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I love the optimism but I'd bet a lot of money patients are gonna pay for this.

Humans always want more than what they have. This is not a bad thing either - it's how progress happens. If tinnitus becomes treatable with Dr. Shore's treatment, then we're all better off, but there is more work to do with auditory issues in general. Tinnitus isn't the only thing most of us...

I don't have a link handy but she's mentioned she does have tinnitus before in an email response to an email sent by another person here.

Most of us here have had tinnitus for a while. You should be more grateful - all of us old timers have dealt with not just tinnitus but numerous letdowns and scams through the years. It's actually insane how many people want a solution for this but one doesn't exist yet. Finally, we have a...

When my tinnitus is loud, I'm able to regulate it with all my face and neck muscles. I wonder if this device works for not just somatic tinnitus like what I have, but other types too, assuming the others are persisted in the DCN.

Considering we're all used to studies that lack crucial elements like placebo and control groups, seeing that this study was so robustly done and produced such large volumes of data that all point to it being very effective is something none of us expected. It was inevitable that effective...

Some scientists abide by the principal of giving their research to society to improve it. Susan may or may not be that but until the final result of her research (whatever this device is) comes out, we shouldn't judge yet. You're right that all professors work to get grant money but it doesn't...

This is how I feel. When I listen to Susan talk about her research and auditory pathways, it's obvious she's a brilliant scientist who knows what she's doing. She gives off classic genius scientist vibes when she talks about her work. But that doesn't mean that this is going to be a slam dunk...

Then perhaps tinnitus is more related to how well the synapses are functioning, not the hair cells. Improving the hair cells may help hearing, but if your synapses are having issues, then they would need to be treated to alleviate tinnitus. Just a guess of course, I know the brain can adapt and...

Always good to hear another company getting into this space. The more the merrier. They will all push each other in the race for a cure. The more that get involved and the more promising the treatments all start looking will only incentivize them all to work harder to get their solutions to market.

As treatment protocols start being formulated for tinnitus, they will likely approach it from as many angles at the same time as possible. I can imagine down the road a drug may exist for hearing loss using several of these compounds that are being tested + perhaps some form of modulation...

Biotech PhDs are getting into en-masse this because its a major problem and beneficial to all of humanity. Tinnitus and hearing loss are horrible, and on the one hand it's sad it's common, on the other hand that's motivating a lot of researchers to figure out a solution for it.

Dr. Linnman got back to me. I'll post updates here after I participate in the study.

I emailed Dr. Linnman and asked if I could receive the treatment. I live close to the research facility. Hopefully he gets back, with a yes. This looks very safe and the protocol makes sense to me. Seems low risk high reward to me. If this alleviated my tinnitus to any degree I'd be very happy.

You could ask that question anytime a legitimate treatment is created for any condition or disease. Researchers have been circling around a bunch of possible ideas for a while, some of them are bound to work once the right protocols are figured out.

This news is awesome but I need to know their timeline to getting this to human trials.

I suspect these higher dose trials are going to have very good results for both Otonomy and Frequency Therapeutics based on how their original formulations performed. Now that we know they're generally safe, it's time to maximize their effect!

I live 20 minutes from Boston but personally I would not want to participate in this study. 3 hours of noise where you rate how discomforting the sound levels are sounds bad to me.

That's a little creepy that all those own it. I mean, good for Frequency Therapeutics, those are the biggest dogs around. But I'm extremely concerned of Blackrock / JP Morgan owning anything that matters...

I wouldn't be surprised if after years of tinnitus that both sources (cochlea and brain) are involved. Which means you can treat both individually. Just speculating here, but I wonder if a combination of OTO-313 and Dr. Susan Shore's device could bring an 8-9/10 chronic tinnitus down to a...

Alright, who's doing this? I'm interested in doing this in the next couple years but can't now because of work demands.

Thank you for asking. Right now its very noticeable. Fortunately I've had decent days in the past month. The noxacusis that came back was really stressing me out at first but is getting progressively better. I took an online hearing test and my hearing was great so that's not the issue, as...

The whales are accumulating.

Sad news for me. I'm very careful with my hearing these days but I had a spike recently after hanging out with my cousins. It feels like I've developed mild hyperacusis and my ability to discern voices seems worse now. I usually wear earplugs around them especially if all of them are over, I...

That's infuriating. They blow your hearing out more and then sell you hearing aids. So awful to hear.

So much better than Audiograms. Finally we're getting real tests and real solutions. If we don't have robust testing, even if we have solutions it will be difficult to figure out which solution to use. Great news.

We use extremely old (and I'd say, outdated) ways of evaluating a person's audiological improvement using these drugs. If they can show the cochlea is regenerating, I don't care what the old tests say, that is progress forward. This is a hard problem that many researchers and drug developers...

Yeah I was going say, people just say anime because it's less words / typing than Japanese animation / cartoons lol. Like how people say manwha even though it just means Korean comic book / graphic novel. I'm too lazy to write all that shit. Most of us are :p

Years later and I stumble upon this epic potential copyasta. Ranting about Japanese words or culture being used "incorrectly" by non Japanese is one of most epic things you can do on the internet. Thank you for your contribution.

The pessimist in me thinks this is because @generalfuzz was able to create an application from the research and release it for free, which could spook pharmacy corporations from investing money into further research and improvement of the technique. I would hate to be right but it feels possible.

My understanding is the order of operations won't matter much here. Susan's device is targeting neurons misfiring in the brain which can happen whether your tinnitus is caused by acoustic trauma or something else. For people with acoustic trauma, taking a regenerative therapy and also doing...

Great points that everyone needs to understand. They're testing a drug to restore hearing. They don't want to have anyone with any conditions that could affect their maximum perception of improvement. It's why they exclude Meneire's and others. They want to show as large gains in hearing...

@Contrast ytmnd is back https://weareonline.ytmnd.com/

I understand you're trying to not get worked up over it, but stop comparing it to the flu. Compare it to SARS and MERS, which it's more closely related to with regards to its genetics, symptoms, and mortality rate. The WHO thinks it's 17x more deadly than the flu. So it's not the flu. The flu is...

Right, and its so contagious during asymptomatic periods that if it becomes more virulent, that won't downgrade its spread. Which is really concerning since all viruses mutate. We might have dozens of variants of these in a couple months. Especially because every time it infects someone, the...

Yeah I love it when people say "It only kills the sick and elderly, stop panicking". Most of us know people who are sick and elderly. How about you say that to their face and see how you feel, if anything? I assume most people saying this as a way of minimizing the emotional reaction are...

Honestly one of the greatest posts I've ever seen in my life.

lit taste

I have yet to master the left hand path

You must have 1000 IQ to enjoy this song

Would headbang to

The Promised Neverland - watch it

the best part about the bible is the story where god condemns a city of homosexuals and a guy who finds out it's coming flees with his family while god is firebombing the city and while they're running his wife looks back and gets transformed into a pillar of table salt

if you're not gay, please go away

ok time to make an anti-mobile chan that blocks anyone who tries to access from a device that sends a user agent of iphone or android

holy shit that's a great idea

mfw a normie posts a facebook-tier meme with a minion on it

im done with normies

I am, it's honestly an excellent FPS, combining the best aspects of PUBG/Overwatch/Fortnite/CoD into one game. My only issue is your walk speed is so fast that I find ADS aiming super difficult.

wut Your statement about high quality is nonsensical. CDs are physical hardware that become damaged and can have data become inaccessible over time on them. Lossless files are forever the same 1s and 0s. Host and release the lossless file, its 2018 people have 150 MB/s download speeds now and if...

They're not mutually exclusive. We should do both ofc.

woke

You're more woke about free software than 99% of people and you aren't even into software development. It's hugely important and not enough people are aware it even is something that matters.

tinnitus.jpg

I'm ready to do that and post video of it when you are <3

this will push you over the edge to rewatch it

this man is the official thread mascot of page 266