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I had a microwick installed after reading this and replicated Renka's protocol with daily intratympanic Dexamethasone (10mg/mL solution) for 30 days. I was very optimistic but unfortunately no change in my tinnitus. The removal of the wick and tube actually worsened my hearing and tinnitus but...

Yeah if local Lidocaine has an effect, it is definitely going to be temporary. I had post-auricular Lidocaine injections done (injected directly behind the ear) but experienced no change in the tinnitus.

Intravenous Lidocaine (dripped in through an IV, rather than locally injected) silences tinnitus for some people... not sure exactly how/why, though from what I've read it does cross the blood brain barrier so it is probably floating around in your brain as well as your ear. You're awake during...

I just stumbled on this thread regarding Pramipexole, trying to convince my doctor to prescribe it for a trial - but I wanted to corroborate your experience regarding stellate ganglion blocks. I also had it done this year at a pain clinic for tinnitus. I showed the doctor the same papers you...

Two months now.

Godspeed. Agree the NAC could help mitigate damage if you were to try it again, especially for a longer period. I take 1.2g per day and have noticed that tinnitus spikes from unexpected loud noise exposures last far less longer now than they used to (1-2 days, rather than a week), presumably...

Hi Renka - I am replicating the same microwick protocol you did a few years ago based on your posts. Just had the microwick put in a couple days ago. What concentration of dexamethasone solution did you use? Was it either 24mg/mL or 10mg/mL dexamethasone sodium phosphate solution? Or was it a...

Actually got it done through a friend of a friend in Mexico who is not a stem cell doctor - but they sourced the stem cells from www.cryovidastemcells.com and had them shipped in overnight. This lab seems to supply MSCs to many doctors and clinics all around Mexico (e.g., see this article...

FYI, I have gone through the same process with StemCells21 and been presented with the same options. Prices are marginally negotiable - option 1 can be negotiated down to at least $32.3k (15% off). Good luck, keep us posted. Just got back from an UC-MSC infusion in Mexico myself (IV only) for...

Spot on. My understanding is that SSRIs are indeed not ototoxic but can trigger chronic tinnitus through the mechanism described in this post. There is a wealth of research now evidencing this mechanism. Excess serotonin in the dorsal cochlear nucleus causes the fusiform cells that are...

@ChiggyT, have you seen this post re: Nortriptyline? Don’t want to beat a dead horse but I strongly suspect Nortriptyline is behind your tinnitus, especially given that it is somatic. Excess serotonin in the DCN causes somatic and auditory nerve input signals to get mixed up, causing tinnitus.

It was with a normal acupuncturist (American lady, trained in Chinese acupuncture) - but we did the exact same points around the ear in an attempt to replicate the Chinese case study.

I had a unilateral SGB done (on my worse side) on the basis of that paper from China, with 5 days of acupuncture after it. The SGB was ultrasound guided with a neck X-ray also taken prior to the procedure. Took ~10 minutes of them inserting a needle into my neck to find the right place. Felt...

I took Amitriptyline (another TCA) for 5 days before it triggered my tinnitus back in 2015. I had some headaches and whiplash injury prior to that, but it was the medication that triggered it. I know Amitriptyline is not Nortriptyline but it is very similar within the class of tricyclic...

Don't believe the GP. Most are unfamiliar with tinnitus as a side effect of tricyclic antidepressants (mine refused to believe it as well). While the underlying cause may be the nerve issues or some other muscle/structural issue, the trigger was almost certainly Nortriptyline. I would wean off...

Interesting to note that some people have seen benefit to their tinnitus from taking NAC by itself... though I've tried it at very high doses with no effect. Curious if it will affect your tinnitus along with Flupirtine. Looking forward to your updates @StoneInFocus, praying for success.

Same boat as you (somatic tinnitus, no high frequency hearing loss). Pretty sure mine was triggered by 5 days of taking 10 mg Amitriptyline, which the doctor assured had no side effects. I stopped the medication as soon as tinnitus started but it never went away. Very frustrating that this isn't...

Fair warning - my experience is that Adam Fields is a quack who made my situation way, way worse with his "endo-nasal" cranial adjusting. He actually CAUSED severe Eustachian tube dysfunction and TMJ problems for me that I never had before he stuck those latex balloons down my nose and crushed...

Same experience here. I was initially disappointed to not be able to participate but actually now thankful they did this kind of screening. Not worth risking pushing someone over the edge if their tinnitus is already catastrophic and the study accidentally makes it worse. I know someone who...

Ela - I would refer you to this discussion re: Perampanel. Haven't had any experience with it myself. It is also an anti-convulsant but of a different class than the ones we're discussing here (Flupirtine and Trobalt - both K channel openers).

I totally feel you brother. Am definitely planning to try it but unfortunately won't be able until late summer / early fall when I have a chance to travel and procure some abroad. If you are able to try it and report back before then, please keep us posted. I will do the same. I think the...

I didn't unfortunately. Agree with you, would rather take the drug for life if it works, even if it means shaving some years off. Been following Xenon Pharmaceuticals' XEN-1101 as well - will probably take another 2 years to get to FDA approval, from what I can tell. Promising but also...

It can damage your liver, but as an uncommon side effect, not as a rule. Many chronic users of Flupirtine suffer no hepatotoxicity, while some short-term users suffer serious injury (even acute liver failure) from a few weeks of use. Luck of the draw (or maybe more like Russian roulette). A...

Great question. I used to be under the same impression that auditory system damage is a prerequisite, and this still seems to be a common view among doctors. However, there are a couple papers that have changed my mind recently, as well as anecdotal evidence / experiences that point to the...

Basically a real time MRI that lets them see which parts of the brain are more/less active over a period of time. So if your tinnitus fades away as the Lidocaine takes effect, they can see where in the brain the activity levels are changing. Wikipedia: Functional Magnetic Resonance Imaging

No real effect for me. But a good diagnostic tool. If it silences your tinnitus while you’re on it (which it has done for others), you know it’s likely of acoustic trauma / cochlear origin. If it doesn’t do anything for your tinnitus, and you don’t have measurable hearing loss, you know the...

Hey - the electrical stimulation trial was at UC Irvine. I had to fly out there. Same with the Nortriptyline / Topiramate trial. But I've done two trials in the northeast (IV Ketamine - at Columbia in NYC; IV Lidocaine - at Mass Eye and Ear in Boston). These were investigational trials, for...

Corroborates my experience with intravenous Ketamine. No impact on the tinnitus during the infusion, followed by a spike in tinnitus afterwards that resolved to pre-infusion baseline after a few days. For those asking about where to get it done / how to pay for it, sign up for the clinical...

They are still working on it - trying to develop a device that can be used on ongoing basis. The results from the trans-tympanic stimulation are just transitory as others have said. Once the current stops, the tinnitus comes back. Like Gb3 noted it was a trial. Not an approved therapy. Free to...

I participated in the acoustic and electrical stimulation study a couple years ago - interesting experience, would recommend to anyone who has time and resources to participate, regardless of whether it helps with the tinnitus or not. I only did electrical stimulation using external electrodes...

DO NOT go to these quacks for "treatment." The nasal specific / cranial adjusting technique they describe is not safe -- I had it done from another chiropractor who similarly claimed to be able to "treat" tinnitus and it dislocated my jaw and caused Eustachian tube dysfunction ever since. Stay...

As another aside, unrelated to this thread, I think I should've added one more element to the original poll: neuroticism. Unclear exactly which is the cause vs. effect -- i.e. whether tinnitus more often affects people who are more Type A / neurotic, or if tinnitus itself tends to make...

Gotcha. Know for SSI claims they ask for evidence of hearing loss, which of course doesn’t show up in the slightest on audiograms for many of us, myself included. But private insurance is different. Good luck.

Did you file for STD, and if so what kind of evidence did they ask for? This has been an important open question for a long time, i.e. whether it is possible or not to make a successful claim for tinnitus.

Thanks for posting your experience with this. Great to know, and I only wish I would’ve heard it a bit sooner! Just got off a 10-day course of prednisone after a big spike (literally after watching Tenet) that unfortunately didn’t do much for the spike (my tinnitus now permanently higher) but...

Makes sense, thanks for posting. As an aside — I wish deep brain stimulation was an option for us with a little bit more risk tolerance. Seems to help in early stages of both those diseases, and has been shown in a few studies to quiet T. In any case, if we live to see Elon Musk’s Neuralink...

Thanks for this post, interesting theory and helpful to compare experiences. FWIW, my tinnitus was mostly likely caused by stress and chronic sleep deprivation leading to excess glutamate, and I participated in this ketamine trial at Columbia and it had no impact. Of course the purpose of the...

Nearly 12 hours a night. Falling asleep is sometimes tough without maskers/white noise machines, but staying asleep has not been a problem. Interesting though that before the tinnitus started I could get by with 6 hours a night on weeknights and a few extra on the weekend. 8 hours was enough to...

TAKE PREDNISONE Another reply already mentioned it but it cannot be emphasized enough. Go get a high-dose course of prednisone from you GP as soon as possible. Best case scenario, it makes the tinnitus go away forever. Prednisone is only able to do that if you nip it in the bud in the first...

I have had tinnitus for 5 years now and immediately when it started, I noticed a significant impact on my working memory, cognitive speed and acuity, and even social ability (as it related to word recall and quick thinking in conversations). For 2-3 years, this unfortunate impact was stable...

FYI for any interested - I went and paid up for the 1 week initial consultation and treatment a few months ago. Spiked my T, and it has remained marginally worse since. rTMS in general I realize now is too blunt of a tool to have any positive effects on tinnitus, at least at this stage. They...

For the record, I have tried lidocaine injections behind the ear with no effect on the tinnitus. I think it's just intravenous lidocaine that suppresses the tinnitus, not localized injection unfortunately.

@billie48 that may be the most comprehensive list of contributing factors / potential causes I've ever seen. Thanks for compiling. @Cmp216 go get a prescription for prednisone IMMEDIATELY. Who knows what the real cause is, but for some people, there is a 5-10 day window in which the tinnitus...

Hi Mr. Science, Hope you’re well. I have had severe tinnitus for a while that has just progressively gotten worse and want to pursue some experimental treatment options abroad. Could you please help me with the names of the clinics you went to? Which one would you recommend for a first time...

Sorry to necropost... but seems like this is the official Brivaracetam thread. Haven't seen any actual reports of people trying it so though I would give my experience. Just got an Rx last week at 50mg 2x a day. Hasn't had any effect on my tinnitus, and just made me kind of...

Had a very similar experience with trying amitriptyline again a couple months ago. First day felt good, less intense, then second day was worse than baseline (but I also slept very little the night before, which likely had an impact). (Write-up here...

Appreciate the response, Chris, and agreed - after reading a bit more about the side effects, seems like Trobalt is indeed not worth the risk of developing something worse than T (can't even begin to imagine what that is like... respect to you, Patrick, and appreciate the warning). To others...

Is there a particular pharmacy there that still has it in stock? Others have also mentioned finding it in Mexico and Dominican Republic, although that was in 2018.... if any of you are still around and remember which pharmacy you found some, that would be very helpful. Am trying to find some...

Hi Tony, Appreciate your posts on the site re Retigabine. I was wondering if you could provide more color on where it is available? I have so far been unable to get any to try here in the US, and am looking to plan a trip to get some. Is there a particular pharmacy in Malaga you know that has...

Fair warning to all those reading this thread. Five days into a 10 mg Amitriptyline script for sleep, first time ever taking it, my tinnitus started. High-pitched stereo squeal. My doctor said it would go away if I stopped taking it, so I did, but have had tinnitus ever since (4.3 years now)...

Count your lucky stars. I used to be convinced (admittedly by fox news propaganda) that our healthcare was the best in the world.. that people in socialized countries envied our system. Had never needed a doctor before my T started and really believed everything was hunky dory. Only in the...

Hi all, I recently stumbled across some articles discussing "MeRT" treatment, which basically seems to be a modified version of rTMS, as being effective for veterans with PTSD and other anxiety disorders. Given what I know about tinnitus, particularly the type I have (high pitched ~16000 Hz...

Hey man, just wanted to say you're a fucking hero for writing the stuff you do on this forum. Thanks, and please keep it up. My situation is sadly similar to yours, but I don't have the balls to sit down and write about it because focusing on it just makes the frustration/despair worse. You're...

Hey! I read your post on success with Prednisone, and was wondering if it ended up having a lasting effect, and/or if the tinnitus came back? Am thinking of asking my doc for a high dose 10-day course of prednisone and would love to know more about your experience (as little or as much as you're...