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Science Magazine Recognizes Frequency Therapeutics’ PCA Regeneration Technology as a Breakthrough in Regenerative Medicine https://www.businesswire.com/news/home/20180320005327/en/Science-Magazine-Recognizes-Frequency-Therapeutics’-PCA-Regeneration

Frequency steals Otonomy’s CSO: https://www.businesswire.com/news/home/20180312005344/en/Frequency-Therapeutics-Welcomes-Otonomy-CSO-Executive-Vice “Since I’ve been monitoring scientific advances in hearing regeneration over the last decade, I consider Frequency’s PCA Regeneration platform a...

I don't think OAEs measure above 8k, just like standard hearing tests. Mine didn't anyway. Listen to a frequency sweep on low volume on decent full range headphones or speakers and see what happens at the higher frequencies. Probably some hearing loss there

Three-way Collaboration with the U.S. Army, Harvard University and Frequency Therapeutics to Focus on Progenitor Cell Regeneration in Muscle http://www.digitaljournal.com/pr/3660478

You're thinking of auditory neurons. Synapses connect hair cells and neurons, they necessarily die when hair cells do.

Synapses without hair cells are not possible. They are connecting fibres. If a hair cell goes, its connection to the auditory nerve goes.

My hopeful speculation (based on nothing) is that if these deafferented hair cells are near to missing hair cells, the regeneration process might release neurotrophic factors or other signals that cause these to re-synapse as well. :whistle:

I'm hopeful that restoring input (by regenerating hair cells in the case of FX) will alleviate hyperacusis as well as tinnitus. I think it's very telling that a high dose of sodium salicylate (aspirin) induces hyperacusis and tinnitus as well as moderate hearing loss by disrupting hair cell...

I guess that there is not a straightforward answer because it depends on the toxin. Some drugs may destroy just the hair cells, in which case FX-322 will (theoretically) work, some may destroy supporting cells as well, in which case FX-322 will have no effect.

As far as I understand it, the dead cells are cleared away/reabsorbed by the body and are no longer present at all, so regenerated hair cells will be in their place not "next to" dead cells...

I think this may be a misconception about how hair cell damage causes tinnitus. It's likely that the brain amplifies frequency bands where there is reduced signal, i.e dead hair cells/synapses/neurons. So your perception of ringing is not necessarily evidence that hair cells are "alive and well"

I guess that's like asking how tinnitus goes away along with hearing loss associated with a high dose of aspirin, or how it goes away after emerging from a soundproofed booth. The brain is producing the sound but when input is restored the brain stops doing this. I'm sure that there are a few...

4. Aspirin at high doses, which causes temporary moderate hearing loss, also causes temporary tinnitus (and hyperacusis): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341117/ 5. Most people experience tinnitus after spending a few minutes in a soundproofed room, presumably due to lack of...

https://www.theguardian.com/science/2017/dec/20/breakthrough-for-genetic-hearing-loss-as-gene-editing-prevents-deafness-in-mice

No new information really but here's a podcast about Frequency:

Not much in the way of new info but there's a new Bloomberg video segment at the bottom of this page http://www.frequencytx.com/community/community-resources.php

Yep, fair enough, I'm just bulletpointing what he said

- They will be releasing a new paper with "data that will continue to capture the imagination of the scientific community" - They hope to have something on the market in 3-5 years - "Favourable interactions" with the FDA, so far

“We expect to be in the clinic within the next 12 months” Timeline proceeding as it should :rockingbanana:

Does anyone know if it's possible for stereocilia to be damaged by noise but the cell structures themselves live on, despite this damage? I hope not, as I worry that the distortions I have in my hearing may be because of damaged rather than lost cells (that could potentially be replaced with a...

I didn't know that. Is there research showing that milder hearing loss is all outer hair cell damage, with all inner hair cells intact?

I am really happy that Phase II is scheduled to follow Phase I so quickly, bodes well. The race is on

Good to see a report like that on Frequency Weirdly worded statement from the voiceover though: "We are born with the exact same number of hearing hair cells as we die with" ... ummmm no!

Here's an interesting exchange I recently had with Will McLean on reddit: As I understand it, the gel you are working on is designed to activate dormant progenitor cells in the cochlea, activating them to differentiate into functioning hair cells. Will the gel only activate supporting cells...

Excellent. They're the real deal

I'll take it lol

A bit more good news. I got in touch with Will McLean and asked him: The findings that have been published so far involve cochleae removed from mice, primates and a human. I see that in 18 months there will be live human trials. Has there/will there be data from live animal experiments prior...

Well he posted: "I am founding a science company based on my research. I will be a co-founder and the person conducting the experiments" two years ago. He mentions having a PhD in stem cell research and seems quite young. I think it's Will McLean

From Frequency's website: Dr. Robert Langer is an award-winning Institute Professor at MIT. He has written more than 1,350 articles and has over 1,100 issued and pending patents worldwide. Dr. Langer has launched over 30 companies and his patents have been licensed to over 300 companies. He is...

Holy moly, look how many honorary degrees and awards Bob Langer has: http://web.mit.edu/langerlab/publications/RSL-CV.pdf

Yep, bit of a worry. I could imagine extra hair cells springing up in various areas causing worse tinnitus/hyperacusis due to distorted over-emphasis on certain frequencies

I can't think that a gel injection to the middle ear would cost thousands. But even if it does, I will never have put together so much money so fast haha!

Another question... Don't the supporting cells next to healthy non-damaged hair cells also get activated and generate extra hair cells, and what would the effect of that be?

Direct those questions to the hyperacusis support page: https://www.tinnitustalk.com/forums/support.55/

Samir posted a summary of correspondence he had with Dr McLean a couple of pages back. On this point he said: The hair cells they make in a dish show that they have all the characteristics to function properly. They have long bundles, function electrically, and make the synapse components to...

I'm not sure... it probably can be nerve damage instead of/as well as hair cell damage. Anecdotally I find it a bit coincidental that my hyperacusis is a tad worse in my right ear than my left and that's the one that performs worse on an audiogram. I think when people produce "perfect"...

Thank you. Ok, that makes more sense, so the molecules in whatever gel they make will target existing supporting cells and the resulting hair cells will be in the right positions. I hope that particularly bad noise traumas do not also damage the supporting cells and therefore prevent them from...

I also have some questions. I think I may be seriously dim on all this but I’m not clear on the following: - Has Langer and Karp’s research demonstrated hair cell regeneration in live mice and primates, whereby their restored hearing was observed, or simply in cochleas removed from their...

I’ve been keeping a Word document with every hopeful thing I can find, and Frequency Therapeutics is one of the only developments keeping me going right now. Sorry to repeat previous info but this is my summary of very encouraging things: - The $32 million funding round. That’s a pretty...

I am hoping that treatments repairing hair cells and/or neuronal connections make speedy progress and that these will address our symptoms...

Thank you SilverSpiral and PaulBe, that's really good to know that I'm not the only one! Do you have measurable hearing loss? I guess this particular pathology makes sense in that our auditory systems are accentuating frequencies due to lost hair cells...

I'm curious to know whether anyone else experiences tinnitus in the same way as me, as I've yet to see it described. I have noise-induced hyperacusis and tinnitus. I do have some "traditional" tinnitus, i.e steady-frequency ringing in my ears (although different tones in each ear) - but this is...