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I disagree. Of course, you need to keep a rational, grounded outlook. None of us here will be cured in the next 5 years, but every step gets us closer to our destination.

I’m not sure what you mean by this. Do you mean acquired hearing loss? Doesn’t this simply mean that the individual lost their hearing after birth?

I’m not entirely sure I understand this. Hypothetically, if someone has hearing loss where 50% is attributed to genetics and the other 50% to noise exposure, and assuming the drug works perfectly, does that mean it can only restore 50% of the lost hearing capability? What other types of...

You know what else hurts? I still think FX-322 wasn’t a complete failure, they just needed more time and research but unfortunately ran out of cash. *sigh* hang in there dudes. One day...

TL;DR: 2023 is do or die for Frequency Therapeutics. There is something here but the results haven't been as consistent as desired and there are a ton of questions remaining. They only have $111M left in cash and operating expense were $98M last year. If it doesn't see strong enough results to...

Scientists from King’s College London, the Karolinska Institute, and Erasmus University have recently discovered ten additional genes connected to hearing loss, and located the part of the ear affected. The results, which were published in the American Journal of Human Genetics on May 16th...

Does anyone have insight on the state of Frequency Therapeutics right now? I have been seeing a lot of new articles out there but no new information, possibly suggests they are on a media campaign to try to revive a company in decay. I also heard rumors they had to lay off a bunch of staff...

Summary of this morning's presentation: Encouraging results and they seem to have something here and be on the right path, but it is not a "golden ticket" at this time, there is much more work to be done but there is justification to be optimistic. One of the biggest hurdles is delivery of the...

More information --> Additional information link https://www.clarahealth.com/studies/hearing-study Another thing Exclusion Criteria: Evidence of or previous diagnosis of auditory neuropathy, traumatic brain injury, "central" hearing loss, or "genetic hearing loss". Is that not incredibly...

Clinical Study Sites New York, New York New York, New York (Actually NJ) Albany, New York Amherst, New York Richmond, Virginia Norfolk, Virginia Winston Salem, North Carolina Novi, Michigan Cincinnati, Ohio Orangeburg, South Carolina Charleston, South Carolina Milwaukee, Wisconsin St. Louis...

Exclusion Criteria: 1. Subject has previously been randomized in a FX-322 clinical trial. Conflicting information?

Anyone watch the presentation this morning? Can anyone give a summary? Anything new?

Noise-induced hearing loss Age-related hearing loss Antibiotic related hearing loss (ototoxicity?) Viral/bacterial related hearing loss Congenital hearing loss (genetic?) Other types of hearing loss? What are the odds that FX-322 works for some but not for others?

I just want to throw this out there. I had probed into the Phase 2 clinical trials and the following came up: - "The trial was looking specifically for people who had significant dips at 4 kHz to 8 kHz on their audiogram. They did not say if a specific baseline was required for frequencies...

I'm having trouble interpreting this. Can you link the tweet?

I suppose the focus should be on compassionate use access?

What's the best way to do this?

Guys, do you think there is anything we can do collectively to try to get expanded access/compassionate use offered ASAP? I'm the type of person who has been googling Frequency Therapeutics everyday (literally every fucking day) for every single update for the past 4 years. I unfortunately...

Regarding Radial, this is the academic article that sticks out the most: Radial communication between the perilymphatic scalae of the cochlea. I: Estimation by tracer perfusion And what do you mean by "flaws"? Flaws regarding coming to conclusions using an audiogram as a test in general? Or...

Today's presentation: "We are getting quite a number of questions regarding tinnitus"

Is there a serious opportunity for compassionate use? Would you have to make an appointment at their HQ in Massachusetts? Did you just call the number on their website?

Is this something that is a concern for human trials? I thought they were doing multi-dose trials on humans right now. Why would that matter for animal studies but not human? Or is it a concern?

Perhaps people here are interpreting this as "the year 2023 is when FX-322 will reach pivotal trials" when the actual meaning of it is "Frequency Therapeutics has the capital to sustain itself well into 2023 regarding pivotal trials for all of its products, including Multiple Sclerosis and other...

Frequency Therapeutics plans HQ move for early next year More positive news.

MIT Scientist Bob Langer Becomes A Billionaire Thanks To Moderna Stock Rally

So at the end of Q1 2021 we will see a simple before and after of their results, and at the end of Q2 2021 we will see a report after each injection and (hopefully) the steady improved hearing results coinciding with each injection?

https://www.businesswire.com/news/home/20201116005184/en/Frequency-Therapeutics-Provides-Business-Updates-and-Reports-Third-Quarter-2020-Financial-Results What's the difference between "Analysis of Day-90 Data" & "End of Study Readout" which are to be completed Q1 and Q2 respectively in 2021?

https://www.bloomberg.com/news/audio/2020-02-19/baystate-business-politics-and-fish-radio Bloomberg Radio, starts at 7:06, haven't gotten a chance to listen yet, will when I get home.

https://investors.frequencytx.com/static-files/6d161090-16f5-49f4-9606-8caceb5a88a1 Presentation link.

News: https://www.businesswire.com/news/home/20200107005231/en/Frequency-Therapeutics-Present-Business-Pipeline-Overview-38th

*PSA & Update* The trial is specifically looking for people who can pinpoint the event in which their hearing loss occurred (and I suppose it is thus heavily implied only people with NIHL are eligible for this phase). You will only be eligible for this trial if you can say something like...

PSA: If you are participating in this trial, you will need to make at least 12 trips to the testing center, possibly more. Additionally, you won't receive more than $700-$900 as reimbursement for participating. As someone who lives in the northeast, I was interested, but these facts...

Do you know why? Did they reject you because of something you said? Or because of your audiogram?

Phase II Locations: Fresno, California Torrance, California Colorado Springs, Colorado Boca Raton, Florida Sarasota, Florida Tampa, Florida Louisville, Kentucky Omaha, Nebraska Matthews, North Carolina Winston-Salem, North Carolina, Orangeburg, South Carolina San Antonio, Texas

Am I misinformed? Because I believe this is a lie. The first round of IPO is only available to major institutions, Goldman, Morgan Stanley, etc.

Wayyy too much pessimism in this thread, people think that just because there wasn't an immediate improvement in audiograms means the drug isn't effective. This conclusion is not sound. Let's say the average audiogram test has a variation of 15%, and then let's say the dose given (a small dose...

https://finance.yahoo.com/news/frequency-therapeutics-expands-leadership-team-123000568.html Two more very intelligent people joining the Frequency Therapeutics team. As a man with confirmation bias, I am interpreting this as excellent news.

WE GONNA MAKE IT BOIS. KEEP YOUR HEADS UP.

Probably doesn't mean much, but if you look at their website: https://www.frequencytx.com/news-events/press-releases.php You can see they have hired a PR firm, "Scient" rather than media inquires being given a direct Frequency Therapeutics line like before. As someone suffering from extreme...

https://www.wsj.com/articles/fast-track-drug-approval-designed-for-emergencies-is-now-routine-11562337924 "Fast-Track Drug Approval, Designed for Emergencies, Is Now Routine Three-quarters of new drugs get an expedited regulatory review, thrusting families and doctors into a new world of...

But then what do you make of the recent trial where Frequency Therapeutics stated improved hearing and word/audiometry scores in patients given the treatment?

For the record, nobody here truly knows the timeline here, this is uncharted territory for the FDA and medical world. Assuming it works, best case scenario is this could be out by 2021, worst case scenario is the FDA wants to take a long time to wait and see if there might be delayed effects...

https://bostonrealestatetimes.com/baker-polito-administration-launches-economic-development-planning-council/ Not directly related to Frequency Therapeutics, but it is nice to know the CEO has some political clout.

On Friday, I called the number on the website regarding clinical trials and gave them my information, the woman who I was speaking to said I would get an email soon. I received the following:

https://www.businesswire.com/news/home/20190404005165/en/Frequency-Therapeutics-Announces-Appointment-Glenn-Dubin-Board Asset management hotshot, net worth of $2.0 billion, I'd like to interpret this as good news. https://en.wikipedia.org/wiki/Glenn_Dubin

https://www.americaninno.com/boston/inno-news-boston/exclusive-meet-the-nominees-of-this-years-nevy-awards/ Frequency Therapeutics being nominated for some award.

Likely nothing is going to be released. They recently had presentations in San Francisco and Baltimore and nothing was released from those either.

They most certainly signed an NDA. I wouldn't break it if it were me. Also, I suspect the participants were given a very small dose, so that even if there were a regeneration of hair cells, it was very few, and it would not be clear to the participant or a hearing test that an increase in...

Lol, wear a suit, rehearse your lines, “Yes I'm a representative from TT Capital” and have some confidence, act like you belong, and I’m sure you could get in.

https://www.businesswire.com/news/home/20190306005121/en/Frequency-Therapeutics-Present-Cowen-Company-39th-Annual Another presentation this monday. Anyone here live in Boston?

Yea, I’ll admit it, I’m one of these people. I don't know about the rest of y’all but I’m going fucking insane. This shit rots your brain. I think I’ll attempt to get into the phase II trial. I feel like I will not be able to live a happy healthy life while I still have this. If this turns out...

Important news: https://www.npr.org/sections/health-shots/2019/03/05/700482545/fda-commissioner-scott-gottlieb-announces-he-will-resign Who ever the new FDA commissioner is could significantly affect the fast track status and when this could be approved.

Anyone got a link? Or a recording of the session?

The thing is though, assuming the treatment works how do they keep this a secret for much longer? How do you keep 12-20? People from letting it slip that a cure for hearing loss has been found for several months? Let's say it was me in the trial, even if I myself did not tell anyone or let it...

I must say, it is a little disappointing. A presentation in SF last month and one in Baltimore earlier this week and neither have been uploaded anywhere online? Phase 1.5 is for the most part completed, I really wish some new information was released.

https://www.businesswire.com/news/home/20190207005590/en/Frequency-Therapeutics-Present-42nd-Annual-Mid-Winter-Meeting Another presentation this Monday, in Baltimore.

https://www.fiercebiotech.com/biotech/decibel-hires-new-cmo-ahead-proof-concept-hearing-loss-studies Best case scenario, Frequency Therapeutics has got everything figured out and no longer is in need of this man's skills and abilities, and he has decided to go to Decibel Therapeutics to help...

Curious, when did you send that message? And to which email address? When I sent an email I was told everything was confidential and we must wait until results are announced.

While we all eagerly wait for the results, I'd thought I'd post this. For those who don't know, Lucchino is the CEO of Frequency Therapeutics, screen captured from his Twitter. I'd like to interpret his retweet as being positive news.