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So it looks like there are other places working on developing drugs to regenerate synapses, other than Otonomy and Pipeline Therapeutics. I guess it’s just a matter of time, although who knows how many years. Well @AxEars thinks it’ll be another 6. But I think it’s important to keep in mind...

Simple. You just regenerate the cochlea, the brain will then take care of rewiring itself. It's just like if you close your eyes and don't have light input, you'll see blue and red "noise." You restore vision input and the noise goes away. All that needs to be done is regenerating the cochlear...

The difference is synapses are more vulnerable and take the brunt of the damage. @OptimusPrimed is spot on, that is the primary underlying cause for tinnitus and hyperacusis. I fully believe that regenerating the cochlear synapses will be the most effective way possible to reverse tinnitus...

OTO-413 doesn't work by repairing hair cells. It works by regenerating cochlear synapses.

Looks like we're getting the news from everything, Pipeline Therapeutics, Otonomy, and Frequency Therapeutics in mid 2022.

Yes please do. Pipeline Therapeutics' drug and OTO-413 are our best two shots right now.

That's not right, no. Tinnitus is usually from damage to hearing, so having a drug that can regenerate the damage would treat the underlying cause of tinnitus AND would also improve hearing perception and clarity. It would also address such issues as hyperacusis that again are caused by the...

Yes but very rare, most of the people on this forum have tinnitus from loud sound exposure, which is most treatable by regenerative therapies such as Pipeline Therapeutics' drugs or OTO-413 that regenerate synapses. It probably would resolve tinnitus caused by ototoxic medication as well...

I disagree, we already know the overwhelming majority of cases of hyperacusis and tinnitus are caused by external insults especially acoustic trauma. We also know that synapses are most vulnerable not the hair cells themselves. It’s most certainly NOT “Whac-A-Mole” to the contrary it’s common...

It doesn't matter what the target audience is. Reversing tinnitus would be an incidental effect to the main purpose of regenerating synapses to reverse hidden hearing loss. You fix tinnitus by fixing the source of it, even if that's not the main purpose. So here, the most promising solution for...

It'd be nice if someone was able to get ahold of a Pipeline rep or employee to find out when we're getting any kind of results from the trial. Also to confirm again what someone said above, yes in humans according to Professor Liebermann; "the (spiral ganglion) cell bodies and central axons...

So is the consensus that the synapses remain viable for regeneration for decades in humans so we'll be able to benefit from PIPE-505 or OTO-413 even if they take years to go on the market?

"The repurposing of bisphosphonates shows promise in animal models for treating hidden hearing loss. At the present time, these drugs are not fit for hearing treatment because they have not yet been validated in human studies. For the purposes of treating metabolic bone disease—osteoporosis...

If I recall, during testing on mice, they were able to quite effectively regenerate the mice' cochlear hair cells with FX-322. So we know at least the drug regenerates cochlear hair cells. Perhaps yes it is a delivery problem. FREQ has a lot of trials going on right now. We should get more...

I don't see how Neuralink can be of benefit if it doesn't have any capacity of regenerating the cochlea. Neither cochear synapses nor hair cells. So it would do nothing for auditory input and hearing perception quality.

That's probably because these people had extremely mild damage to their cochlea such that tinnitus only appeared after prolonged periods of silence, that wouldn't be perceptible otherwise in day to day life. Someone who let's say has taken very good care of themselves, never forgot to wear...

See this is were I somewhat differ. I think we've all waited long enough and we want a regenerative therapy that will restore clarity perception, and hearing, and as an incidental effect of that, eliminate tinnitus. Frankly, I think we may enjoy the benefits of completely regenerating our...

Yes of course. Assuming you have for example noise-induced hearing loss then regenerating the damaged synapses and/or hair cells would reverse the tinnitus as well. Although as @Zugzug pointed out tinnitus can also arise (rarely) as a central only issue in those situations it may not help. But...

Because the regenerative treatments treat the underlying source of tinnitus which is most commonly damage to cochlear synapses, and sometimes from damage to hair cells or a combination of both. See:

But OTO-313 doesn't do anything to restore hearing. It's like treating the symptoms but not the underlying problem. Even if it did get rid of tinnitus (which would be great), it wouldn't restore hearing clarity and address hidden hearing loss. OTO-413 and Pipeline Therapeutics' drugs appear much...

Exactly, OTO-313 is useless for tinnitus because it is not a regenerative drug. Otonomy's only promising drug is OTO-413 because that actually was made for the purpose of restoring synapses, which would in turn improve tinnitus. Otonomy's got it wrong in how they are separating tinnitus and...

According to the latest research it is not so much the destruction of sound receptor hair cells, rather it is damage to cochlear synapses (which in turns causes progressive auditory nerve degeneration) that is the most significant cause of both tinnitus and loss of sound clarity perception...