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Subsonic ammo and a suppressor will be staple gun quiet. Add hearing protection on top of that and it will be very quiet. Now shooting around others there is no guarantee. Wear good muffs with a high NRR and foam earplugs at a minimum.

You probably have the standard 4 kHz notch that many people get. The ringing is hyperactive nerves making up for the loss off signal. Usually the ringing is at a frequency just above the loss at least based on my research.

I just ignore it less. I think some of it is real (the tone is really there) and some might be my hearing.

She won't. My bet is the University will likely look for someone to license the tech to that will commercialize it. Notice on the last page "Product Launch Strategy - To be determined by licensee". Commercializing and manufacturing a product requires a completely different skill set than...

A hair cell is a hair cell and there is no fundamental frequency response difference between cells. However, the location within the cochlea determines its frequency response. The outermost cells being the highest frequency and the most inner being the lowest. I don't think there is any...

I'm speaking on as to how their respective drugs worked in the lab. Frequency Therapeutics is trying to expand the number of LGR+ progenitor cells and then converting those to hearing cells using additional drugs in their cocktail. Regain is not doing any sort of expansion. Both utilize a...

You are assuming both will provide equal results. The literature suggests FX3-22 “cocktail” of small molecules will produce better results than REGAIN’s sole use of just a gamma secretase inhibitor. How this translates in vivo for humans we don’t know yet, but I think your conclusion that...

Yes, but premature loss of those frequencies (8-16 kHz) would be an indicator of hearing loss and could warn people to start making lifestyle changes before it gets to the important frequencies.

Yes, there is a delay of about approximately 10s to 100s of milliseconds before it comes back.

Your average Dr. practicing medicine in a clinic or hospital is just a product of the medical education system. They are taught the literature on symptoms and approved treatments. They don't have the time or resources to innovate and advance treatments that require heavy lifting like tinnitus...

This is pretty cool. Hopefully the only side effect is increased happiness!

In the United States it is now the first to file for a patent that gets patent protection. It used to be first to invent, but that changed several years ago. So this is likely the rush to patent regardless of how well it works. I don't think it is a rush to produce a junk device. Filing a...

The difference in pace is clearly pure market capitalism vs a government grant. Where did you see 2020?

Thank you for posting this. I know first hand that T frequency and hearing loss are perfectly correlated. Wherever I have a notch, there is T right above it.

Elon Musk knew nothing about rockets 20 years ago, but here we are today with the most cost effective solution to putting things into space with SpaceX.

I have multiple frequencies of T. I have a 13kHz hiss and a 1.56kHz ring in the right ear. Both of these are modulated by different parts of my face. The 13kHz is louder when I clench my jaw or tilt my head to the left. The 1.56kHz is increased by stretching my back muscles like when I yawn...

Can you ask them if they are considering this? :-)

@kelpiemsp can you ask them if they plan on treating multiple tones? Suppose different tones in each ear or multiple tones in the same ear.

This trial is simply a risk reduction trial from a business standpoint. Call it whatever you want for the FDA, but there are unofficial trial endpoints that will drive whether or not Frequency moves ahead on this in future trials.

Did they state why it needs to be above 3 kHz?

6db is double the amplitude, not necessarily the volume... http://www.sengpielaudio.com/calculator-loudness.htm

This site has tones you can play at 10db intervals https://www.audiocheck.net/testtones_hearingtestaudiogram.php

Doesn't sound like much when you listen to it at full volume, but when you play it at a low volume you can definitely see how 10db could push a lot of people's T into the background of their hearing.

White noise would be noise across all frequencies.

Be careful by just saying it takes xx db of sound pressure to mask your T. It really depends on the spectral content of the noise. If you have 13khz T it is a lot harder to mask than 1khz because of the frequency spectrum of the noise sources. Download an app like Decible X and look at the...

Great news. So 7-10db would imply that it’s about half as loud as pretreatment. Is that about what you estimate?

If support cells are there I think it will help. Frequency response is dependent on location in the cochlea. Basically it is sort of like a coiled up piano. A support cell is a support cell regardless of location.

Yes once it gets bad enough.

It is a bit concerning I see no listing on the clinicaltrials.gov website for this Alamo trial. It just shows that the Phase I was completed. It isn't clear how they are doing this without a registered trial.

I find it interesting they say that it is located at the "Phase I Unit". Not sure if this is just the name of the building that gets used for a lot of Phase I work or are they doing more "Phase I" work before moving to a costlier phase 2.

I believe many cases of tinnitus "without hearing loss" is actually tinnnitus with hearing loss. You can actually get very narrow notches in your hearing that sit right between the hearing test points. I know firsthand. Also, most places test to 8kHz which I think is a mistake because testing...

Hi All, Last night I got a new tone in my left ear. My left ear has always been pretty good. My right ear has had the 1.56kHz tinnitus. Well now my left ear has it at 1.26kHz and it is louder than my right. It also had a plugged feeling and there is a notch there now. I'm not sure what I...

Where did you hear out hair cells are only 5% of the population. Everything I've seen suggests 3 outer hair cells to 1 inner hair cell. Look at the cross section of a cochlea. https://ars.els-cdn.com/content/image/1-s2.0-S037859551630260X-gr1.jpg http://www.cochlea.eu/en/hair-cells

Frequency is likely using it in their FX-322 based on their prior published papers. LY411575 is also the most potent Gamma-secretase inhibitor based on some literature I read. I believe the doses they gave to Alzheimer's patients were extremely high compared to what they are using for hearing...

This is the company that is tied to Hough Ear Institute: http://otologicpharmaceutics.com/

10db is considered twice as loud. Some will argue between 6-10dB.

Where did you hear this? Source?

Definitely good. The rubber meets the road when they do human trials though. Sometimes things don't work on humans that worked in other animal models. Exciting none the less

He comes from Eli Lilly. I believe LY411575, the most potent (that I'm aware of), gamma-secretase inhibitor is made by Eli Lilly and is what Frequency is using in FX-322 based on published papers.

I also think it would be worth gathering data for members here about tinnitus frequency among other things. Everyone here has tinnitus, but rarely do they state the frequency(s), age at onset, age at disappearance. Just make it part of the deal of being a member here. It would be good for...

~10-13dB recovery through direct differentiation of support cells. Not too bad. That's a bit over a 2x improvement in hearing thresholds.

I've been thinking about this more. Supposedly a lot of people age and never experience tinnitus. First, keep in mind I'm sticking to the wikipedia definition of presbycusis: "The hearing loss is most marked at higher frequencies. Hearing loss that accumulates with age but is caused by factors...

@Aaron123, were you going to buy a copy of it?

Hopefully guinea pigs means humans are next. Hough has been working on this for awhile. This is from 2012. http://houghear.org/wp-content/uploads/2012/03/Du-Kopke-Regeneration-of-mammalian-cochlear-and-vestibular-hair-cells-through-Hes1-Hes5-modulation-with-siRNA.pdf

I wish there was a cartoon of this. So the LGR5+ support cell divides through wnt signaling, the resulting new cell converts to a hair cell? This is different than the use of gamma secretase inhibitors which cause direct trans differentiation through notch? I'm still a bit confused because...

Aaron, have you seen anything in the literature about whether the Lgr5+ cells convert directly to hair cells after division or does another molecule convert them? Just wondering if any Lgr5+ cells would be left after the FX-322 treatment? I haven't seem them comment on this so far, but might...

Tylenol(acetaminophen) is hard on your liver. You might want to keep that in mind as you evaluate you treatment options.

I've noticed that the hvac at work, bathroom exhaust fan, microwave fan, refrigerator and even white noise from driving in my car seem to cause this randomly pulsating tone/chirp at ~1.2kHz in both ears. The hvac at work is the worst because there are lots of blowers in the ceiling and other...

Don't Die. ;) I've heard similar to what face2black said.

I believe this a similar drug to what was used in this paper. https://www.nature.com/articles/srep24907

That's $3,000 per ear if I'm doing the math right...

ACRN was based on a poor understanding of the root cause at the time. Also the studies provided poor evidence that it even worked. https://www.frontiersin.org/articles/10.3389/fneur.2017.00036/full The brain can be retrained in some ways, but when the source of the ringing is hyperactive...

Disagree. The rarer the disease, the more expensive the drug. The market for hearing loss is huge. They could sell it for a sky high price, but only sell it to a few people, or they can price it lower and sell to more people. In the end they will find the price they believe maximizes their...

This is great news! Hard to tell how the contraption works. Looks minimally invasive? However, is the treatment permanent or do you have to continue treatment to maintain the reduction in loudness?

My audiogram is normal. However if I do a test in my closet using the tonegen app on my phone I find there is distortion at very low volumes at frequencies below my T. I can still hear stuff there but the tones sound very off until I hit a certain volume. I don’t think the std hearing tests...

Try these for the movies. They cut everything down, but still allow you to have normal conversations vs. the foam plugs. https://www.amazon.com/EarDial-Ear-Plugs-Comfortable-High-Fidelity/dp/B00P2NTVPA

By the pictures it would appear both inner and outer cells.

Agree that it will be organized, but look at Figure 7c compared to treated 7d myo villa The inner cells, went front 1 to two in a row and outer went from 3 to to ~6 in a cross section. 7e shows a nice treated section where you can count...

It would be interesting to see what he thinks about overpopulation of hair cells. If you unroll the cochlea so its like a piano, the inner cells are in a single row, while outer cells are in 3 rows. Based on the lab tests they got a lot of regeneration and I wonder how the brain will respond...

PM me if you need some help. I've read both your posts and I think you and I have quite a bit in common. Its still a battle for me every day. Heck I went 6 months before I even figured out what it was and since I figured it out what it was its been really hard.