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I only saw part of the webcast. Did they indicate why they think FX-345 may help a broader range of patients?

Let’s hope so.

The waiting does indeed suck. However, to the best of my recollection, FREQ has been pretty much on the spot with releasing data/results when they say they will. So "end of the first quarter" will be one of the last few days of March.

I respectfully disagree. I think the last President/Administration did in fact facilitate the COVID-19 vaccines by ensuring those drug companies (Pfizer, Moderna, Johnson & Johnson) had all the resources they needed. I'm sure they went to the head of the line anytime they needed the FDA's...

Holy Smokes! Thank you for all of this. Do you ever sleep!?

Profit taking going on. Investors/speculators getting cold feet.

When the share price reaches the stop-limit price you set it triggers the sell or buy order but does not guarantee the execution of the order. So yes you need a buyer if you are a seller and vice versa. FREQ is still a highly speculative stock, though I do own a few shares to keep me interested.

I thought the opposite. I was thinking the recruiting is taking longer than they anticipated (the previous phase albeit smaller numbers went pretty quick). Maybe they are adding sites to help fill out the trial more quickly? Pure speculation here, but is there an advantage to expanding the...

I applied last phase(1b) and was denied. Unfortunately for me, the same parameters apply this time (stable sensorineural loss, not me) so I won’t qualify. It would be nice just to hear that some folks around here are actively participating in their recovery and know that at some point in the...

I've been following this thread off and on for quite some time. And I really do appreciate and enjoy reading the different insights from everyone which carry both hope and pragmatism. I do tend to oversimplify things to a fault sometimes. And at risk of sounding like a weather forecaster hedging...

Could you kindly refresh my memory please as to when and where they will release their results? Their website references a “major otolaryngology event in 2019”. What event would that be?

Thanks for the reply. I am familiar with Frequency Therapeutics and the study. I guess what I was asking was that they announced somewhere and I missed the fact that there was just 2 (or a few patients) with positive results. Hoping it is more like “most” or “all” patients saw some level of...

Just curious. Where did you see that 2 people had positive results. I must have missed that somewhere along the line.

I exchanged a few emails with Dr. Shim and even sent him my most recent audiogram. He quoted me $9,000 per ear. For mild cases he would use blood only but for moderate to severe cases he wants to use bone marrow as well. I have profound loss in one ear and moderate loss in the other ear.

If only that were the case. You're probably missing 2 zeros.

I recently emailed them expressing my interest in their work and that I have been following it for some time in hope of getting some type of update that is not available on their website (knowing I am from the US and not eligible). Wishful thinking, I know. They essentially replied... what...

Seems like funny math to me.

Let me start by saying I sincerely hope their claims are legitimate. as I could be a benefactor. Reviewing the many posts on the thread one can see they have been claiming success for quite some time. But why the slow progression to human clinical trials? If memory serves me, I believe most of...

Haven’t heard a peep out of Stanford in ages

How about speech discrimination? Which is a whole lot more important and complex than just hearing sounds. I pray they found some level of success in restoring the ability to hear sound and understand the spoken word. You can’t test that on a mouse (pretty sure) which is my point. They claim not...

d'Wooluf I have to agree with you. I do not want to discourage people from sharing news and asking provocative questions but rampant, unbridled speculation is not helpful. Nobody, not even the founders of FX-322 knows if this "works". They gave the drug to 16 people. Unless they have figured...

I don’t believe so. They are in phase 1b right now and it is filled up. Phase 2a tentatively planned to start in the latter part of 2019, I believe. I don't know if being a US citizen is a requirement.

Do you mean he did not participate in the trial? Or that he received the placebo?

Aspartame... an artificial sweetener... used in Diet Coke, etc... not real good for humans... I believe the lad is being facetious.

That’s what I’m hoping for. I’m assuming the group they are testing now in the trial are those they believe would most likely benefit. If it is successful they broaden the study a wider range of people.

I haven’t heard of Akous but I have heard of Spark Therapeutics as they are near Philadelphia. They did treat a boy with a gene therapy for his eyes that has been effective. I believe they charged a mere $425,000 per eye.

They declined me as well saying they need people with noise induced hearing loss. I didn’t know that could be determined just by looking at an audio gram. Is that even possible?

The receptionist, Lauren, from Alamo ENT, who I spoke to regarding the trial replied to me. Read into what you like. Seems pretty plain to me. The trial is underway and treatment has begun.

Yes. So it appears this study is marching right along with plenty of volunteers. She was not sure how many they intend to treat.

Just sent Alamo ENT a few audiograms, waiting to hear back. The receptionist said they are receiving plenty of interest ( 8-10 calls a day). They have already treated 2 cases. Let's hope for positive outcomes.

Philly Philly

Frequency just posted that they successfully completed safety/efficacy trial in Australia. Check their Twitter feed!

Anyone know if Frequency completed there small safety trial in Australia ?

I second acufenero's opinion. Additionally, don't ask me to post the data (it is buried here somewhere in a thread) the preclinical data results regarding simply the volume of inner ear hair cell regeneration by Frequency blows away Genvec's approach. And the chap from Kansas that we know of...

Does anyone know how long they anticipate it takes the cells to grow after a treatment ?

I'm just as eager as you are to give them my money if they could "turn back the clock" a few years. Pretty sure they're just as happy to take it

Does anyone know if "they" (Frequency TX and the like) have the diagnostic ability to determinine the amount of supporting cells?

The way I understand it is that Audion's method causes your existing supporting cells to differentiate into hearing cells whereas Frequency's method promotes formation of new supporting cells followed by differentiation into hair cells.So would have fewer supporting cells after Audion's method.

I am wondering if participants are allowed to discuss their results (good or bad) from the treatment prior to Audion releasing their findings. Anyone have any insight?

At the bottom of the blog it says another blog coming out end of month from researchers/clinicians running REGAIN trial which will provide more info regarding how you can take part.

Apparently I have been living under a rock. With all the time I spend online reading about hearing loss(research) I don't know how I missed the REGAIN PROJECT. Brightens your day when you see news like this.

Samir... at the :55 second mark the reporter states it not Luchinno

I would like to reaffirm Aaron123's reply (he is usually spot on) as to Frequency's approach of ample progenitor cell division before differentiation. So, I believe,they are not going to "use up" all of the supporting cells. I tend to oversimplify things (sometimes to a fault) but in reading...

@ Samir Still trying to get my head around this whole thing. But I do recall reading something from Stefan Heller where he said after promoting new hair cell growth the nerves have a tendency or appear to attempt to reattach.