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My understanding is it would reach 5 kHz and frequencies above. You have hearing loss above 5 kHz. You may not realize you have hearing loss because you haven't been tested to 16 kHz or 20 kHz but at least somewhere in the 20 kHz range some of your hair cells have died.

Fair enough. It's just my view that the commenters can view different companies maybe not equivalently. I'm specially talking about all the love Decibel Therapeutics was receiving back in 2017/2018. They were taking in ton of cash yet had no interest in human testing on the horizon and were...

I disagree with that assessment. Talking the talk would be more like promoting their product to investors and never testing it. Frequency Therapeutics injected people in their trials aka they tangibly did something.

Sorry if I missed this but did Frequency release a before and after test subject audiograms for the 8 kHz-20 kHz range? Personally, I'd love to see a large data set (say 800 patients) of before and after audiograms, particularly for the 13 kHz-20 kHz range.

So if the trial recommended limitations translates to the designed population, this device doesn't make sense. The device isn't going to improve you structurally so even if you start using the device in the acute phase over time you will have tinnitus for longer than a year. I've been a skeptic...

This is a result of the brain being so complicated that science still has a limited understanding of its underlining processes. This doesn't worry me for hearing restoration because while the ear structures are very tiny and inaccessible the mechanism for hearing is so simple an elementary...

Unless there have been updates on imaging you'd have to go through dissection of the ear preferably during an autopsy. FMRI techniques might provide an imaging solution though it will take minimum 6-20 years to improve to that level.

Thanks. Yea I get that NDMA isn't regenerating anything but I'm curious if someone could have some connected synapses that have no/reduced functionality but with say with this drug and its reduction in environmental inflammation mean a handful of said synapses become or improve in signal...

Has it been proven that there is no underlying structural improvement with this treatment, even very slight minor repair.

Can someone remind me their current plan/timeline assuming a successful Phase 2a. Will they go to a Phase 2 or 3? When would that next Phase take place and how long would it last?

More like: Susan Shore (5 years from now): "Our Phase 2 trial has been delayed 2 more years because (insert made-up irrelevant and vague excuse here), Also this device is not yet commercially available for "reasons"." World: "Tinnitus has been cured" Susan Shore: "Thank God. Now I don't have to...

Can someone summarize what we know about OTO-6XX?

ENTs solve problems??? Could have fooled me. That statement is mostly true, I get that on rare occasions they will surgically remove tumors.

Yea agree. The minutes response more between their own employees. The main point is that even though they aren't in the lab all employees need to be working tirelessly (labor laws be damned) to communicate their findings within the next couple weeks.

There is absolutely no excuse for not drafting a paper on the results due to the coronavirus. With the stay at home order they should be posting the paper well ahead of schedule. Also these scientists have email access from their homes and should be responding to emails within minutes.

Regardless of hearing protection it is too risky for your ears to shoot a firearm ever again throughout your life. The only caveat would be if you or a bystander is being attacked by a knife and your life is threatened then sure shoot away.

You meant kHz right?

@Tweedleman Nah take handfuls. Just bench a ton to prevent man-boobs.

This company's management were dogshit con-artists from the start. F them and their former sleaze-bag CEO for wasting all that investor money.

Acknowledging that all life eventually has an endpoint is not cruel it is simply self-aware. No one is immortal. Understanding that fact is part of being human.

That's not a given. Have you heard of Enron? Also investor dollars toward this company could be less money going to others in the regenerative hearing loss field. Not great in the short run.

That's a question for us but not a showstopper for the company. If they've improved your hearing and that improvement remains then you've got better hearing for your lifetime or until new noise damage. That's the definition of a value added drug.

True but for this company their priorities are designing an aesthetically pleasing work space and raising money from investors via fanciful sales pitches, said "pretty" workspace, or pedaling some useless oto-protective treatment to grab more investor money. They have not shown any interest in...

Right but is PIPE-505 dividing the supporting cells?

That's the answer I was afraid of.

Would treatment with this product limit the effectiveness the future use of Frequency's FX-322 product. Aka does the increase in ATOH expression use up supporting cells?

One what does it matter if Freq is not yet approved by FDA but approved in Euro or Asia. It would be available somewhere where a person could travel to. And why do you think Freq which has gone from Stage 1 to 2a in less then 3 years would take longer to get to Stage 4 then a group that has been...

I hadn't heard that noise produces a chain reaction which results in DNA mutation. Has this been confirmed elsewhere. How does this exactly work? Has this been proven and to what degree? Can someone elaborate??

Did any of these 15 people measure above 8 kHz? If not through Frequency Therapeutics, then independently on their own? If so what happened between 8-16 kHz???

We don't necessarily need imagining technology although that would be very helpful. All the study would need to do is apply the compound to one ear only, wait for said individual to die, and then dissect that person. If there is a big difference between the nerve connections from the treated ear...

If you don't mind me asking, what is your dBa loss at 8-16 kHz?

That's probably not what they fear. What they are likely worried about is the objectiveness of tinnitus patients. Since there is not yet a way to measure numerical tinnitus without talking to the patient it adds some uncertainty for the company. That being said since this drug likely will help...

It's not testing on me I'm worried about, it's all the other people who will be turned away and the resulting lack of data/information that will follow from their exclusion.

It sucks that tinnitus is an exclusion for their clinical trial.

Please stop commenting on this thread. Whether or not timing is effective no device will ever be made from this "Work". We should all move our focus to groups who don't waste time and thus are more likely produce.

Is it just me or did Decibel Therapeutics go backwards? This company is a waste. They have incorrect priorities. At this point I only hope they don't clog up the research feed touting how much money they've received from investors.

Doctors who preform CI surgeries have first hand knowledge of the ear. So I wouldn't immediately discount their information, especially if it relates to the structure of inner ear.

Just move to LA, SF, or NYC to buy one so you can sit in it in gridlock :D

Not really if certain parts of the day are more important than others

What frequency do you have 20 dB and 40 dB losses at?

@Roadglide I'm assuming you get to keep the wires attached after the study is complete or do they require that the hardware be remove?

Understood. Still even if the people in the studies all had hearing loss below 8 kHz it would be useful if Frequency measured the before and after hearing both above and below 8 kHz.

This is the one near term thing Otonomy is doing that I'm very interested in learning the results. Honestly people on this site should be a lot more interested in these nerve targeted products. Shame on all the members here for missing an untapped and less complicated target for new drug...

Very well then the "University system" does not work full stop.

While I understand them not talking to the avg joe I just don't buy that they have been using time effectively. They have delay trials for years simply because they couldn't garner the necessary funding. Between 2010-2019 there have investor flush with cash ready to bet on even long shot...

How far is that ABC station broadcasted? Just 30 miles from Boston or does it cover all of New England?

Any speculation on the cause of the move??

If anyone knows the reason for this date slippage please post to the community!!!

It's not just your hope that is concerning; with their glacial pace of development I could see a Chapter 7 for this company on the horizon.

https://www.decibeltx.com/pipeline/ Their pipeline confirmed what I had been saying "that they are wasting too much time on ototoxity therapies and lab construction rather than focus on therapies that will benefit the most amount of people". (n) However it is nice to know after they get...

Why you might think that's the best approach the term treatment is being misappropriated. That approach is best characterized as a behavior adaption. Part of life is trying things out and see if they work. If you not emotional able or emotional prepared to handle lack of success then you're...

Yea I kinda mentally gave up on this when I learned they started pre-clinical prior to 2013

Oh. Yeah I had already written OTO-313 off as useless for long term Tinnitus. Very interested in the results of OTO-413 though.

Explain why this matters?

Did your hearing get affected by the hole/healing/scar tissue? Any additional high frequency hearing loss due to the injection?

Even if FX-322 works creating new hair cells and neurons; no person is going say they don't want repairs and addition neurons to legacy haircells connections

If used properly it's an indicator of hearing loss when compared to the predicted high frequency hearing of the patient's age cohort. That information could then be used to change behavior or to prescribe vitamins/earplugs/hearing protective NAC etc. This could and should be standard...

Are you sure on that timeframe? Any reason they couldn't start phase 1 in say 5-7 years??

Is the ERBB2 a novel pathway from Frequency's drug trial? Who/when is testing the "two drugs, originally developed to stimulate stem cell activity in the eyes and pancreas, that are known activate ERBB2 signaling."?

None of these delays surprise me with U-Mich. They have been unreasonably slow given they started work in the early 2010s. Don't worry too much if they are too slow they will be beat to market.