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  1. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Desensitization. I hated needles but after a week couldn't care less. Ended up with a bucket of needles after the course was complete. Don't look, stab, and inject. Simple
  2. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    SSHL is from burst artery going to the ear, not noise damage. I had tinnitus before but it was low, when I got SSHL I had massive noise bleeds, then pretty bad tinnitus. Was due to high BP, not any physical trauma. As for tinnitus being linked, I cannot positively say. I have SSHL in one ear...
  3. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Did you read the paper? This is for treatment of SSHL, not tinnitus. Recovery rate was low and within the 60% of use of Prednisone close to the time of injury. Even so the good audiograms had little improvement and nothing you would call a recovery. Tinnitus had little to no improvement...
  4. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    I'd probably say little to no effect to be honest. All the salvage treatments had a narrow window of recovery from trauma, Prednisone is the primary (controversial) treatment for SSHL. 2 years after the fact, I doubt it. But if you have the cash why not, I'd recommend IGF1-LR3, it's cheaper but...
  5. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    I read in thread that the clinic was charging $6000 for the treatment. I DIY'd the treatment for a fraction of that, same results...
  6. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Someone sent me a link that you've been commentating on: https://www.tinnitustalk.com/threads/south-korean-clinic-treatment-dr-minbo-shim.19340/ http://cmclinics.com/ So no I didn't make that up. Papers I posted used intratympanic injections, 3-6 in total I believe. The course cost me $600...
  7. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Lol I never said I wasn't a douche too. I can tell you now they have really bad tinnitus. It's to do with very high blood pressure rupturing the vessel I'm talking about. I did a high dose but they did much higher than I did. And they have worse tinnitus. In relation to above, IGF1 will heal...
  8. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    I would not risk an intratympanic injection, too many horror stories. I'd rather flood my body with IGF1 than do that, it's insane risk. Lots of witch doctors offer this, they charge $6,000 for $15 worth of IGF1 and you take the risk. I know people are desperate for a cure but please don't risk...
  9. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    ^ Anti-aging clinics and YouTube. Logging back in after 2 years. I've done 3 courses of IGF1 since, both acute high dose and long chronic dosage and little to no effect on hearing. If it did work then body builders would have amazing hearing, in reality it's the opposite. The cure is...
  10. XDR

    South Korean Clinic Treatment (Dr. Minbo Shim)

    Logging back in after 2 years. As I expect nothing has changed. Have a thread on IGF-1 for SSHL, in short since I've done 3 courses of IGF1 since, both acute high dose and long chronic dosage and little to no effect on hearing. If it did work then bodybuilders would have amazing hearing, in...
  11. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Final update After a whole series of tests and months on IGF1, I can say that the treatment did not work. After a few traumatic life events, my hearing and T is now worse. Speaking to a neurologist, he agreed that the cause (and cure) is a vascular issue/treatment. IGF1 was a good precautions...
  12. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Prossibly, will have to look into it. Ventilin doesnt help T directly but makes me sleep better, sometime I will wake with sleep aponia(and associted BP spike), with Ventilin I wont. Might give Oxytocin a go. I measure my BP and it was a insane 170/120!, This morning 150/100. I had 3 bags of...
  13. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Week7 After lifting some heavy wheels and tyres, T and hearing loss came back with a vengeance. Still high even after a few days, havnt been drinking much water either, hence higher BP. Which is fine, supports my theory that T is not hair damage but blood hammer / vessel damage. Not yet, as...
  14. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    What I did notice leading up to my SSHL is that I got bad nose bleeds. I never had nose bleeds in my life. So it seems it can be related as a vascular failure/damage of some sorts that lead up to SSHL and T. That will be my next test, I'm getting a BP meter off my relative this week. I notice...
  15. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Week6 No difference Thanks for this, starting to see a pattern here. People have reported T going away at high altitudes and Barometric chambers (therapy) then when back to normal pressure it will come back. Now I need to come up with some idea how to measure vascular pressure in the ear and...
  16. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Week5 No change, tinnitus increased after I lifted some heavy stuff then died down. Then T increased when I was not drinking any water, drank water then it died down. If T is loud at night I lay on opposite side of the affected ear and it dies down quickly. Also on the morning sometimes T will...
  17. XDR

    SSHL & TINNITUS

    Sorry to hear this Mike, I have SSHL but nowhere near as bad as yours. I'm wondering if you have "ear fullness" feeling in the affected ear by any chance?
  18. XDR

    I Would Like a Few People to Do a 1-Week Experiment with Me and Share the Results with the Forum

    Better experiment would be simply to measure blood pressure how it affects Tinnitus. I strongly suspect that T is caused by damage the circulatory system into the ear. Change in blood pressure will change the level of T. Once that's confirmed, then devise an experiment to measure blood flow in...
  19. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    to supply go to an anti-aging clinic or anti-aging doctor. Then take that prescription to a compounding pharmacy, all legal and getting the real deal. Heard some horror stories with black market crap. I get it for $400 for 1mg in 5mL. Its 10X more potent that HGH, so 0.2mL injections a day will...
  20. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Week4 Pace of gains has slowed, looks like I'm in the long haul. Went to a shopping center yesterday and I had trouble making out speech, depending on background noise. On the other side however, it doesn't bother me as much. Despite the treatment not being as effective as I hoped, what has...
  21. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Its ok but still way off. I went to a crowded shopping mall and felt like I made little progress. Still way off calling it a treatment. When its not that noisy speech seems better, I was not really able to understand my wife with my damaged hear when I first got SSHL. Now I can understand but...
  22. XDR

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    My thoughts on T with my DIY hearing loss treatment, https://www.tinnitustalk.com/threads/igf1-insulin-like-growth-factor-1-as-sshl-salvage-treatment.16310/ tl;rd - although hearing is being restored, Tinnitus (and magnitude of) remains the same. Suspect vascular issue.
  23. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Day 13 Took 2 days off from treatment (5days on 2 days off), this is first weekend off, wanted to gain ground quickly to start with. There is a point where the body becomes tolerate to large doses of IGF1, so trying to keep the window of efficacy open as long as possible, from what I read...
  24. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Not sure about traditional steroids, I know cortico steroids are good as vascular dilators. They use prednisolone for Sudden Sensorineural Hearing Loss (SSHL) as first line (and only) treatment within a two-week window. I was on a high dose (50mg per day) after 2-3months of injury, no effect on...
  25. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    ^I think so too, yesterday highlighted that for me. Day6-8 of Sudden Sensorineural Hearing Loss (SSHL) treatment During day 6 as the drugs thin out of my system (IFG1-lr3 has a 24hr half life), I took a long walk that day to test ear fullness effect which was ok, however Tinnitus (both ears)...
  26. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    No problem, happy to help this community. But to be clear this treatment is for sudden hearing loss and recent suffers, not chronic suffers and not Tinnitus, though both are interrelated. In my case I suspect a vascular issue, hence the HGH on the side. another side note, sometimes I would...
  27. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    OK this a dead thread so will turn it for a diary for myself. Got prescriptions and drugs delivered, talking with the doctor that specialises in sports injuries and treatment with peptide, recommend CJC 1295 as well. This is a synthetic HGH /IGF1 growth hormone, suppose to really boost IGF1...
  28. XDR

    Kyoto University and Boehringer Ingelheim Team Up to Fight Hearing Loss

    Main thing about chemistry or any science, what is important is the scientific method when dealing with a research problem. Coming from Chemistry side, I don't think traditional small molecule will solve T. Its either regenerate the nerve or block the faulty signal by capping the dead cells with...
  29. XDR

    MDMA (a Component of Ecstacy) Potential for the Treatment of Tinnitus

    Pointless study, mechanism for T is known, E is not a treatment. NMDA receptor antagonist, much like AM101 and Ketamine. Its temporary blocks the sites on the cochlea hair, opposed to aspirin (salicylic acid) that attacks it...
  30. XDR

    Kyoto University and Boehringer Ingelheim Team Up to Fight Hearing Loss

    Chemistry, to me this is work. There will always be gaps in literature, lack of knowledge with T is staggering. . In my readings T is still rather unknown. I will write a hypothesis about blood hammer too in the ear. After found to 3 ENTs, their education stops when they graduate. So suffers...
  31. XDR

    Kyoto University and Boehringer Ingelheim Team Up to Fight Hearing Loss

    I'm not a medial doctor, so outside guidance is required, I know these are powerful drugs. I am a scientist by trade, so I'm trying to be as methodical and logical as possible. Also I plan to document this treatment and submit my result to Kyoto university for them to ponder over in a group...
  32. XDR

    Kyoto University and Boehringer Ingelheim Team Up to Fight Hearing Loss

    I'm not my brother is, a decade ago he had a huge tear in his shoulder. Doctors told him will take months to remove the cast and can never lift again. 3 weeks later, he was able to remove the cast. 2 months later was back in the gym. I'm obtaining these legally thought a sports clinic, I should...
  33. XDR

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Unproven snake oil. Wait until Novartis competes its study into the technique next year. https://www.actiononhearingloss.org.uk/community/blogs/our-guest-blog/the-first-gene-therapy-trial-for-hearing-loss.aspx...
  34. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Its does in the paper, in my case, I will know soon. Its a long shot but worth a try with my recent damage. Delivery method is problematic when it comes to the inner ear. Thought about topical but given the structure of the ear drum and cochlea, I very much doubt it will work. Topical when...
  35. XDR

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    I think damage to all; nerves, veins and arteries. Cochlea is basically an air balloon that converts air pressure to sound. Overload it, the balloon and supporting systems are damaged, get a stuff signal. Much like a oil pressure sensor on a car. This is all my theory though and making a...
  36. XDR

    Kyoto University and Boehringer Ingelheim Team Up to Fight Hearing Loss

    posted this information here https://www.tinnitustalk.com/threads/igf1-insulin-like-growth-factor-1-as-sshl-salvage-treatment.16310/ I'm in the process of sourcing IGF1, I made contact with some doctors, Clinic and compounder to make a custom IGF1. Will post up my progress as I do, at the...
  37. XDR

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Yes acute sensorineural hearing only at this stage. I'm going to try this myself using HGH or IGF1 if I can get a hold of it. Actually I'm starting to think tinnitis and hyperacusisis cause by defects in the veins and arteries. I'll write up my full thoughts and reasoning in another thread but...
  38. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Old paper RE: Mecasermin http://www.ncbi.nlm.nih.gov/pubmed/19198769 'Other applications that have either been considered or are undergoing clinical trial are based on the ubiquitous tissue-building properties of IGF-I and include chronic liver disease, cystic fibrosis, wound healing, AIDS...
  39. XDR

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Snake oil, there are a lot of Cowboy clinics, don't go near it. Taking fat and re-injecting it back into is not research or valid science. I'd wait for definitive proof, best case you've lost a lot of money, worse you get a condition much worse. there is research in the fields from real...
  40. XDR

    IGF1 (Insulin-Like Growth Factor 1) as SSHL Salvage Treatment

    Hi All, I found this site quite informative so I thought I would give something back. I've been looking at the literature recently about SSHL, to me all the possible drug candidates look inconclusive (eg AM101) and Gene Therapy is way off in terms of development...