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I don't know about announcements, but just considering it logically - yes, the same drug may work, but they'd need a whole new method of delivery. The vestibular system is even less accessible than the cochlea; getting the drug in there would need some research and possibly invasive surgery from...

Very interesting, can you provide any links?

There's a great discussion thread on Hacker News about hearing loss, started by a guy who suffered serious acoustic trauma from dropping a toilet cistern lid. Aside from the original article, the comments is a gold mine. https://news.ycombinator.com/item?id=16723099 In the thread: Some...

I was also in 72 hours after onset (ENTs are quite accessible in this country) but I only got 30mg of Prednisone and some really bad advice. I try to tell myself that the outcome would probably be the same regardless of what treatment I got. Still, it's frustrating. I actually wanted the MRI...

My ENT told me: There's no point injecting steroids in the ear since you can only inject into the middle ear, not the cochlea where the damage is. Reality: The drug passes from the middle to inner ear through a membrane called the round window. He later gave me the injection, but only after I...

That doesn't actually double your protection. It adds about 5dB of protection vs wearing just one method. For low-frequency sounds, it's less.

When people have hearing loss and tinnitus from otosclerosis (fused ear bones) or ear wax buildup, tinnitus often goes away when the cause of the hearing loss is cured. I read somewhere that in roughly 50% of otoscleroris cases with tinnitus, curing the otosclerosis improved hearing and fixed...

Why doesn't any of this stuff get tested on primates? If it works on a chimp (or even a monkey) it seems very likely it'd work on a human. Oh well. I guess it will get tested on primates - humans - during Frequency's stage 2 trial later this year.

I actually have no issue with hyperacusis, since a possibly psychosomatic and in any case mild version that ended within 2 weeks after tinnitus onset. In fact very loud sounds don't bother me at all at the moment they're happening. That's why I'm prioritizing protection. I'm watching to see if H...

Thanks for the discussion everyone. It was a loud, rainy windy day in the city. Traffic noise splashing by was loud but I think what really got me might have actually been the wind blasting past my head. Strong wind at certain angles makes a really loud noise in the ear; I didn't really...

There is a chance you could get in the phase 2 or phase 3 trials. Phase 3 trials especially, as I understand, tend to be quite large. It'd be great if someone from the forum could get involved.

I had intra-tympanic injection, it doesn't hurt in the slightest.As far as I could tell there is no feeling in the eardrum itself; it's like cutting nails or hair. There's advanced ways of making the hole now using lasers, too, apparently. It heals faster. Intratympanic injection is fine. And...

I really appreciate you coming back to write these updates. Thank you.

My tinnitus seems to spike even just from walking down the street in the city for 15 minutes. It generally seems to take a day or two to reduce to normal. Is is normal for tinnitus to spike this easily? Do I need to wear earplugs all the time even when just walking outside? It's been four...

It reminds me of vision in children. Sometimes a whole school system can end up thinking a child is mentally slow, and then it turns out that he just had bad eyesight. He couldn't read the blackboard, but he had no reference point to realize something wasn't right about his eyes. This is why...

It wouldn't be a great idea to buy stock in Frequency. Not because it's a bad company, but because you're already somewhat invested in the outcome and it's always better to diversify. It'd suck to lose hope for this treatment AND your money at the same time. Spread your bets.

This may be of interest to you (or maybe not), since you've done the supplement round but didn't mention vitamin D. https://www.youtube.com/watch?v=g3VnfsnH718

I got mine in late November 2017 and it's just reduced quite a bit in the last two weeks. You've got lots of time to make progress. Things to do: 1. Vitamin D, 5,000 IU per day. 2. Magnesium, anything except magnesium oxide, 350mg per day. 3. De-stress. Tinnitus is neurological, which means...

I'm also curious how diet factors in, since you mentioned sugar. What effect does sugar have? How do you know it had that effect? I'm trying to optimize my diet, which is why I ask. Thanks in advance!

Thanks for writing this. Please keep us updated on progress in the months to come!

Be careful with running. The impact motions travel up your body and may be able to harm to your ear if it's already been damaged (like all of ours have). See if you can find an elliptical machine or something! And I say this as someone who loves to run outside. That said, I have up that hobby...

These numbers are per-ear, by the way. You have double that if you count both ears. Still, it's a remarkably small number of cells!

Thanks! Yeah, that's the feature I'd want, though what'd make sense to me is to get it as a small headphone amplifier that just rolls off the volume at a high dB. E.g. I'd still want to be able to hear voices clearly, but if for some reason a loud sound came through it'd just drop that to a...

I have about 20dB loss around 2000-3500Hz in left ear only. But my tinnitus is unilateral and about 12,000Hz. Though sometimes it sound like it's more left-sided. I have a separate tone at 3000Hz but it's super quiet and I rarely even hear it. Even the slightest sound masks it so I can only...

To me a primary issue with headphones and earphones is that they always go wrong sooner or later and blast noise into your ears. It's just something that will happen - a bad connection, bad software, feedback... there are many causes. Even if it only happens once in 1000 times, that means it'll...

Jiri, could you edit your post to link that video with a pre-warning to tell people to set their PC volume to minimum first? Because you could give people the same problems you got.

This can just be part of the natural healing process. Lots of people have tinnitus go away up to 6 months after onset; some even up to 2 years or more after. Don't focus too hard on the details of "what you did to make it happen". Probably you didn't do anything. Stress will just make it...

I think I could make a tinnitus-like noise using jaw movement before I got tinnitus, though. So yes, I can, by pushing my jaw a special way, change the tinnitus noise. But, I'm pretty sure I'm just momentarily adding another noise on top of the permanent noise.

Is there anyone whose tinnitus started at a time when they were not already under intense mental stress?

Thanks for the info. How much did you take for how long? What's your body weight (just to compare dosage)? I took 2 weeks of 60mg/day. I'm ~90kg. It didn't seem to do much for me.

I don't really know what caused mine. It seems like noise, but the place I was in just wasn't that loud. I was on levofloxacin for 2 weeks before I got T though, so I think that may have put my ears in a vulnerable state. Anyway, I went to a bar. I had my earplugs in my pocket. But I walked...

I think phase 1 did not end early. They "reached all endpoints", which means they know they can measure what they set out to measure (in this case, whether the drug is dangerous). I'm pretty sure this really means, "we weren't forced to stop testing before the last patient." So there wasn't...

What are the top time-sensitive treatments to consider for tinnitus? When I first arrived here the information was hard to dig out. It requires looking through many, many threads, and evaluating each one. This took a lot of time, which slowed me down and made my treatment worse, since I needed...

I feel like this happened to me. I haven't abused my ears exceptionally or anything. I'm in my early 30's and probably went to clubs 20 times in my whole life - and just twice in the last five years. But I got tinnitus from a two-hour night at a bar that wasn't even that loud. We were having a...