study, and it didn't do anything... Autifony Announcement However,

https://www.statnews.com/2016/07/13/hearing-loss-decibel-steven-holtzman

From the press release: "Top-line results from the TACTT2 and TACTT3 trials are expected in August 2016 and in the fourth quarter of 2016, respectively." Until then, it's only speculation. As @swc5150 wrote above, there are plenty of posts in the other AM-101 threads where people speculate...

Seems like it's almost there... Press Release

More interesting basic research on how hair cell regeneration works. Action on hearing loss has a nice article summarising the result. Or take a look at the journal article. Short summary: Birds do it, fishes also (where "it" means regenerate hair cells, of course...). So they looked at what...

Seems like they're trying to find other uses for the drug. Reading this it seems like the CLARITY-1 trial is doing better than their QUIT-1 trial (of course this is just speculation)... Autifony Press release

Sorry to Dis-dissapoint you ;), but "[...]the Data Safety Monitoring Board (DSMB) for the Phase 1/2 clinical trial of CGF166 in patients with severe to profound hearing loss has recommended that the trial continue, [...]"...

Somewhat off-topic, but I just stumbled over an interesting article in Scientific American about chronic pain. While it's not about tinnitus, it might still be an interesting read for those interested in the broader context, as the mechanisms in play are somewhat similar. The basic mechanisms...

Saw this, too. However, seeing that they still list Merz/Neramexane I wouldn't count on this report being up to date. I don't think it contains anything you can't find on Tinnitus Talk...

I wouldn't get my hopes too high. Seeing that there was really no difference between placebo and AUT00063 and considering that they had ~80 people, I don't think there's any subgroup hidden in there that had benefits. Would make a much larger dent in the data. Well, OK, there's one subgroup for...

Not sure why no one found this yet, but Autifony posted a summary of the QUIET-1 study: http://www.autifonytherapeutics.com/publications/Autifony_QUIET_Final_data_FINAL_28April2016.pdf Summary: There was basically no difference between the placebo and AUT00063 group. Highlights: - AUT00063...

Actually, dead hear cells don't leave any free seats either for the stem cells. They are replaced by supporting cells to protect the underlying neuronal endings. (Basically, hair cells are surrounded by endolymph on one side and connect to the neuronal endings on the other side. The endolymph...

Obviously, that yellow guy habituated pretty well, just look at him. So why should he risk his health swallowing some untested drug? ;)

Sorry to say, but that's NOT what they are saying. hey did preliminary experiments on Chinese ovary hamster cell cultures which evaluated one aspect of the drug. They never said "It will work in humans and is harmless". They designed it to be more harmless, based on some assumptions about why...

Ohh, just found this on the net: There's a study being conducted in Pittsburgh where they try this "balloon dilation" procedure for ETD. Seems like they're still recruiting and it's not too far from NY. Just don't get depressed if you are in Pittsburgh while the Penguins eliminate the Rangers...

I guess you already saw an ENT about the issue? What kind of ETD do you have? Clogged tubes? In that case, regular (and careful) nasal irrigation might help. There's one study about diving-related medical disorders (divers seem to suffer ETD and inflamation of the tubes quite often), which...

Sorry, just saw that Glynis already gave basically the same answer.

Hi Sarah, don't panic. There's indeed something moving in your skull, it's your jawbones. Hearing it from time to time is normal. You could ask your dentist to check if you have temporomandibular joint disorder. However, as long as there's no pain there's probably no reason to do anything.

I didn't mean when screening molecules, but before entering phase I in humans. You have to do some tests, and as far as I know for toxicity tests you must use at least two different species. Wikipdedia says: "Importantly, the regulatory guidelines of FDA, EMA and other similar international and...

They did that, but studies showed that this stuff is just as fake as most other therapies. There are studies showing benefit of those therapies, but they mostly use rather dubious methods for analysis, basically measuring the placebo effect (which can be huge for T). Nowadays, the only thing...

There are tons of tests to be done before a drug can even enter human trials. Concerning the vast amount of potential drugs tested each year, I doubt there are even enough chimps around. Just take a look at page four of this publication by the Association of the British Pharmaceutical Industry...

B.t.w., just a quote from an article in the Time magazine with a leading Alzheimer researcher: "My biggest frustration is that we’ve cured Alzheimer’s in mice many times. Why can’t we move that success to people?” Longo says. (He’s referring to numerous promising compounds that have eliminated...

If you don't care about it, it's no problem if you can't mask it. For example, after my T got bad, it was real hard for me to concentrate and be productive at work, 'cause the T just occupied me completely. Nowadays, I can concentrate like I did before. The T is surely there, but I just don't...

Apart from the issues listed there, a vestibular schwannoma normally causes high-frequency hearing loss and T, often only in one ear (although you might get one on both sides). As far as I know, most people have a T with ~4kHz.

It's there, it's as loud as ever, with as many different frequencies. But I don't notice it for a long time, and when I notice it, I don't care no longer. I never though I'd get there, because I can basically hear it everywhere. Under the shower, in the cinema, in a restaurant with many people...

There's a good reason new drugs take so long until they even start Phase I studies. http://www.sciencemag.org/news/2016/01/what-we-know-so-far-about-clinical-trial-disaster-france A person died and several got serious brain damage during a phase I trial for a drug that "aimed at multiple...

Uhh, where did you find this information?

Well, there are many many people taking this kind of drugs, compared to the number of people that get stem cell treatment or gene therapy. So the interesting question is how high is the percentage of people that die of the drugs? There's always the chance that stem cell treatment goes horribly...

Me. I have HL and T in my left ear. I don't know how bad your HL is, but mine is worst at around 2kHz, where I lost ~50kHz according to my last audiogram (and it gets worse each time a new audiogram is done). When it started back last summer it was really bad, and I also suffered when it got...

Same here, happy and content, and I'm just fighting to get there again. And slowly, it's working.

Hi glynis, just out of curiosity, what dose of prednisolone do you take? Did the T go away on the first day already? And what's the stuff you're inhaling (what's nebs, b.t.w?). Hope it stays that low for you after tapering off!

Btw, for those with Meniere's: The European part of the OTO-104 Phase III trial just started. http://investors.otonomy.com/phoenix.zhtml?c=234082&p=irol-newsArticle_Print&ID=2150394

Some googleing brought up a book by Dr. Eberhard Biesinger "Tinnitus - Endlich Ruhe Im Ohr" (rough translation: Tinnitus - Silence in your ear at last). It's a book about Tinnitus that (according to the amazon summary) "[...]gives you an overview of all useful treatments[..] including TRT...

"Profiles of NMDA-R antagonists in clinical development for the treatment of tinnitus" According to the booklet it was presented in the "Preclinical interventions" session on Friday, 11:45h-12:00h. But as I said, it's just a pharmacological comparison of both products to show that OTO-311 might...

I don't think there's any condition where cuddling won't help. My girlfriend has been a real great support. And my cat, too. I think there's even some study showing that pet owners are happier than other people. ;)

Hi @Steve , Thanks for the report! I browsed the booklet and saw that one of the posters (P111) is from Autifony concerning their AUT00063 trial. Did you by chance see the poster and manage to get any information about the trial? Btw.: I also saw that there was a paper by Otonomy (O048...

Interestingly, there is a trial for Ambroxol as a cure for Parkinson... https://www.cureparkinsons.org.uk/news/promising-respiratory-drug-focus-of-new-trial-for-pd

The patent states that it can be compared to Lidocaine, which seems to be useful (there's a discussion in the treatments section about it) but can cause quite severe side effects, whereas Ambroxol seems to be quite harmless. The proposed mechanism of action is, according to the patent: ————...

Has someone here noticed any difference to their tinnitus when taking Ambroxol? It's the active ingredient of several cough medicines and seems to have pretty few side effects and is pretty cheap. Actually, it's available without prescription in Germany (and probably everywhere else). There...

One more thing. I just got hold of the paper. It seems to be pretty basic research. They did some computational biology (i.e., simulations) to check why central nervous system (CNS) axons don't regrow while those in the peripheral nervous system (PNS) do over time. Seems like they don't send the...

Time to try another drug? ;) Interesting side node: While googling this stuff, I came across the following post on a German forum: https://www.tinnitus.de/showthread.php?4610-Mucosolvan-Hustensaft A rough(!) translation of the first post: In a later post he vaguely wrote about the dosage...